
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Май 8, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Май 8, 2024
Язык: Английский
Brain Behavior and Immunity, Год журнала: 2024, Номер 122, С. 75 - 94
Опубликована: Авг. 9, 2024
Язык: Английский
Процитировано
7medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Окт. 5, 2023
Abstract Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α+β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. Methods IgA / IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. Results is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7% variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r=0.801. Conclusion Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.
Язык: Английский
Процитировано
12Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Апрель 22, 2024
Abstract Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, aim of this study was to assess selected nitrosative parameters glycoxidation products in COVID-19 patients convalescents relative healthy subjects, including reference severity symptoms. The diagnostic utility biomarkers also evaluated patients. involved 218 COVID-19, 69 convalescents, 48 subjects. (NO, S-nitrosothiols, nitrotyrosine) (tryptophan, kynurenine, N-formylkynurenine, dityrosine, AGEs) were measured blood plasma or serum use colorimetric/fluorometric methods. levels NO ( p = 0.0480), S-nitrosothiols 0.0004), nitrotyrosine 0.0175), kynurenine < 0.0001), N-formylkynurenine dityrosine AGEs 0.0001) significantly higher, whereas tryptophan fluorescence lower than control group. Significant differences analyzed observed different stages COVID-19. In turn, concentrations controls. ROC analysis revealed that be useful for diagnosing infections virus because they differentiate (KN: sensitivity—91.20%, specificity—92.00%; NFK: sensitivity—92.37%, AGEs: sensitivity—99,02%, specificity—100%) sensitivity—82.22%, specificity—84.00%; sensitivity—82,86%, specificity—86,00%; DT: sensitivity—100%, specificity—100%; AGE: from subjects high sensitivity specificity. are intensified after redox fluctuate disease. Circulating stress/protein have potential convalescents.
Язык: Английский
Процитировано
4Journal of Medical Virology, Год журнала: 2024, Номер 96(8)
Опубликована: Авг. 1, 2024
Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, its affective chronic fatigue syndrome symptoms, labeled "the physio-affective phenome." To investigate whether COVID phenome are linked autoimmunity tight junction proteins, zonulin occludin (ZOOC), immune reactivity lipopolysaccharides (LPS), latter associated with signs human herpes virus-6 (HHV-6) reactivation, directed against oligodendrocyte neuronal including myelin basic protein. IgA/IgM/IgG severe acute respiratory coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, C-reactive protein (CRP), advanced oxidation products (AOPPs), were measured in 90 patients healthy controls. The was conceptualized as a factor extracted from physical symptom domains. Neural network identified IgA LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, IgA-ZOOC important variables diagnosis an area under ROC curve 0.755. Partial Least Squares analysis showed that 40.9% variance explained by CRP, IgA-myelin (MBP), IgG-MBP. A large part variances both MBP (36.3%-39.7%) (IgA IgG) ZOOC. strongly indicants HHV-6 which turn increased IgM-SARS-CoV-2. Autoimmunity components junctions bacterial translocation may be involved COVID's phenome.
