SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis

American Journal of Obstetrics and Gynecology, Год журнала: 2021, Номер 226(1), С. 68 - 89.e3

Опубликована: Июль 21, 2021

To examine the relationship between SARS-CoV-2 infection during pregnancy and risk for preeclampsia.

Язык: Английский

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COVID-19 in pregnancy: implications for fetal brain development

Trends in Molecular Medicine, Год журнала: 2022, Номер 28(4), С. 319 - 330

Опубликована: Фев. 14, 2022

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on the developing fetal brain is poorly understood. Other antenatal infections such as influenza have been associated with adverse neurodevelopmental outcomes in offspring. Although vertical transmission has rarely observed SARS-CoV-2 to date, given potential for profound maternal immune activation (MIA), likely. Here we review evidence that and other viral can result maternal, placental, activation, ultimately offspring morbidity. Finally, highlight need cellular models development better understand short- long-term impacts next generation.

Язык: Английский

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The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

Nature Immunology, Год журнала: 2021, Номер 22(12), С. 1490 - 1502

Опубликована: Окт. 6, 2021

Язык: Английский

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COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy

Translational research, Год журнала: 2022, Номер 251, С. 84 - 95

Опубликована: Авг. 12, 2022

Язык: Английский

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Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Сен. 27, 2022

SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant and have a higher adverse pregnancy outcomes like intrauterine/fetal distress preterm birth. However, little is known about the impact infection on maternal neonatal immunological profiles. In this study, we investigated inflammatory humoral responses to in cord blood paired samples. Thirty-six were recruited delivery Hospital Sant Joan de Déu, Barcelona, Spain, between April-August 2020, before having available vaccines. Maternal variables, as well perinatal outcomes, recorded questionnaires. Nasopharyngeal swabs samples collected for detection by rRT-PCR serology, respectively. We measured IgM, IgG IgA levels 6 antigens (spike [S], S1, S2, receptor-binding domain [RBD], nucleocapsid [N] full-length C-terminus), N from 4 human coronaviruses (OC43, HKU1, 229E NL63), concentrations 30 cytokines, chemokines growth factors Luminex. Mothers classified or non-infected based serology results. Sixty-four % with (positive during third trimester and/or just after delivery). None newborns tested positive rRT-PCR. mothers had virus-specific antibodies several cytokines. Those symptoms cytokine levels. IFN-α was mothers, symptomatic EGF, FGF, IL-17 IL-15 increased, whereas RANTES decreased. showed correlations their counterparts blood. lower transfer SARS-CoV-2-specific IgGs, stronger effect when closer delivery. carrying male fetus antibody IL-7 concentrations. Our results show that induces robust response causes significant reduction IgGs transplacental transfer, negative

Язык: Английский

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COVID‐19 disease and vaccination in pregnant and lactating women

American Journal of Reproductive Immunology, Год журнала: 2022, Номер 88(1)

Опубликована: Апрель 22, 2022

Abstract Background More than 325,000 cases of coronavirus disease 2019 (COVID‐19) have been reported among pregnant women in the Americas. Aims This review examines impact COVID‐19 and describes available evidence on safety, effectiveness, immune response(s) to vaccination lactating women. Content Multiple studies indicate that are more susceptible adverse outcomes, including hospitalization, intensive care unit admission, invasive ventilation non‐pregnant with COVID‐19. Furthermore, pregnancy is associated maternal neonatal outcomes. Adverse outcomes appear disproportionately affect from low‐ middle‐income countries, likely reflecting inequities access quality healthcare. Despite absence safety efficacy data randomized clinical trials this subpopulation, observational registries thus far demonstrated or against safe, effective, results robust responses transfer antibodies newborn via placenta breast milk, respectively. Implications These support recommendations intending help protect these vulnerable individuals its sequelae. Randomized will further evaluate immunogenicity vaccines populations.

