Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125289 - 125289

Опубликована: Янв. 1, 2025

Язык: Английский

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Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine

Toxics, Год журнала: 2025, Номер 13(3), С. 178 - 178

Опубликована: Фев. 28, 2025

Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.

Язык: Английский

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Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Protocells offer a versatile material for dissecting cellular processes and developing simplified biomimetic systems by combining biological components with synthetic ones. However, gap exists between the integrity complex functionality of native organelles such as nuclei, bottom‐up strategies reducing functions within environment. Here, this is bridged incorporating nuclei into polymeric giant unilamellar vesicles (pGUVs) using double‐emulsion microfluidics. It shown that retain their morphology nuclear envelope integrity, facilitating import co‐encapsulated peptide‐based multicompartment micelles (MCMs) via localization signals (NLS). Importantly, it demonstrated machinery remains functional inside protocells, enriching GUV interior import‐promoting factors, delivery efficiency NLS‐MCMs significantly increases. The findings reveal nucleated protocells preserve function extended periods, providing new platform studying in simplified, yet biologically relevant, This approach opens avenues creating advanced biohybrid materials, offering opportunities to investigate organelle behavior interactions greater detail. establish foundation high‐throughput applications biology contribute valuable insights sustaining engineered systems.

Язык: Английский

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Influences of chain length and conformation of guanidinylated linear synthetic polypeptides on nuclear delivery of siRNA with potential application in transcriptional gene silencing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142743 - 142743

Опубликована: Апрель 1, 2025

Язык: Английский

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The Journey and Modes of Action of Therapeutic Nanomaterials in Cells

Bioconjugate Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Over past decades, a wide range of nanomaterials have been synthesized and exploited to augment the efficacy biocompatibility disease theranostics nanomedicine. The unique physicochemical properties nanomaterials, such as high specific surface area, tunable size shape, versatile chemistry, enable controlled modulation nanomaterial-biosystem interactions and, consequently, more precise interventions, particularly at cellular level. selective nanomaterial-cell can be leveraged regulate internalization, intracellular trafficking localization, clearance enhance therapeutic minimize potential cytotoxicity. Herein, we provide an overview our recent understanding journey modes action in cells. Specifically, highlight various pathways trafficking, excretion these nanomaterials. different especially release delivery, photothermal photodynamic effects, immunomodulation, are also discussed. We conclude review by offering some perspectives on current challenges opportunities this field.

Язык: Английский

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The Potential of Nuclear Pore Complexes in Cancer Therapy

Molecules, Год журнала: 2024, Номер 29(20), С. 4832 - 4832

Опубликована: Окт. 12, 2024

Nuclear pore complexes (NPCs) play a critical role in regulating transport-dependent gene expression, influencing various stages of cancer development and progression. Dysregulation nucleocytoplasmic transport has profound implications, particularly the context cancer-associated protein mislocalization. This review provides specific information about relationship between nuclear complexes, key regulatory proteins, their impact on biology. Highlighting influence tumor-suppressor proteins as well potential gold nanoparticles intelligent nanosystems treatment, inhibiting cell invasion is examined. article concludes with clinical implications export inhibitors, XPO1, therapeutic target cancers, selective inhibitors compounds demonstrating efficacy both hematological solid malignancies. The aims to explore NPCs biology, focusing progression, mislocalization, targeted therapies such treatment. Despite significance number research studies, direct carcinogenesis remains incompletely understood.

Язык: Английский

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Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115460 - 115460

Опубликована: Окт. 1, 2024

Язык: Английский

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