Transcriptomic profiling reveals differential cellular response to copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

Environment International, Год журнала: 2023, Номер 177, С. 108015 - 108015

Опубликована: Июнь 7, 2023

The growing nanoparticulate pollution (e.g. engineered nanoparticles (NPs) or nanoplastics) has been shown to pose potential threats human health. In particular, sensitive populations such as pregnant women and their unborn children need be protected from harmful environmental exposures. However, developmental toxicity prenatal exposure particles is not yet well studied despite evidence of particle accumulation in placenta. Our study aimed investigate how copper oxide NPs (CuO NPs; 10–20 nm) polystyrene nanoplastics (PS 70 impact on gene expression ex vivo perfused placental tissue. Whole genome microarray analysis revealed changes global profile after 6 h perfusion with sub-cytotoxic concentrations CuO (10 µg/mL) PS (25 µg/mL). Pathway ontology enrichment the differentially expressed genes suggested that trigger distinct cellular response While induced pathways related angiogenesis, protein misfolding heat shock responses, affected inflammation iron homeostasis. observed effects misfolding, cytokine signaling, hormones were corroborated by western blot (accumulation polyubiquitinated proteins) qPCR analysis. Overall, results present extensive material-specific interference a single short-term which deserves increasing attention. addition, placenta, often neglected studies, should key focus future safety assessment pregnancy.

Язык: Английский

---

From Birth to Weaning: A Window of Opportunity for Microbiota

Nutrients, Год журнала: 2024, Номер 16(2), С. 272 - 272

Опубликована: Янв. 17, 2024

(1) Background: The first 1000 days of life constitute a critical window opportunity for microbiota development. Nutrients play crucial role in enriching and diversifying the microbiota, derived not only from solid food but also maternal dietary patterns during gestation. (2) Methods: We conducted comprehensive literature review using PubMed database, covering eleven years (2013–2023). included English-language reviews, original research papers, meta-analyses, while excluding case reports letters. (3) Results: Consensus emphasizes that our interaction with multitude microorganisms begins intrauterine environment continues throughout lives. existing data suggest early nutritional education programs, initiated pregnancy guiding infant diets development, may influence shaping gut promoting long-term health. (4) Conclusions: Further is necessary coming to assess potential interventions models aimed at modulating pediatric especially vulnerable populations such as premature newborns.

Язык: Английский

---

Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses

Nutrients, Год журнала: 2024, Номер 16(4), С. 570 - 570

Опубликована: Фев. 19, 2024

Cardiovascular disease (CVD) is a leading cause of mortality and burden in women globally. A healthy diet important for the prevention CVD. Research has consistently favoured Mediterranean as cardio-protective diet. Several studies have evaluated associations between cardiovascular outcomes, including traditional risk factors like hypertension, type 2 diabetes mellitus, obesity. In addition, consistent evidence suggests that components synergistic effect on due to its anti-inflammatory profile microbiome effects. While benefits are well-established, health advice dietary guidelines been built largely male-dominant studies. Few investigated beneficial sex-specific populations, those with non-traditional specific women, instance polycystic ovarian syndrome high-risk pregnancies, or more prevalent such chronic inflammatory diseases. Therefore, this review aims provide comprehensive overview current regarding relation outcomes.

Язык: Английский

---

Smart Solutions for Diet-Related Disease Management: Connected Care, Remote Health Monitoring Systems, and Integrated Insights for Advanced Evaluation

Applied Sciences, Год журнала: 2024, Номер 14(6), С. 2351 - 2351

Опубликована: Март 11, 2024

The prevalence of diet-related diseases underscores the imperative for innovative management approaches. deployment smart solutions signifies a paradigmatic evolution, capitalising on advanced technologies to enhance precision and efficacy. This paper aims present explore diseases, focusing leveraging technologies, such as connected care, Internet Medical Things (IoMT), remote health monitoring systems (RHMS), address rising diseases. transformative approach is exemplified in case studies tailored RHMS capabilities. showcase potential three introducing novel evaluation method their customisation proactive conditions influenced by dietary habits. RO-SmartAgeing System uniquely addresses age-related aspects, providing an integrated that considers long-term impact choices ageing, marking perspective healthcare. NeuroPredict Platform, complex neuroinformatics, enhances understanding connections between brain health, nutrition, overall well-being, contributing insights healthcare assessments. Focused liver monitoring, HepatoConect system delivers real-time data personalized recommendations, offering distinctive disease management. By integrating cutting-edge these transcend traditional boundaries.

