Journal of Psychiatric Research,
Год журнала:
2025,
Номер
185, С. 169 - 176
Опубликована: Март 29, 2025
Memory
function
impairment
is
severe
in
patients
with
schizophrenia,
but
improving
memory
remains
challenging.
The
use
of
benzodiazepines
and
anticholinergics,
which
are
not
recommended
by
pharmacological
therapy
guidelines
for
has
been
associated
worsened
cognitive
function.
However,
it
unclear
whether
better
adherence
psychiatrists
to
schizophrenia
improved
Therefore,
we
investigated
the
relationship
between
psychiatrists'
schizophrenia.
To
evaluate
associations
function,
utilized
Individual
Fitness
Score
(IFS),
includes
multiple
quality
indicators,
assess
each
psychiatrist's
these
treating
patient.
was
measured
using
Wechsler
Scale-Revised
a
total
351
patients,
including
40
treatment-resistant
(TRS)
311
non-TRS.
We
found
that
psychiatrist
significantly
positively
correlated
verbal
(β
=
0.145,
p
6.45
×
10-3),
attention/concentration
0.138,
0.010),
delayed
recall
0.167,
1.57
10-3)
all
Additionally,
nominal
positive
correlation
observed
visual
0.124,
0.019).
In
non-TRS
0.166,
3.17
nominally
0.141,
0.013)
0.114,
0.044)
functions.
contrast,
no
significant
were
any
functions
TRS.
These
findings
suggest
enhancing
guideline
education
might
improve
impairments
The International Journal of Neuropsychopharmacology,
Год журнала:
2025,
Номер
28(4)
Опубликована: Март 28, 2025
The
rate
of
antipsychotic
polypharmacy
is
high.
One
risk
factor
for
may
be
the
severity
schizophrenia,
including
treatment-resistant
schizophrenia
(TRS).
We
hypothesized
that
institutions
are
able
to
prescribe
clozapine
present
differences
in
pharmacological
treatment
even
before
TRS
diagnosed.
A
total
8155
patients
with
were
divided
into
clozapine-available
institution
(CAI)
group
and
clozapine-unavailable
(CUI)
group.
psychotropic
prescription
rates
at
discharge
compared
between
two
groups.
Furthermore,
investigate
whether
diagnosis
subgroups
influenced
efficacy,
we
CAIs
CUIs
descriptions
(DSTRS)
those
without
(NDSTRS).
Compared
CUI
group,
both
monotherapy
(58.3%
vs.
50.7%;
p
=
2.4
×
10-7)
concomitant
use
other
psychotropics
(20.4%
15.6%;
3.8
10-5)
significantly
higher
CAI
DSTRS
(63.3%)
was
than
NDSTRS
(54.5%;
1.4
10-12),
(49.6%;
4.9
10-9),
(50.9%;
2.0
10-8).
(22.6%)
also
(18.7%;
4.7
10-4),
(15.9%;
5.5
(15.2%;
8.0
10-5).
There
no
significant
difference
these
Both
availability
prescriptions
precise
can
promote
development
an
organizational
culture
facilitates
schizophrenia.
The International Journal of Neuropsychopharmacology,
Год журнала:
2022,
Номер
25(10), С. 818 - 826
Опубликована: Июнь 20, 2022
Abstract
Background
Although
clozapine
is
effective
for
treatment-resistant
schizophrenia
(TRS),
the
rate
of
prescription
still
low.
Whereas
antipsychotic
monotherapy
recommended
in
clinical
practice
guidelines,
polypharmacy
high.
There
little
evidence
on
whether
a
influences
changes
and
polypharmacy,
including
antipsychotics
other
psychotropics.
We
therefore
hypothesized
that
patients
with
TRS
who
were
prescribed
would
be
higher
than
not
clozapine.
Methods
assessed
8306
nationwide
from
178
institutions
Japan
2016
to
2019.
analyzed
psychotropic
data
at
discharge
diagnosed
no
description
(ND-TRS)
based
diagnosis
listed
summary.
Results
The
group
(91.3%)
was
significantly
without
(45.9%;
P
<
2.0
×
10−16)
ND-TRS
(54.7%;
10−16).
any
concomitant
psychotropics
(26.5%)
(12.6%;
=
1.1
10−6)
(17.0%;
5.9
10−6).
Conclusions
Clozapine
could
associated
high
monotherapy.
Patients
will
benefit
correct
thus
proper
prescription.
Neuropsychopharmacology Reports,
Год журнала:
2021,
Номер
42(1), С. 3 - 9
Опубликована: Дек. 2, 2021
Abstract
Background
The
decision
to
initiate
clozapine
treatment
should
be
made
on
an
individual
basis
and
may
closely
related
the
early
detection
of
treatment‐resistant
schizophrenia
(TRS),
although
there
is
evidence
that
use
results
in
a
better
response
treatment.
Therefore,
we
investigated
relationship
between
examination
rate
TRS
prescription
clozapine.
