Pregnancy outcomes among Indian women: increased prevalence of miscarriage and stillbirth during 2015–2021

BMC Pregnancy and Childbirth, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 8, 2023

Pregnancy outcome is an important health indicator of the quality maternal health. Adverse pregnancy outcomes a major public problem, which can lead to poor and neonatal outcomes. This study investigates trends in prevalent during 2015-2021 Indian women.The analysed data presented fourth (2015-16) fifth (2019-21) rounds National Family Health Survey (NFHS). The absolute relative changes birth last five years preceding surveys were estimated using collected from 195,470 women NFHS-4 255,549 NFHS-5.Livebirth decreased by 1.3 points (90.2% vs. 88.9%), nearly half states/UTs (n = 17/36) had lower than national average livebirth (88.9%) reported 2019-21. A higher proportion loss was noted, particularly miscarriages increased both urban (6.4% 8.5%) rural areas (5.3% 6.9%), stillbirth 28.6% (0.7% 0.9%). number abortions (3.4% 2.9%) among women. Nearly due unplanned pregnancies (47.6%) more one-fourth (26.9%) performed self. Abortions adolescent Telangana eleven times 2019-21 as compared 2015-16 (8.0% 0.7%).Our presents evidence decrease increase frequency miscarriage 2015-2021. emphasises that there need regional-specific, comprehensive healthcare programs for improving

Language: Английский

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Care plan for individuals at risk for preeclampsia: shared approach to education, strategies for prevention, surveillance, and follow-up

American Journal of Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: 229(3), P. 193 - 213

Published: April 27, 2023

Preeclampsia is a multisystemic disorder of pregnancy that affects 250,000 pregnant individuals in the United States and approximately 10 million worldwide per annum. associated with substantial immediate morbidity mortality but also long-term for both mother offspring. It now clearly established low dose aspirin given daily, beginning early modestly reduces occurrence preeclampsia. Low-dose seems safe, because there paucity information about effects on infant, it not recommended all individuals. Thus, several expert groups have identified clinical factors indicate sufficient risk to recommend low-dose preventive therapy. These may be complemented by biochemical and/or biophysical tests either increased probability preeclampsia factors, or more importantly, identify likelihood those without other evident risk. In addition, opportunity exists provide this population additional care prevent mitigate short- Patient provider education, surveillance, behavioral modification, approaches improve outcomes these can chance healthy outcome. We assembled group diverse, relevant expertise (clinicians, investigators, advocates, public private stakeholders) develop plan which providers at work together reduce morbidities. The moderate high developing preeclampsia, receive therapy, as laboratory findings. recommendations are presented using GRADE methodology quality evidence upon each based. printable appendices concise summaries plan's patients healthcare provided. believe shared approach will facilitate prevention its attendant development disorder.

Language: Английский

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Transcriptomic profiling reveals differential cellular response to copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

Environment International, Journal Year: 2023, Volume and Issue: 177, P. 108015 - 108015

Published: June 7, 2023

The growing nanoparticulate pollution (e.g. engineered nanoparticles (NPs) or nanoplastics) has been shown to pose potential threats human health. In particular, sensitive populations such as pregnant women and their unborn children need be protected from harmful environmental exposures. However, developmental toxicity prenatal exposure particles is not yet well studied despite evidence of particle accumulation in placenta. Our study aimed investigate how copper oxide NPs (CuO NPs; 10–20 nm) polystyrene nanoplastics (PS 70 impact on gene expression ex vivo perfused placental tissue. Whole genome microarray analysis revealed changes global profile after 6 h perfusion with sub-cytotoxic concentrations CuO (10 µg/mL) PS (25 µg/mL). Pathway ontology enrichment the differentially expressed genes suggested that trigger distinct cellular response While induced pathways related angiogenesis, protein misfolding heat shock responses, affected inflammation iron homeostasis. observed effects misfolding, cytokine signaling, hormones were corroborated by western blot (accumulation polyubiquitinated proteins) qPCR analysis. Overall, results present extensive material-specific interference a single short-term which deserves increasing attention. addition, placenta, often neglected studies, should key focus future safety assessment pregnancy.

Language: Английский

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Call to action for a life course approach

The Lancet, Journal Year: 2024, Volume and Issue: 404(10448), P. 193 - 214

Published: June 20, 2024

Language: Английский

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From Birth to Weaning: A Window of Opportunity for Microbiota

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 272 - 272

Published: Jan. 17, 2024

(1) Background: The first 1000 days of life constitute a critical window opportunity for microbiota development. Nutrients play crucial role in enriching and diversifying the microbiota, derived not only from solid food but also maternal dietary patterns during gestation. (2) Methods: We conducted comprehensive literature review using PubMed database, covering eleven years (2013–2023). included English-language reviews, original research papers, meta-analyses, while excluding case reports letters. (3) Results: Consensus emphasizes that our interaction with multitude microorganisms begins intrauterine environment continues throughout lives. existing data suggest early nutritional education programs, initiated pregnancy guiding infant diets development, may influence shaping gut promoting long-term health. (4) Conclusions: Further is necessary coming to assess potential interventions models aimed at modulating pediatric especially vulnerable populations such as premature newborns.

