Archives of Gerontology and Geriatrics Plus, Год журнала: 2024, Номер unknown, С. 100117 - 100117
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Translational Autoimmunity, Год журнала: 2024, Номер 8, С. 100237 - 100237
Опубликована: Март 2, 2024
Autoimmune diseases (ADs) are one of the groups chronic illnesses that impose a significant burden disease and health costs worldwide. Age is crucial risk factor for onset ADs. Theoretically, it inferred with organic immune system aging, loss tolerance specificity activity becomes more intense, probability autoimmunity increasing. However, there group individuals whose prevalence ADs very low or non-existent, despite biological aging. This paradox in raises questions. Centenarians, who over 100 years old, possibly most successful model aging humans. Most these exhibit favorable phenotype. To date, primary data evidence potential hypotheses explaining this phenomenon lacking globally, even though could provide valuable, original, relevant information regarding understanding protective factors, drivers, biomarkers related to autoimmunity. Herein we discuss some hypothesis may explain absence centenarians, including inflammaging, immunosenescence resilience, hyperstimulation, proteodynamics, genetics.
Язык: Английский
Процитировано
6
Nature Aging, Год журнала: 2024, Номер 4(3), С. 277 - 278
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
4
Annals of Geriatric Medicine and Research, Год журнала: 2024, Номер 28(2), С. 144 - 155
Опубликована: Апрель 8, 2024
Centenarians are considered the most successful human biological aging model. However, characteristics and patterns of research among centenarians have not been described or analyzed. Thus, this study aimed to disclose historical landscape global on centenarians.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 6, 2025
This document determines the causes of mortality (2008–2022) and calculate per capita health expenditure (2013–2021) in octogenarians, nonagenarians centenarians Colombian population, considering year, gender age group. For this nationwide retrospective descriptive observational study, epidemiological regions, urban/rural areas morbidities were also studied. A mean 75,552 deaths was observed from 2008 to 2022. Deaths higher due ischemic heart disease, COVID-19, chronic obstructive pulmonary cancer, cerebrovascular diseases oldest old population with urban having rates than rural (an average 948 (min: 847, max: 1207) against 630 558, 789) 10,000 people, respectively). Conditions diseases, influenza pneumonia disease most expensive care, summing above 5000 purchasing power parity USD on 2234, 7539). These conditions, along hypertension diabetes mellitus, frequently recorded. COVID-19 incurred compared (1090 vs. 519 High prevalence (14·3%) medical attention (16·8 care utilisations capita) shown for organic mental disorders. Our analysis found that survived more octogenarians nonagenarians, several hypotheses attributing their immune profiles. We high HIV/AIDS among older males suggesting need further study sexually transmitted prevention population. Lastly, Alzheimer's particularly areas, had substantial expenditure. Therefore, neurodegenerative impact stressful events must be priorities system ensure adequate resource management.
Язык: Английский
Процитировано
0
Australasian Journal on Ageing, Год журнала: 2025, Номер 44(1)
Опубликована: Фев. 24, 2025
The aim of this study was to evaluate the association between home care and health phenotype Colombian centenarians. Cross-sectional derived from Centenarian Cohort Study (COOLCEN Cohort). Through random sampling, centenarians their families were identified interviewed in person assess specific characteristics care. Fifty included study, with an average age 100.9 years. Of these, 74% women 96% beneficiaries a subsidised health-care system. Eighty-six percent had at least one chronic disease, arterial hypertension being most prevalent (86%), 60% classified as frail older adult, exhibited signs sarcopenia, 42% experienced fall past year, 26% good nutritional status, 28% polypharmacy. Centenarians who did not receive more likely be free co-morbidities (29% vs. 8%), lower frequency frailty (50% 75%), sarcopenia 64%), malnutrition (14% 39%), greater independence (43% 11%) better functional performance 11%). Receiving care, whether monthly or comprehensive, associated any outcomes. Under current model, there no for No centenarian without received preventive However, population faces socio-economic challenges needs that could benefit education implementation primary interventions, regardless presence comorbidities.
Язык: Английский
Процитировано
0
Surgery, Год журнала: 2025, Номер 182, С. 109336 - 109336
Опубликована: Март 29, 2025
The utility of procalcitonin for detecting anastomotic leaks after colorectal surgery in older adults has not been well documented. As the immune system undergoes changes with age, levels may differ at baseline, and its diagnostic performance could vary when an leak occurs adult patients cancer. aim this study is to evaluate on postoperative day 3 We conducted a test basis delayed-type cross-sectional design (≥65 years old) Postoperative were tested. reference standard was leak. calculated receiver operating characteristic curve area under curve. incidence 7.7%. On 3, demonstrated 0.68 (95% confidence interval, 0.58-0.78) prediction using levels. cutoff point greatest performance, according Youden index, 0.61 ng/mL, sensitivity 0.69, specificity 0.62, positive likelihood ratio 1.86, negative 0.48 predicting 0.78 ileostomies excluded 0.81 evaluating grade C leaks. Our reveals that are poor marker identifying cancer, improvement subgroup.
Язык: Английский
Процитировано
0
Aging Medicine, Год журнала: 2024, Номер 7(4), С. 446 - 448
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
1
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(24), С. 7678 - 7678
Опубликована: Дек. 17, 2024
Background: Although the current literature has shown an increasing interest in surgical treatment of gastric cancer (GC) older adults recent years, there is still no consensus on proper management this subgroup patients. This study was designed with objective evaluating evidence that compares limited lymph node dissection extended adult patients (≥65 years) coursing resectable GC. Methods: A systematic review PubMed, Cochrane library, and ScienceDirect performed according to PRISMA guidelines. All studies before 2018 were selected using a by Mogal et al. Studies eligible for meta-analysis if they randomized controlled trials or non-randomized comparative comparing versus GC taken gastrectomy. Results: Seventeen total 5056 included. There not any statistically significant differences OS (HR = 1.04, CI95% 0.72–1.51), RFS 0.92, 0.62–1.38), CSS 1.24, 0.74–2.10) between lymphadenectomy addition gastrectomy as higher rate major complications observed group, difference incidence both groups (OR 1.92, 0.75–4.91). Conclusions: Limited must be considered better recommendation patients, considering oncological outcomes lower rates compared more radical dissections.
Язык: Английский
Процитировано
0
Archives of Gerontology and Geriatrics Plus, Год журнала: 2024, Номер unknown, С. 100117 - 100117
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0