Biomaterials, Год журнала: 2024, Номер 314, С. 122853 - 122853
Опубликована: Сен. 27, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 113 - 140
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139532 - 139532
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
Molecular Aspects of Medicine, Год журнала: 2025, Номер 102, С. 101350 - 101350
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117372 - 117372
Опубликована: Авг. 28, 2024
Polymeric nanoparticles have emerged as promising contenders for addressing the intricate challenges encountered in brain tumor therapy due to their distinctive attributes, including adjustable size, biocompatibility, and controlled drug release kinetics. This review comprehensively delves into latest developments synthesizing, characterizing, applying polymeric explicitly tailored therapy. Various synthesis methodologies, such emulsion polymerization, nanoprecipitation, template-assisted fabrication, are scrutinized within context of targeting, elucidating advantages limitations concerning traversing blood-brain barrier. Furthermore, strategies pertaining surface modification functionalization expounded upon augment stability, targeting prowess amidst milieu microenvironment. Characterization techniques encompassing dynamic light scattering, transmission electron microscopy, spectroscopic methods evaluate physicochemical attributes engineered Moreover, a comprehensive exploration manifold applications delivery, gene therapy, imaging, combination therapies tumours is undertaken. Special emphasis placed on encapsulation diverse therapeutics nanoparticles, thereby shielding them from degradation enabling precise brain. Additionally, recent advancements stimuli-responsive multifunctional probed potential personalized medicine theranostics tumours. In essence, this furnishes an all-encompassing overview strides made tailoring illuminating synthesis, characterization, multifaceted application.
Язык: Английский
Процитировано
4
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107659 - 107659
Опубликована: Фев. 1, 2025
Ribonucleic acid (RNA) aptamers are single-stranded RNAs that bind to target proteins or other molecules with high specificity and affinity, modulating biological functions through distinct mechanisms. These can act n as antagonists block pathological interactions, agonists activate signaling pathways, delivery vehicles for therapeutic cargos such siRNAs miRNAs. The advances in RNA nanotechnology further enhances the versatility of aptamers, offering scalable platforms engineering. In this review, we have summarized recent developments aptamer-mediated provide an overview its potential treating cardiovascular respiratory disorders, including atherosclerosis, acute coronary syndromes, heart failure, lung cancer, pulmonary hypertension, asthma, chronic obstructive disease (COPD), injury, viral infections, fibrosis. By integrating aptamer technologies innovative systems, hold revolutionize treatment landscape cardiopulmonary diseases.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 291 - 318
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Drugs, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
Язык: Английский
Процитировано
0
Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Advances in genomic technologies have significantly enhanced our understanding of both monogenic and polygenic etiologies cardiovascular disease. In this review, we explore how the utilization information is bringing personalized medicine approaches to forefront disease management. We discuss data can resolve diagnostic uncertainty, support cascade screening, inform treatment strategies. The role that genome-wide association studies had identifying thousands risk variants for diseases, these insights, harnessed through development scores, could advance prediction beyond traditional clinical algorithms. detail pharmacogenomics leverage genotype guide drug selection mitigate adverse events. Finally, present paradigm-shifting approach gene therapy, which holds promise being a curative intervention conditions.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 10, 2024
Protein drugs are of great importance in maintaining the normal functioning living organisms. Indeed, they have been instrumental combating tumors and genetic diseases for decades. Among these pharmaceutical agents, those that target intracellular components necessitate use therapeutic proteins to exert their effects within targeted cells. However, protein is limited by short half-life potential adverse physiological environment. The advent nanoparticles offers a promising avenue prolonging drugs. This achieved encapsulating proteins, thereby safeguarding biological activity ensuring precise delivery into nanomaterial-based drug system mitigates rapid hydrolysis unwarranted diffusion minimizing side circumventing limitations inherent traditional techniques like electroporation. review examines established systems, including based on polymers, liposomes, nanoparticles. We delve operational principles transport mechanisms nanocarriers, discussing various considerations essential designing cutting-edge platforms. Additionally, we investigate innovative designs applications cytosolic systems medical research clinical practice, particularly areas tumor treatment, gene editing fluorescence imaging. sheds light current restrictions anticipates future avenues, aiming foster continued advancement this field.
Язык: Английский
Процитировано
1