Diseases,
Год журнала:
2023,
Номер
11(4), С. 136 - 136
Опубликована: Окт. 5, 2023
Poor
sleep
quality
is
a
major
public
health
concern
for
all
ages.
In
particular,
university
students
often
face
stress
levels
and
changes
in
social
life
habits
that
negatively
influence
their
of
sleep.
This
could
be
associated
with
psychological
well-being
terms
anxiety
depressive
symptoms,
levels,
poor
self-perceived
status.
The
increases
the
pro-inflammatory
cytokine
interleukin
6
(IL-6),
IL-1
beta
(IL-1β),
tumor
necrosis
factor
alpha
(TNFα),
blood
have
been
linked
to
many
diseases,
but
data
on
salivary
are
missing
or
seldom
analyzed.
this
study
we
determined
sample
role
assessment
factors
affecting
(alcohol
intake,
tobacco,
consumption
stimulant
drinks,
exercise,
body
mass
index).
We
also
aimed
shed
new
light
associations
between
inflammatory
cytokines
(IL-1β,
IL-6,
TNFα).
Sleep
was
measured
Athens
Insomnia
Scale
(AIS)
Pittsburgh
Quality
Index
(PSQI).
Perceived
assessed
using
Cohen’s
Stress
(PSS),
Goldberg
Anxiety
Depression
(GADS)
used
assess
level
depression.
status
visual
analogue.
Saliva
samples
taken
morning
via
enzyme-linked
immunoassay.
There
direct
significant
association
IL-1β
concentration
AIS
score
(r
=
0.248;
p
0.038,
Pearson
correlation)
scale
0.274;
0.022,
correlation).
relationship
controlling
sex,
age,
chronic
disease,
still
0.260;
0.033).
PSQI
these
variables
0.279;
0.022).
Salivary
concentrations
were
not
significantly
any
scores
other
assessments
(PSS,
anxiety,
depression
health).
TNFα
inversely
−0.259;
0.033,
correlation),
IL-6
scores.
Our
results
provide
novel
saliva
quality.
However,
inflammation
requires
further
identify
strategies
lower
thus,
likely
improve
Journal of Alzheimer s Disease,
Год журнала:
2023,
Номер
93(3), С. 1033 - 1040
Опубликована: Май 16, 2023
There
is
emerging
evidence
that
coronavirus
disease
2019
(COVID-19)
giving
rise
to
seemingly
unrelated
clinical
conditions
long
after
the
infection
has
resolved.The
aim
of
this
study
examine
whether
COVID-19
associated
with
an
increased
risk
dementia
including
Alzheimer's
disease.This
retrospective
cohort
based
on
longitudinal
data
from
IQVIATM
Disease
Analyzer
database
and
included
patients
aged≥65
initial
diagnosis
or
acute
upper
respiratory
(AURI)
1,293
general
practitioner
practices
between
January
2020
November
2021.
AURI
were
matched
1
:
using
propensity
scores
sex,
age,
index
quarter,
health
insurance
type,
number
doctor
visits,
comorbidities
risk.
Incidence
rates
newly-diagnosed
calculated
person-years
method.
Poisson
regression
models
used
compute
incidence
rate
ratios
(IRR).The
present
8,129
pairs
(mean
age
75.1
years,
58.9%
females).
After
12
months
follow-up,
1.84%
1.78%
had
been
diagnosed
dementia.
The
model
resulted
in
IRR
1.05
(95%
CI:
0.85-1.29).This
did
not
find
any
association
one-year
controlling
for
all
common
factors
Because
a
progressive
disease,
which
can
be
difficult
diagnose,
longer
follow-up
period
might
offer
better
insight
into
possible
cases
future.
European Psychiatry,
Год журнала:
2024,
Номер
67(1)
Опубликована: Янв. 1, 2024
Abstract
Background
There
is
considerable
evidence
of
cognitive
impairment
post
COVID-19,
especially
in
individuals
with
long-COVID
symptoms,
but
limited
research
objectively
evaluating
whether
such
attenuates
or
resolves
over
time,
young
and
middle-aged
adults.
Methods
Follow-up
assessments
(T2)
function
(processing
speed,
attention,
working
memory,
executive
function,
memory)
mental
health
were
conducted
138
adults
(18–69
years)
who
had
been
assessed
6
months
earlier
(T1).
Of
these,
88
a
confirmed
history
COVID-19
at
T1
assessment
(≥20
days
post-diagnosis)
also
followed-up
on
COVID-19-related
symptoms
(acute
long-COVID);
50
no
known
any
point
up
to
their
T2
assessment.
Results
From
T2,
trend-level
improvement
occurred
intra-individual
variability
processing
speed
the
COVID,
relative
non-COVID
group.
