Lipid Nanoparticles as a Strategy to Enhance Abiraterone Acetate Oral Bioavailability: Insights into Intestinal Uptake and Pharmacokinetic Profiles DOI

Oksana Lemasson,

S. Briançon,

Valentine Daret

et al.

Published: Jan. 1, 2024

Language: Английский

Are Nanostructured Lipid Carriers (NLC) better than Solid Lipid Nanoparticles (SLN) for delivering abiraterone acetate through the gastrointestinal tract? DOI

Oksana Lemasson,

S. Briançon,

Vanessa Bourgeaux

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124869 - 124869

Published: Oct. 1, 2024

Language: Английский

Citations

4
Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing DOI
Shengyu Zhang, Muhammad Ali,

Farooq Nawaz

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541

Published: Nov. 1, 2024

Language: Английский

Citations

4
A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma DOI Creative Commons

Xingyang Zhao,

Feichao Xuan,

Zirong Li

et al.

npj Vaccines, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 3, 2025

Language: Английский

Citations

0
Tannic acid-modified FK506-loaded nanoparticles targeting lymph nodes for acute heart transplant rejection treatment DOI

Jiani Qiu,

Yishu Song,

Mengrong He

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125247 - 125247

Published: Jan. 1, 2025

Language: Английский

Citations

0
Thermo‐pH‐Sensitive Polypeptides Boost Protein Drug's Tumor Permeation and Pharmacology DOI Open Access

Like Gong,

Yuan Qi, Fan Zhang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Proteins are typically subject to poor stability, short half-life, and cell tissue permeability, which restrict their wide applications as drugs for disease treatment. Current protein modification techniques mostly focus on improving the stability half-life of proteins, but hardly solve permeability. To address this issue, study innovatively designs thermo-pH-sensitive elastin-like polypeptides modify named ELP(HX)n in histidine (H) any amino acid except proline (X) guest acids n is total number acids. H can be protonated under acidic conditions. prove concept, an important drug L-asparaginase (ASP) genetically fused ELP(HV)60 generate ASP-ELP(HV)60. Compared with ASP PEGylated ASP, ASP-ELP(HV)60 exhibits not only elevated extended also enhanced tumor penetration, resulting improved antitumor efficacy. These findings demonstrate that fusion a novel general method overcome intrinsic limitations proteins therapeutics, rendering it feasible design intelligent especially efficient therapy.

Language: Английский

Citations

0
Lipid nanoparticles as a strategy to enhance abiraterone acetate oral bioavailability: insights into intestinal uptake and pharmacokinetic profiles DOI

Oksana Lemasson,

S. Briançon,

Valentine Daret

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106947 - 106947

Published: April 1, 2025

Language: Английский

Citations

0
Navigating Neurotoxicity and Safety Assessment of Nanocarriers for Brain Delivery: Evaluation Models and Insights DOI Creative Commons
Maria Inês Teixeira, Carla M. Lopes, Maria Helena Amaral

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 189, P. 25 - 56

Published: Sept. 20, 2024

Language: Английский

Citations

3
Biocompatability chitosan /Aloe barbadensis miller loaded moxifloxacin composite film: A multifunctional bio-platform for the treatment of breast cancer DOI

Gowri Rengasamy,

Sundrarajan Mahalingam,

Thamayanthi Udaiyar

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1315, P. 138618 - 138618

Published: May 14, 2024

Language: Английский

Citations

2
Fabrication of Luteolin Nanoemulsion by Box-Behnken Design to Enhance its Oral Absorption Via Lymphatic Transport DOI
Liangxing Tu, Wang Ju, Yongbing Sun

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(7)

Published: Sept. 5, 2024

Language: Английский

Citations

2
Emerging Cationic Nanovaccines DOI Open Access
Ana Maria Carmona‐Ribeiro, Yunys Pérez-Betancourt

Published: June 20, 2024

Nanovaccines are able to deliver antigen(s) and immunomodulator(s) directly antigen-presenting cells (APCs) of the lymphatic system. Positive charges improve their uptake by APCs often drive a Th-1 biased immune response so necessary against infectious diseases caused intracellular pathogens cancers. However, cationic compounds display dose-dependent toxicity that systematic evaluation cytotoxicity in culture is required. After rapid evolution nanovaccines SARS-Covid 2, mRNA vaccines gained much strength have been designed several diseases, relying on components for protection. Once established limiting concentration compound, perform well eliciting desired improved most cases. Other valuable approach found literature has construction biocompatible nanoparticles (NPs) carrying lipids, polymers or surfactants minimization component led absence toxicity. Against cancer, recent constructions situ after cancer cell disruption presence adjuvants systemic presentation multiple tumoral antigens yielding, many instances, prevention metastasis appearance conversion tumors non treatable immunotherapy into ones.

Language: Английский

Citations

1