Journal of Advance Research in Medical & Health Science (ISSN 2208-2425),
Год журнала:
2024,
Номер
10(2), С. 100 - 104
Опубликована: Фев. 10, 2024
Aging
is
a
risk
factor
for
various
chronic
diseases
such
as
diabetes,
dyslipidemia,
metabolic,
neurological,
and
cardiovascular
disease,
other
age-related
disorders.
Nicotinamide
mononucleotide
(NMN)
one
of
the
endogenous
intermediate
molecules
in
nicotinamide
adenine
dinucleotide
(NAD)
biosynthesis,
its
biological
function
known
to
be
related
an
increase
NAD
concentration.
levels
decline
are
critical
human
health
longevity.
The
material
methods
using
systematic
review
RCT,
with
participants
healthy
adults
aged
between
20-65
years
old,
agreed
take
NMN
supplementation
compared
Placebo.
inclusion
criteria
RCT
studies
regarding
administration
outcome
prevent
aging
primary
objective
measurement
blood
Trial
quality
was
assessed
JBI
checklist.
We
included
six
average
duration
intervention
10-12
weeks
dosage
250-900mg/day.
All
showed
that
can
significantly
improve
concentration
cause
only
mild
adverse
effects
during
trial.
In
conclusion,
has
significant
clinical
impact
preventing
adult
aging.
Nicotinamide
mononucleotide
(NMN),
a
key
NAD+
precursor,
exhibits
distinct
metabolic
characteristics
and
potential
health
benefits.
Recent
investigations
underscore
the
pivotal
role
of
gut
bacteria
specialized
uptake
mechanisms
in
NMN
metabolism.
While
human
trials
demonstrate
NMN's
safety
promising
outcomes,
challenges
persist.
Variability
results
is
likely
influenced
by
lifestyle,
conditions,
individual
genetic
microbiota
differences.
Understanding
how
these
factors
affect
metabolism
crucial
for
personalized
approaches
maximizing
potential.
Advances
delivery
systems
show
promise
enhancing
bioavailability,
but
further
understanding
optimal
levels
reliable
measures
effects
necessary.
This
comprehensive
approach
to
optimizing
impact
on
longevity.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 1, 2024
β-nicotinamide
mononucleotide
(NMN)
is
a
naturally
occurring
biologically
active
nucleotide
widely
present
in
organisms
and
an
inherent
substance
the
human
body.
As
critical
intermediate
synthesizing
coenzyme
I
(NAD+),
it
participates
multiple
biochemical
reactions
body
closely
related
to
immunity,
metabolism,
other
factors.
In
recent
years,
NMN
has
rapidly
developed
made
significant
progress
medicine,
food,
healthcare.
However,
there
currently
lack
of
comprehensive
reports
on
research
NMN,
as
well
exploration
analysis
current
achievements
NMN.
Therefore,
this
review
based
retrieving
relevant
from
databases
at
home
abroad,
with
retrieval
time
database
establishment
20
May
2024.
Subsequently,
literature
search,
reading,
key
information
extraction,
organization,
summarization
were
conducted
aim
providing
in-depth
characteristics,
metabolic
pathways,
pharmacological
effects,
clinical
trials,
wide
applications
drug
development
food
applications.
Furthermore,
offers
personal
insights
into
NMN’s
potential
future
developments
advancements
state
existing
challenges
comprehensively.
Ultimately,
aims
provide
guidance
serve
reference
for
application,
innovation,
progression
research.
Journal of Advance Research in Medical & Health Science (ISSN 2208-2425),
Год журнала:
2024,
Номер
10(2), С. 100 - 104
Опубликована: Фев. 10, 2024
Aging
is
a
risk
factor
for
various
chronic
diseases
such
as
diabetes,
dyslipidemia,
metabolic,
neurological,
and
cardiovascular
disease,
other
age-related
disorders.
Nicotinamide
mononucleotide
(NMN)
one
of
the
endogenous
intermediate
molecules
in
nicotinamide
adenine
dinucleotide
(NAD)
biosynthesis,
its
biological
function
known
to
be
related
an
increase
NAD
concentration.
levels
decline
are
critical
human
health
longevity.
The
material
methods
using
systematic
review
RCT,
with
participants
healthy
adults
aged
between
20-65
years
old,
agreed
take
NMN
supplementation
compared
Placebo.
inclusion
criteria
RCT
studies
regarding
administration
outcome
prevent
aging
primary
objective
measurement
blood
Trial
quality
was
assessed
JBI
checklist.
We
included
six
average
duration
intervention
10-12
weeks
dosage
250-900mg/day.
All
showed
that
can
significantly
improve
concentration
cause
only
mild
adverse
effects
during
trial.
In
conclusion,
has
significant
clinical
impact
preventing
adult
aging.