Язык: Английский

---

Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food

Phytochemistry Reviews, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 2, 2024

Язык: Английский

---

A Review on Factors Affecting and Performance of Nutritional Security of Women and Children in India

Advances in environmental engineering and green technologies book series, Год журнала: 2024, Номер unknown, С. 364 - 397

Опубликована: Июнь 28, 2024

This chapter describes the performance of nutritional security women and children's representative indicators in India. The cross-comparison children across Indian states are also explained. It assesses impact feeding on India using a state-wise pooled panel data. is food self-sufficient country; despite that, it has large number nutritionally insecure children. There exists diversity status states. Women found to be significant indicator increase findings this attention policy makers government initiate effective policies reduce malnutritional provides scope further research

Язык: Английский

---

Considering the use of GLP-1 receptor agonists in women with obesity prior to pregnancy: a narrative review

Archives of Gynecology and Obstetrics, Год журнала: 2025, Номер 311(5), С. 1241 - 1247

Опубликована: Янв. 7, 2025

Abstract Purpose Metabolic disease, including obesity and type 2 diabetes, are amongst the most significant health issues facing women of reproductive age. To date, no antenatal weight management tools have reduced risk adverse outcomes for with their offspring, resulting in a shift focus to pre-conception period. Although not yet recognised international guidelines, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) being increasingly used prior conception. Methods A literature search PubMed, Medline, Embase databases identified relevant articles describing use GLP-1 RAs during pregnancy. Papers were selected based on relevance originality, clinical trials, large observational studies meta-analyses preferentially included. Results This narrative review summarises mechanism action effects observed non-pregnant adults. It synthesises available data from human animal regarding safety efficacy pregnancy, consequences inadvertent drug exposure early In considering need balance risks metabolic disease posed by exposure, it highlights areas where further research is needed guide decision-making. Conclusion may role facilitating loss improving However, there currently insufficient evidence demonstrate that this class drugs pregnancy improves outcomes.

Язык: Английский

---

Limitations of the indicator amino acid oxidation method for determining amino acid requirements

American Journal of Clinical Nutrition, Год журнала: 2025, Номер 121(2), С. 497 - 499

Опубликована: Янв. 9, 2025

Язык: Английский

---

International expert consensus on micronutrient supplement use during the early life course

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 20, 2025

Abstract Background Growing evidence demonstrates that maternal nutrition is crucial for the health of mother-to-be, and early life course offspring. However, most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate level expert consensus on micronutrient needs during preconception, pregnancy lactation. Methods We conducted a two-round web-based survey various topics including general approaches diet supplement use, existing guidelines. For periods lactation, questions focused importance strength use with following micronutrients low- high-risk populations: folic acid, choline, iodine, magnesium, calcium, iron, selenium, docosahexaenoic acid (DHA), vitamins B1, B2, B6, B12, D K. Results Thirty-five experts participated in panel, who were healthcare professionals (HCPs), researchers joint HCP-researchers expertise nutrition, gynaecology and/or obstetrics. Panellists reached dietary agreed lack clarity consistency current guidelines, need education these areas HCPs, pregnant people population. low-risk populations, there was iron vitamin from preconception through iodine second third trimesters, respectively, DHA first trimester lactation calcium each phases improve outcomes foetal development strong, except (preconception), (first trimester), (both periods). There also advice should be tailored vegan/vegetarian diets, restricted diets due food intolerances, obesity, polycystic ovary syndrome, diabetes mellitus, previous nutrition-related complications. Conclusion The findings revealed robust aspects education, across specific at-risk groups requiring approaches.

Язык: Английский

---

Food Insecurity in Pregnancy, Receipt of Food Assistance, and Perinatal Complications

JAMA Network Open, Год журнала: 2025, Номер 8(1), С. e2455955 - e2455955

Опубликована: Янв. 23, 2025

Importance Food insecurity is a growing public health concern, but its association with perinatal complications remains unclear. Objective To examine whether food in pregnancy was associated the risk of and determine these potential associations differed by receipt assistance. Design, Setting, Participants This cohort study used data from survey conducted between June 22, 2020, September 9, 2022, at Kaiser Permanente Northern California, an integrated care system serving diverse population 4.6 million. included individuals who delivered singletons. Data were analyzed December 2023 to 2024. Exposure assessed using validated 2-item Hunger Vital Sign screener. Main Outcomes Measures Maternal (gestational diabetes, gestational hypertension, preeclampsia, cesarean delivery) neonatal (preterm birth, intensive unit [NICU] admission, small-for-gestational age [SGA], large-for-gestational [LGA]) extracted electronic records, composite adverse outcome (APO) maternal complications. Modified Poisson regression models adjusted for covariates stratified assistance pregnancy. Results Among 19 338 individuals, 2707 (14.0%) reported Individuals had higher diabetes (adjusted relative [aRR], 1.13 [95% CI, 1.01-1.29]), preeclampsia (aRR, 1.28 1.11-1.49]), preterm birth 1.19 1.02-1.38]), NICU admission 1.23 1.07-1.42]), APO 1.07 1.02-1.13]) compared without insecurity. 1471 (7.6%) received pregnancy, attenuated null, except 1.64 1.06-2.53]). On contrary, persisted among did not receive assistance: 1.20 1.04-1.37]), 1.24 1.06-1.46]), 1.05-1.46]), 1.31 1.12-1.52]), 1.12 1.06-1.18]). Conclusions Relevance In this study, complications, overall null These findings support clinical guidelines screening provide evidence expand programs that may help improve outcomes.

Язык: Английский

---