However,
longer
response/task
completion
times
persisted
participants
hospitalisation
those
without
controls.
was
significant
reduction
symptom
load,
which
correlated
improved
non-hospitalised
participants.
The
COVID
group
continued
self-report
poorer
health,
irrespective
history,
Conclusions
Although
some
has
6-month
period
survivors,
persists
and/or
symptoms.
Continuous
follow-up
are
required
determine
improves
possibly
worsens,
time
hospitalised
Acta Neuropsychiatrica,
Год журнала:
2024,
Номер
36(4), С. 211 - 217
Опубликована: Апрель 12, 2024
Individuals
who
have
recovered
from
the
acute
stage
of
SARS-CoV-2
infection
may
be
at
risk
developing
post-COVID-19
condition
(PCC),
characterised
by
a
spectrum
persisting,
non-specific,
and
functionally
impairing
symptoms
across
multiple
organ
systems.
Obesity
has
been
implicated
as
factor
for
PCC,
mediated
chronic
systemic
inflammation.
The
foregoing
also
separately
reported
to
mediate
cognitive
dysfunction
in
PCC.
Abstract
Caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2),
disease
2019
(COVID‐19)
primarily
manifests
as
dysfunction.
However,
emerging
evidence
suggests
SARS‐CoV‐2
can
invade
the
brain,
leading
to
cognitive
impairment
(CI).
It
may
spread
other
brain
regions
through
transsynaptic
neurons,
including
olfactory,
optic,
and
vagus
nerves.
Moreover,
it
central
nervous
system
blood
transmission
or
lymphatic
system.
This
review
summarizes
neuroimaging
from
clinical
imaging
studies
of
COVID‐19‐associated
CIs,
magnetic
resonance
18F‐fluorodeoxyglucose
positron
emission
tomography‐computed
tomography.
The
mechanisms
underlying
CIs
are
currently
being
actively
investigated.
They
include
nonimmune
effects,
such
viral
proteins,
tissue
hypoxia,
hypercoagulability,
pathological
changes
in
neuronal
cells,
immune
microglia
astrocyte
activation,
peripheral
cell
infiltration,
blood‐brain
barrier
impairment,
cytokine
network
dysregulation,
intestinal
microbiota.
Inflammation
is
feature.
Both
systemic
inflammation
cause
persistent
neurological
changes,
existing
indicates
that
underlies
elevated
risk
Alzheimer's
disease.
Finally,
potential
therapeutic
options
for
discussed.
In‐depth
research
into
still
needed
help
develop
new
therapies.
Diseases,
Год журнала:
2023,
Номер
11(4), С. 136 - 136
Опубликована: Окт. 5, 2023
Poor
sleep
quality
is
a
major
public
health
concern
for
all
ages.
In
particular,
university
students
often
face
stress
levels
and
changes
in
social
life
habits
that
negatively
influence
their
of
sleep.
This
could
be
associated
with
psychological
well-being
terms
anxiety
depressive
symptoms,
levels,
poor
self-perceived
status.
The
increases
the
pro-inflammatory
cytokine
interleukin
6
(IL-6),
IL-1
beta
(IL-1β),
tumor
necrosis
factor
alpha
(TNFα),
blood
have
been
linked
to
many
diseases,
but
data
on
salivary
are
missing
or
seldom
analyzed.
this
study
we
determined
sample
role
assessment
factors
affecting
(alcohol
intake,
tobacco,
consumption
stimulant
drinks,
exercise,
body
mass
index).
We
also
aimed
shed
new
light
associations
between
inflammatory
cytokines
(IL-1β,
IL-6,
TNFα).
Sleep
was
measured
Athens
Insomnia
Scale
(AIS)
Pittsburgh
Quality
Index
(PSQI).
Perceived
assessed
using
Cohen’s
Stress
(PSS),
Goldberg
Anxiety
Depression
(GADS)
used
assess
level
depression.
status
visual
analogue.
Saliva
samples
taken
morning
via
enzyme-linked
immunoassay.
There
direct
significant
association
IL-1β
concentration
AIS
score
(r
=
0.248;
p
0.038,
Pearson
correlation)
scale
0.274;
0.022,
correlation).
relationship
controlling
sex,
age,
chronic
disease,
still
0.260;
0.033).
PSQI
these
variables
0.279;
0.022).
Salivary
concentrations
were
not
significantly
any
scores
other
assessments
(PSS,
anxiety,
depression
health).
TNFα
inversely
−0.259;
0.033,
correlation),
IL-6
scores.
Our
results
provide
novel
saliva
quality.
However,
inflammation
requires
further
identify
strategies
lower
thus,
likely
improve