Язык: Английский
Процитировано
4Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
3medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Фев. 8, 2024
Abstract Background Multiple studies have shown that Long COVID (LC) disease is associated with heightened immune activation, as evidenced by elevated levels of inflammatory mediators. However, there no comprehensive meta-analysis focusing on activation the response system (IRS) and compensatory immunoregulatory (CIRS) along other phenotypes in LC patients. Objectives This designed to explore IRS CIRS profiles patients, individual cytokines, chemokines, growth factors, C-reactive protein (CRP) immune-associated neurotoxicity. Methods To gather relevant for our research, we conducted a thorough search using databases such PubMed, Google Scholar, SciFinder, covering all available literature up December 20th, 2023. Results The current encompassed 82 examined multiple profiles, protein, 58 cytokines/chemokines/growth factors 3836 patients versus 4537 normal controls (NC). showed significant increases IRS/CIRS ratio (standardized mean difference (SMD:0.156, confidence interval (CI): 0.051;0.261), (SMD: 0.345, CI: 0.222;0.468), M1 macrophage 0.421, 0.290;0.551), T helper (Th)1 0.353, 0.189;0.517), Th17 0.492, 0.332;0.651) neurotoxicity 0.327 0.205;0.448). In addition, CRP 19 different cytokines displayed significantly compared NC. Conclusion characterized increased
Язык: Английский
Процитировано
1bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 14, 2024
Summary Cognitive deficits from dorsolateral prefrontal cortex (dlPFC) dysfunction are common in neuroinflammatory disorders, including long-COVID, schizophrenia and Alzheimer’s disease, have been correlated with kynurenine inflammatory signaling. Kynurenine is further metabolized to kynurenic acid (KYNA) brain, where it blocks NMDA α7-nicotinic receptors (nic-α7Rs). These essential for neurotransmission dlPFC, suggesting that KYNA may cause higher cognitive these disorders. The current study found its synthetic enzyme, KAT II, greatly expanded expression primate dlPFC both glia neurons. Local application of onto neurons markedly reduced the delay-related firing needed working memory via actions at nic-α7Rs, while inhibition II enhanced neuronal aged macaques. Systemic administration agents reduce production similarly improved performance monkeys, a therapeutic avenue treatment
Язык: Английский
Процитировано
1Journal of Advanced Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α + β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. IgA/IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7 % variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r = 0.801. Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.
Язык: Английский
Процитировано
1Опубликована: Май 1, 2024
Abstract Background Recent studies confirm the involvement of activated immune-inflammatory responses and increased oxidative nitrosative stress in Long COVID (LC) disease. However, influence these pathways on metabolism tryptophan (TRP) through TRP catabolite (TRYCAT) pathway their mediating effects LC pathophysiology, has not been fully explored. Objective This meta-analysis investigates peripheral TRYCAT levels patients with Method review utilized systematic searches PubMed, Google Scholar, SciFinder, including 14 full-text articles 1,167 participants, consisting 480 687 normal controls. Results The results indicated a significant increase kynurenine (KYN)/TRP ratio, large effect size (standardized mean difference, SMD = 0.755; confidence intervals, CI: 0.119;1.392), compared to Additionally, exhibited decrease (SMD -0.520, -0.793; -0.246) an KYN after imputing missing 1.176, 0.474; 1.877), suggesting activation Indoleamine 2,3-dioxygenase (IDO) enzyme upregulation pathway. No elevation TRYCAT-related neurotoxicity, kynurenic acid (KA)/KYN 3-hydroxykynurenine (3-HK)/KYN ratios were observed Conclusion current findings indicate that pathway, characterized by decreased maybe elevated levels, plays role pathophysiology LC.
Язык: Английский
Процитировано
0medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 30, 2024
Abstract Background Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, its affective chronic fatigue syndrome (CFS) symptoms, labeled “the physio-affective phenome.” Objectives To investigate whether COVID phenome are linked autoimmunity tight junction proteins, zonulin occludin (ZOOC), immune reactivity lipopolysaccharides (LPS), latter associated with signs human herpes virus-6 reactivation (HHV-6), directed against oligodendrocyte neuronal including myelin basic protein (MBP). Methods IgA / IgM/IgG Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, C-reactive (CRP) advanced oxidation products (AOPP), were measured in 90 patients healthy controls. The was conceptualized as a factor extracted from physical symptom domains. Results Neural network identified LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, IgA-ZOOC most important variables diagnosis an area under ROC curve 0.755. Partial Least Squares analysis showed that 40.9% variance explained by CRP, IgA-MPB IgG-MBP. A large part variances both MBP (36.3-39.7%) (IgA IgG) ZOOC. strongly indicants HHV-6 reactivation, which turn increased IgM-SARS-CoV-2. Conclusions Autoimmunity components junctions bacterial translocation may be involved COVID’s phenome.
Язык: Английский
Процитировано
0