Язык: Английский

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Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*

Immunological Reviews, Год журнала: 2022, Номер 308(1), С. 123 - 148

Опубликована: Апрель 4, 2022

Abstract Pregnant women infected with pathogenic respiratory viruses, such as influenza A viruses (IAV) and coronaviruses, are at higher risk for mortality, hospitalization, preterm birth, stillbirth. Several factors likely to contribute the susceptibility of pregnant individuals severe lung disease including changes in pulmonary physiology, immune defenses, effector functions some cells. Pregnancy is also a physiologic state characterized by levels multiple hormones that may impact cells, progesterone, estrogen, human chorionic gonadotropin, prolactin, relaxin. Each these acts support tolerogenic pregnancy, which helps prevent fetal rejection, but an impaired antiviral response. In this review, we address unique role adaptive innate cells control how pregnancy specific can their actions. We highlight sex‐specific differences infection outcomes why protection aid virus expense mother's health.

Язык: Английский

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Immune Responses to SARS-CoV-2 in Pregnancy: Implications for the Health of the Next Generation

The Journal of Immunology, Год журнала: 2022, Номер 209(8), С. 1465 - 1473

Опубликована: Окт. 15, 2022

Abstract Widespread SARS-CoV-2 infection among pregnant individuals has led to a generation of fetuses exposed in utero, but the long-term impact such exposure remains unknown. Although fetal is rare, children born mothers with may be at increased risk for adverse neurodevelopmental and cardiometabolic outcomes. Fetal programming effects are likely mediated least part by maternal immune activation. In this review, we discuss recent evidence regarding prenatal on maternal, placental, response, as well implications health offspring. Extrapolating from what known about activation other contexts (e.g., obesity, HIV, influenza), review potential morbidity Based available data suggesting risk, highlight importance establishing large cohorts monitor offspring SARS-CoV-2–positive sequelae.

Язык: Английский

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Analysis of Clinical Outcomes of Pregnant Patients Treated With Nirmatrelvir and Ritonavir for Acute SARS-CoV-2 Infection

JAMA Network Open, Год журнала: 2022, Номер 5(11), С. e2244141 - e2244141

Опубликована: Ноя. 29, 2022

Importance Pregnant people are at increased risk of poor outcomes due to infection with SARS-CoV-2, and there limited therapeutic options available. Objective To evaluate the clinical associated nirmatrelvir ritonavir used treat SARS-CoV-2 in pregnant patients. Design, Setting, Participants This case series included patients who were diagnosed infection, received ritonavir, delivered their offspring within Johns Hopkins Health System between December 22, 2021, August 20, 2022. Exposures Treatment for during pregnancy. Main Outcomes Measures Clinical characteristics ascertained through manual record review. Results Forty-seven (median [range] age, 34 [22-43] years) study, median (range) gestational age was 28.4 (4.3-39.6) weeks. Medication initiated a 1 (0-5) day after symptom onset, only 2 [4.3%] did not complete course therapy because adverse effects. Thirty (63.8%) treated had comorbidity addition pregnancy that could be factor developing severe COVID-19. Twenty-five [53.2%] treatment ritonavir. Twelve these [48.0%] underwent cesarean delivery, 9 [75.0%] which scheduled. Two 47 hospitalized conditions related preexisting comorbidities. Conclusions Relevance In this series, tolerated well, although an unexpectedly high rate deliveries. The lack increase serious effects affecting or suggests clinicians can use drug combination infection.

Язык: Английский

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SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort

Journal of Reproductive Immunology, Год журнала: 2024, Номер 163, С. 104243 - 104243

Опубликована: Март 18, 2024

Associations between antenatal SARS-CoV-2 infection and pregnancy outcomes have been conflicting the role of immune system is currently unclear. This prospective cohort study investigated interaction infection, changes in cytokine HS-CRP levels, birthweight gestational age at birth. 2,352 pregnant participants from New York City (2020-2022) were included. Plasma levels interleukin (IL)-1β, IL-6, IL-17A high-sensitivity C-reactive protein (HS-CRP) quantified blood specimens obtained across pregnancy. Quantile linear regression models conducted to 1) assess impact overall by timing detection positivity (< 20 weeks versus ≥ weeks), on delivery; 2) examine relationship maternal during All adjusted for demographic obstetric factors pandemic timing. Birthweight additionally delivery fetal sex. Immune marker also specimen collection multiplex assay batch. 371 (15.8%) infected with pregnancy, which 98 (26.4%) < gestation. Neither general nor early or late was associated lower earlier delivery. Further, we did not observe response thus found no evidence support a potential association dysregulation diversity following infection.

Язык: Английский

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