Role of PEGylated lipid in lipid nanoparticle formulation for in vitro and in vivo delivery of mRNA vaccines
Li Zhang,
Brandon Yi Loong Seow,
K Ba
и другие.
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 108 - 124
Опубликована: Фев. 5, 2025
Язык: Английский
Advances in Lipid Nanoparticle‐Based Disease Treatment
ChemMedChem,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Abstract
Lipid
nanoparticles
(LNPs)
have
emerged
as
a
transformative
platform
for
the
targeted
delivery
of
therapeutic
agents,
revolutionizing
treatment
paradigms
across
spectrum
diseases.
Since
inception
liposomes
in
1960s,
lipid‐based
nanotechnology
has
evolved
to
address
limitations
such
poor
bioavailability,
off‐target
effects,
and
instability,
thereby
enhancing
efficacy
safety
drug
administration.
This
review
highlights
latest
advancements
LNPs
technology,
focusing
on
their
application
cancer
therapy,
gene
infectious
disease
management,
glaucoma,
other
clinical
areas.
Recent
studies
underscore
potential
deliver
messenger
RNA
(mRNA)
small
interfering
(siRNA)
precise
genetic
intervention,
exemplified
by
breakthroughs
interference
CRISPR‐Cas9
genome
editing.
Additionally,
been
successfully
employed
ameliorate
conditions,
demonstrating
versatility
addressing
both
acute
chronic
disorders.
However,
challenges
persist
concerning
large‐scale
manufacturing,
long‐term
stability,
comprehensive
evaluations.
Future
research
must
focus
optimizing
formulations,
exploring
synergistic
combinations
with
existing
therapies,
expanding
scope
treatable
The
integration
into
personalized
medicine
exploration
applications
diseases
represent
promising
avenues
further
investigation.
are
poised
play
an
increasingly
central
role
development
next‐generation
therapeutics.
Язык: Английский
Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100283 - 100283
Опубликована: Сен. 10, 2024
Язык: Английский
Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown, С. 113641 - 113641
Опубликована: Март 1, 2025
Язык: Английский
The Fomivirsen, Patisiran, and Givosiran Odyssey: How the Success Stories May Pave the Way for Future Clinical Translation of Nucleic Acid Drugs
BioDrugs,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 5, 2025
Язык: Английский
Engineering innate immune cells for cancer immunotherapy
Nature Biotechnology,
Год журнала:
2025,
Номер
43(4), С. 516 - 533
Опубликована: Апрель 1, 2025
Язык: Английский
New insights into diabetes-induced cardiac pathology
Journal of Molecular and Cellular Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
In vivo gene editing and in situ generation of chimeric antigen receptor cells for next-generation cancer immunotherapy
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Ноя. 13, 2024
Chimeric
antigen
receptor
(CAR)
cell
therapy
has
achieved
groundbreaking
success
in
treating
hematological
malignancies.
However,
its
application
to
solid
tumors
remains
challenging
due
complex
manufacturing
processes,
limited
vivo
persistence,
and
transient
therapeutic
effects.
In
CAR-immune
cells
induced
by
gene
delivery
systems
loaded
with
CAR
genes
gene-editing
tools
have
shown
efficiency
for
anti-tumor
immunotherapy.
situ
programming
of
autologous
immune
avoids
the
safety
concerns
allogeneic
cells,
manufacture
could
be
standardized.
Therefore,
editing
generation
might
potentially
overcome
abovementioned
limitations
current
therapy.
This
review
mainly
focuses
on
structures,
tools,
techniques
applied
immunotherapy
help
design
develop
The
recent
applications
both
hematologic
malignancies
are
investigated.
To
sum
up,
holds
promise
offering
a
practical,
cost-effective,
efficient,
safe,
widely
applicable
approach
next-generation
Язык: Английский
The Impact of COVID-19 on RNA Therapeutics: A Surge in Lipid Nanoparticles and Alternative Delivery Systems
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1366 - 1366
Опубликована: Окт. 25, 2024
The
COVID-19
pandemic
has
significantly
accelerated
progress
in
RNA-based
therapeutics,
particularly
through
the
successful
development
and
global
rollout
of
mRNA
vaccines.
This
review
delves
into
transformative
impact
on
RNA
with
a
strong
focus
lipid
nanoparticles
(LNPs)
as
pivotal
delivery
platform.
LNPs
have
proven
to
be
critical
enhancing
stability,
bioavailability,
targeted
mRNA,
facilitating
unprecedented
success
vaccines
like
those
developed
by
Pfizer-BioNTech
Moderna.
Beyond
vaccines,
LNP
technology
is
being
explored
for
broader
therapeutic
applications,
including
treatments
cancer,
rare
genetic
disorders,
infectious
diseases.
also
discusses
emerging
systems,
such
polymeric
viral
vectors,
which
offer
alternative
strategies
overcome
existing
challenges
related
immune
responses,
tissue-specific
targeting.
Additionally,
we
examine
pandemic's
influence
regulatory
processes,
fast-tracked
approvals
therapies,
surge
research
funding
that
spurred
further
innovation
field.
Public
acceptance
grown,
laying
groundwork
future
developments
personalized
medicine.
By
providing
an
in-depth
analysis
these
advancements,
this
highlights
long-term
evolution
therapeutics
precision
drug
technologies.
Язык: Английский
Nano Delivery System for Atherosclerosis
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
16(1), С. 2 - 2
Опубликована: Дек. 24, 2024
Atherosclerosis,
a
pathological
process
propelled
by
inflammatory
mediators
and
lipids,
is
principal
contributor
to
cardiovascular
disease
incidents.
Currently,
drug
therapy,
the
primary
therapeutic
strategy
for
atherosclerosis,
faces
challenges
such
as
poor
stability
significant
side
effects.
The
advent
of
nanomaterials
has
garnered
considerable
attention
from
scientific
researchers.
Nanoparticles,
liposomes
polymeric
nanoparticles,
have
been
developed
delivery
in
atherosclerosis
treatment.
This
review
will
focus
on
how
nanoparticles
effectively
improve
safety
efficacy,
well
continuous
development
optimization
same
material
further
explore
current
future
opportunities
this
field.
Язык: Английский