Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance

Journal of Hazardous Materials, Год журнала: 2022, Номер 445, С. 130393 - 130393

Опубликована: Ноя. 14, 2022

Язык: Английский

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Adsorptive and photocatalytic degradation potential of porous polymeric materials for removal of pesticides, pharmaceuticals, and dyes-based emerging contaminants from water

Chemosphere, Год журнала: 2023, Номер 336, С. 139203 - 139203

Опубликована: Июнь 12, 2023

Язык: Английский

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Surfactants – Compounds for inactivation of SARS-CoV-2 and other enveloped viruses

Current Opinion in Colloid & Interface Science, Год журнала: 2021, Номер 55, С. 101479 - 101479

Опубликована: Июнь 12, 2021

Язык: Английский

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The COVID-19 Pathway: A Proposed Oral-Vascular-Pulmonary Route Of SARS-CoV-2 Infection And The Importance Of Oral Healthcare Measures

Journal Of Oral Medicine And Dental Research, Год журнала: 2021, Номер 2(1), С. 1 - 25

Опубликована: Апрель 20, 2021

Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in late 2019, world has faced a major healthcare challenge.There remains limited understanding reasons for clinical variability disease 2019 (COVID-19), and lack biomarkers to identify individuals at risk developing lung disease.This article aims present hypothesis on vascular route transfer SARS-CoV-2 from oral cavity lungs.Saliva is reservoir SARS-CoV-2, thus any breach immune defenses mouth may facilitate entrance virus vasculature through gingival sulcus or periodontal pocket.From vasculature, would pass veins neck chest, reach heart, being pumped into pulmonary arteries, small vessels

Язык: Английский

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The effectiveness of mouthwash against SARS-CoV-2 infection: A review of scientific and clinical evidence

Journal of the Formosan Medical Association, Год журнала: 2021, Номер 121(5), С. 879 - 885

Опубликована: Окт. 9, 2021

The COVID-19 pandemic, caused by the spread of SARS-CoV-2 infection that is mainly through airborne transmission, a worldwide health concern. This review seeks to assess potential effectiveness mouthwash in reducing oropharyngeal load based on available evidence. Articles related and PubMed were electronically searched July, 2021. After manually excluding articles lacking sufficient scientific evidence or validation processes, those with inaccessible online full text, did not test against SARS-CoV-2, written English, 17 original 13 chosen for this review. eligible revealed main virucidal mechanism was via interactions viral envelope. Povidone-iodine (PVP-I), cetylpyridinium chloride (CPC), essential oils ethanol showed effects vitro, potentially interfering A few clinical studies demonstrated PVP-I, CPC, hydrogen peroxide, chlorhexidine reduced SARS-CoV-2. Although limited, containing PVP-I CPC shows thus may present risk-mitigation strategy patients.

Язык: Английский

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Virucidal efficacy of chlorhexidine: a systematic review

Odontology, Год журнала: 2021, Номер 110(2), С. 376 - 392

Опубликована: Окт. 12, 2021

Язык: Английский

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Chlorhexidine mouthwash reduces the salivary viral load of SARS‐CoV‐2: A randomized clinical trial

Oral Diseases, Год журнала: 2021, Номер 28(S2), С. 2500 - 2508

Опубликована: Ноя. 27, 2021

This study aimed to evaluate the effect of 0.12% chlorhexidine gluconate on salivary load SARS-CoV-2.A randomized, double-blind, placebo-controlled trial was performed 100 participants positive for SARS-CoV-2. In test group (n = 50), volunteers gargled with a mouthwash containing 15 ml 1 min, while control 50) used placebo. Saliva samples were obtained before (baseline) and 5 60 min after using solutions. Real-time reverse transcription polymerase chain reaction assays (qRT-PCR) carried out cycle threshold (Ct) computed. The chi-square t-test comparison (p ≤ 0.05).The differences in Ct values between 5-min evaluation baseline (test group: 2.19 ± 4.30; control: -0.40 3.87, p 0.002) 2.45 3.88; 0.76 4.41, 0.05) significantly greater group, revealing reduction viral load. Furthermore, there SARS-CoV-2 72% versus 30% 0.001).Chlorhexidine (0.12%) effective reducing at least min.

Язык: Английский

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Antiviral effect of mouthwashes against SARS-COV-2: A systematic review

The Saudi Dental Journal, Год журнала: 2022, Номер 34(3), С. 167 - 193

Опубликована: Фев. 1, 2022

This systematic review aimed to evaluate the antiviral effect of mouthwashes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An electronic search was performed on PubMed, Scopus, Web Science, Cochrane Library, LILACS, ProQuest, and Google Scholar, complemented by a manual search. Both clinical in vitro studies that focused SARS-CoV-2 were included. Risk bias assessment only using RoB-2 ROBINS-I tools. A total 907 records found; after initial selection title abstract, 33 full-text articles selected be evaluated for eligibility. Finally, 27 included qualitative synthesis, including 16 11 trials. Antiviral effects separately studies. In containing hydrogen peroxide, chlorhexidine digluconate, povidone-iodine, essential oils, cetylpyridinium chloride, other compounds; vivo chlorine dioxide, β-cyclodextrin-citrox, sorbitol with xylitol. Povidone-iodine, oils effective vitro, while xylitol vivo. Unclear or high risk found almost all studies, one study presented low bias. No further quantitative analysis performed. Although may an alternative reduce viral load vivo, more are needed determine real these different SARS-CoV-2. work not funded. The protocol registered PROSPERO (identification number: CRD42021236134).

Язык: Английский

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Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Авг. 18, 2022

Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 µg/mL). Interestingly, we found that suppressed infectivity human isolated strains (Wuhan, Alpha, Beta, Gamma) even saliva. Furthermore, demonstrated shows anti-SARS-CoV-2 effects without disrupting virus envelope, using sucrose density analysis electron microscopic examination. In conclusion, this provided experimental evidence may inhibit infection lower concentrations.

Язык: Английский

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Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial

Emerging Microbes & Infections, Год журнала: 2022, Номер 11(1), С. 1833 - 1842

Опубликована: Июль 7, 2022

ABSTRACTBackground: In vitro studies have shown that several oral antiseptics virucidal activity against SARS-CoV-2. Thus, mouthwashes been proposed as an easy to implement strategy reduce viral transmission. However, there are no data measuring SARS-CoV-2 viability after in vivo.In this randomized double-blind, five-parallel-group, placebo-controlled clinical trial, salivary load (by quantitative PCR) and its infectious capacity (incubating saliva cell cultures) evaluated before four different antiseptic placebo 54 COVID-19 patients.Contrary evidence, was not affected by any of the tested mouthwashes. Viral culture indicated cetylpyridinium chloride (CPC) significantly reduced infectivity, but only at 1-hour post-mouthwash.These results indicate some currently used infectivity efficient vivo and, furthermore, effect is immediate, generating a false sense security.Trial registration: ClinicalTrials.gov identifier: NCT04707742..

Язык: Английский

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