Methods
After
attending
1‐day
educational
program
based
"Guidelines
for
Pharmacological
Treatment
Schizophrenia,"
asked
participating
facilities
submit
records
whether
or
not
was
evaluated
each
patient.
We
calculated
from
schizophrenic
patients
prescribed
all
patients.
Forty‐nine
2017
were
included
study.
Results
There
dichotomous
distributions
non‐normal
distribution
significant
correlation
(
r
s
=
0.531,
P
1.032
×
10
−4
).
A
difference
found
three
groups
according
TRS.
Conclusion
As
preliminary
problem
clozapine,
Japan,
varies,
are
many
typically
do
consider
possibility
TRS;
this
trend
leads
low
use.
Clearly,
further
clinician
training
needed
appropriate
management
includes
explanation
how
introduce
therapy
their
families.
Clinical
practice
guidelines
for
schizophrenia
and
major
depressive
disorder
have
been
published.
However,
these
not
had
sufficient
penetration
in
clinical
settings.
We
developed
the
Effectiveness
of
Guidelines
Dissemination
Education
Psychiatric
Treatment
(EGUIDE)
project
as
a
dissemination
education
programme
psychiatrists.The
aim
this
study
is
to
assess
effectiveness
EGUIDE
on
subjective
behaviour
psychiatrists
accordance
with
before
1
2
years
after
participation
programmes.A
total
607
participated
during
October
2016
March
2019.
They
attended
both
1-day
educational
programmes
based
disorder,
answered
web
questionnaires
about
their
behaviours
attending
programmes.
evaluated
changes
between
programme.All
scores
were
significantly
improved
compared
There
no
significant
any
attending.All
programme,
maintained
at
least
years.
The
could
contribute
guideline-based
among
psychiatrists.
Psychiatry and Clinical Neurosciences,
Год журнала:
2023,
Номер
77(10), С. 559 - 568
Опубликована: Сен. 8, 2023
This
study
aims
to
examine
the
real-world
effectiveness
of
education
regarding
clinical
guidelines
for
psychiatric
disorders
using
'the
Effectiveness
dissemination
and
in
treatment
(EGUIDE)'
project.
Neuropsychopharmacology Reports,
Год журнала:
2022,
Номер
42(2), С. 221 - 225
Опубликована: Март 10, 2022
Abstract
The
Effectiveness
of
Guidelines
for
Dissemination
and
Education
in
psychiatric
treatment
(EGUIDE)
project,
which
is
a
nationwide
dissemination
implementation
program
clinical
practice
guidelines
(CPGs)
the
field
psychiatry,
currently
ongoing.
In
current
study,
subjective
assessment
participants
EGUIDE
programs
was
assessed
using
questionnaire.
Then,
relationships
between
assessment,
characteristics
participants,
knowledge
CPGs
were
evaluated.
More
than
90%
gave
high
rating
components
content,
recommendation,
knowledge,
skill,
adherence,
but
not
component
confidence.
A
positive
correlation
found
years
professional
experience
score
These
results
suggest
that
it
may
be
necessary
to
apply
skills
obtained
education
into
increase
confidence
proper
use
therapies
based
on
CPGs.
Journal of Neural Transmission,
Год журнала:
2022,
Номер
129(5-6), С. 689 - 701
Опубликована: Март 18, 2022
Abstract
Risperidone
is
commonly
used
to
treat
different
psychiatric
disorders
worldwide.
Knowledge
on
dose–concentration
relationships
of
risperidone
treatment
in
children
and
adolescents
with
schizophrenia
or
other
psychotic
is,
however,
scarce
no
age-specific
therapeutic
ranges
have
been
established
yet.
Multicenter
data
a
drug
monitoring
service
were
analyzed
evaluate
the
relationship
between
dose
serum
concentration
active
moiety
(risperidone
(RIS)
plus
its
main
metabolite
9-hydroxyrisperidone
(9-OH-RIS))
disorders.
Patient
characteristics,
doses,
concentrations
outcomes
assessed
by
standardized
measures.
The
study
also
aimed
whether
reference
range
for
adults
(20–60
ng/ml)
applicable
minors.
In
64
patients
(aged
11–18
years)
included,
positive
correlation
daily
(RIS
am
)
was
found
(
r
s
=
0.49,
p
0.001)
variation
explaining
24%
2
0.240)
variability
concentrations.
While
RIS
showed
difference,
as
well
9-OH-RIS
parent
ratio
varied
significantly
co-medication
CYP2D6
inhibitor.
Patients
extrapyramidal
symptoms
(EPS)
had
average
higher
RISam
than
without
0.05).
Considering
EPS,
upper
threshold
determined
be
33
ng/ml.
A
rough
estimation
method
indicated
possibly
decreased
lower
limit
preliminary
minors
compared
adults.
These
may
contribute
definition
window
schizophrenic
treated
risperidone.
TDM
recommended
this
vulnerable
population
prevent
concentration-related
adverse
reactions.
