Are Nanostructured Lipid Carriers (NLC) better than Solid Lipid Nanoparticles (SLN) for delivering abiraterone acetate through the gastrointestinal tract?

International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124869 - 124869

Опубликована: Окт. 1, 2024

Язык: Английский

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126541 - 126541

Опубликована: Ноя. 1, 2024

Язык: Английский

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A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma

npj Vaccines, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 3, 2025

Язык: Английский

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Tannic acid-modified FK506-loaded nanoparticles targeting lymph nodes for acute heart transplant rejection treatment

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125247 - 125247

Опубликована: Янв. 1, 2025

Язык: Английский

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Thermo‐pH‐Sensitive Polypeptides Boost Protein Drug's Tumor Permeation and Pharmacology

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Proteins are typically subject to poor stability, short half-life, and cell tissue permeability, which restrict their wide applications as drugs for disease treatment. Current protein modification techniques mostly focus on improving the stability half-life of proteins, but hardly solve permeability. To address this issue, study innovatively designs thermo-pH-sensitive elastin-like polypeptides modify named ELP(HX)n in histidine (H) any amino acid except proline (X) guest acids n is total number acids. H can be protonated under acidic conditions. prove concept, an important drug L-asparaginase (ASP) genetically fused ELP(HV)60 generate ASP-ELP(HV)60. Compared with ASP PEGylated ASP, ASP-ELP(HV)60 exhibits not only elevated extended also enhanced tumor penetration, resulting improved antitumor efficacy. These findings demonstrate that fusion a novel general method overcome intrinsic limitations proteins therapeutics, rendering it feasible design intelligent especially efficient therapy.

Язык: Английский

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Lipid nanoparticles as a strategy to enhance abiraterone acetate oral bioavailability: insights into intestinal uptake and pharmacokinetic profiles

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106947 - 106947

Опубликована: Апрель 1, 2025

Язык: Английский

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Navigating Neurotoxicity and Safety Assessment of Nanocarriers for Brain Delivery: Evaluation Models and Insights

Acta Biomaterialia, Год журнала: 2024, Номер 189, С. 25 - 56

Опубликована: Сен. 20, 2024

Язык: Английский

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Biocompatability chitosan /Aloe barbadensis miller loaded moxifloxacin composite film: A multifunctional bio-platform for the treatment of breast cancer

Journal of Molecular Structure, Год журнала: 2024, Номер 1315, С. 138618 - 138618

Опубликована: Май 14, 2024

Язык: Английский

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Fabrication of Luteolin Nanoemulsion by Box-Behnken Design to Enhance its Oral Absorption Via Lymphatic Transport

AAPS PharmSciTech, Год журнала: 2024, Номер 25(7)

Опубликована: Сен. 5, 2024

Язык: Английский

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Emerging Cationic Nanovaccines

Опубликована: Июнь 20, 2024

Nanovaccines are able to deliver antigen(s) and immunomodulator(s) directly antigen-presenting cells (APCs) of the lymphatic system. Positive charges improve their uptake by APCs often drive a Th-1 biased immune response so necessary against infectious diseases caused intracellular pathogens cancers. However, cationic compounds display dose-dependent toxicity that systematic evaluation cytotoxicity in culture is required. After rapid evolution nanovaccines SARS-Covid 2, mRNA vaccines gained much strength have been designed several diseases, relying on components for protection. Once established limiting concentration compound, perform well eliciting desired improved most cases. Other valuable approach found literature has construction biocompatible nanoparticles (NPs) carrying lipids, polymers or surfactants minimization component led absence toxicity. Against cancer, recent constructions situ after cancer cell disruption presence adjuvants systemic presentation multiple tumoral antigens yielding, many instances, prevention metastasis appearance conversion tumors non treatable immunotherapy into ones.

Язык: Английский

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