Language: Английский

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Cardiovascular Disease and the Mediterranean Diet: Insights into Sex-Specific Responses

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 570 - 570

Published: Feb. 19, 2024

Cardiovascular disease (CVD) is a leading cause of mortality and burden in women globally. A healthy diet important for the prevention CVD. Research has consistently favoured Mediterranean as cardio-protective diet. Several studies have evaluated associations between cardiovascular outcomes, including traditional risk factors like hypertension, type 2 diabetes mellitus, obesity. In addition, consistent evidence suggests that components synergistic effect on due to its anti-inflammatory profile microbiome effects. While benefits are well-established, health advice dietary guidelines been built largely male-dominant studies. Few investigated beneficial sex-specific populations, those with non-traditional specific women, instance polycystic ovarian syndrome high-risk pregnancies, or more prevalent such chronic inflammatory diseases. Therefore, this review aims provide comprehensive overview current regarding relation outcomes.

Language: Английский

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Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

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Smart Solutions for Diet-Related Disease Management: Connected Care, Remote Health Monitoring Systems, and Integrated Insights for Advanced Evaluation

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 2351 - 2351

Published: March 11, 2024

The prevalence of diet-related diseases underscores the imperative for innovative management approaches. deployment smart solutions signifies a paradigmatic evolution, capitalising on advanced technologies to enhance precision and efficacy. This paper aims present explore diseases, focusing leveraging technologies, such as connected care, Internet Medical Things (IoMT), remote health monitoring systems (RHMS), address rising diseases. transformative approach is exemplified in case studies tailored RHMS capabilities. showcase potential three introducing novel evaluation method their customisation proactive conditions influenced by dietary habits. RO-SmartAgeing System uniquely addresses age-related aspects, providing an integrated that considers long-term impact choices ageing, marking perspective healthcare. NeuroPredict Platform, complex neuroinformatics, enhances understanding connections between brain health, nutrition, overall well-being, contributing insights healthcare assessments. Focused liver monitoring, HepatoConect system delivers real-time data personalized recommendations, offering distinctive disease management. By integrating cutting-edge these transcend traditional boundaries.

Language: Английский

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A Review on Factors Affecting and Performance of Nutritional Security of Women and Children in India

Advances in environmental engineering and green technologies book series, Journal Year: 2024, Volume and Issue: unknown, P. 364 - 397

Published: June 28, 2024

This chapter describes the performance of nutritional security women and children's representative indicators in India. The cross-comparison children across Indian states are also explained. It assesses impact feeding on India using a state-wise pooled panel data. is food self-sufficient country; despite that, it has large number nutritionally insecure children. There exists diversity status states. Women found to be significant indicator increase findings this attention policy makers government initiate effective policies reduce malnutritional provides scope further research

Language: Английский

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International expert consensus on micronutrient supplement use during the early life course

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 20, 2025

Abstract Background Growing evidence demonstrates that maternal nutrition is crucial for the health of mother-to-be, and early life course offspring. However, most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate level expert consensus on micronutrient needs during preconception, pregnancy lactation. Methods We conducted a two-round web-based survey various topics including general approaches diet supplement use, existing guidelines. For periods lactation, questions focused importance strength use with following micronutrients low- high-risk populations: folic acid, choline, iodine, magnesium, calcium, iron, selenium, docosahexaenoic acid (DHA), vitamins B1, B2, B6, B12, D K. Results Thirty-five experts participated in panel, who were healthcare professionals (HCPs), researchers joint HCP-researchers expertise nutrition, gynaecology and/or obstetrics. Panellists reached dietary agreed lack clarity consistency current guidelines, need education these areas HCPs, pregnant people population. low-risk populations, there was iron vitamin from preconception through iodine second third trimesters, respectively, DHA first trimester lactation calcium each phases improve outcomes foetal development strong, except (preconception), (first trimester), (both periods). There also advice should be tailored vegan/vegetarian diets, restricted diets due food intolerances, obesity, polycystic ovary syndrome, diabetes mellitus, previous nutrition-related complications. Conclusion The findings revealed robust aspects education, across specific at-risk groups requiring approaches.

Language: Английский

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