Experimental Eye Research, Год журнала: 2022, Номер 219, С. 109035 - 109035
Опубликована: Март 17, 2022
Язык: Английский
Journal of Immunology Research, Год журнала: 2022, Номер 2022, С. 1 - 12
Опубликована: Март 23, 2022
Oxidative stress plays an important role in the development of aging-related diseases by accelerating lipid peroxidation polyunsaturated fatty acids cell membrane, resulting production aldehydes, such as malondialdehyde and 4-hydroxy-2-nonenal (4-HNE) other toxic substances. The compound 4-HNE forms adducts with DNA or proteins, disrupting many signaling pathways including regulation apoptosis signal transduction pathways. binding proteins to (4-HNE-protein) acts marker peroxidation, its increasing concentration brain tissues fluids because aging, ultimately gives rise some hallmark disorders, neurodegenerative (Alzheimer’s Parkinson’s diseases), ophthalmic (dry eye, macular degeneration), hearing loss, cancer. This review aims describe physiological origin 4-HNE, elucidate toxicity diseases, discuss detoxifying effect aldehyde dehydrogenase glutathione 4-HNE-driven diseases.
Язык: Английский
Процитировано
128
Pathology & Oncology Research, Год журнала: 2024, Номер 30
Опубликована: Фев. 23, 2024
Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel intricate relationship between process pathogenesis age-related diseases. This paper explores pivotal role played by geroscience in reshaping our understanding pathology, with particular focus on These diseases, spanning cardiovascular cerebrovascular disorders, malignancies, neurodegenerative conditions, significantly contribute morbidity mortality older individuals. We delve into fundamental cellular molecular mechanisms underpinning aging, including mitochondrial dysfunction senescence, elucidate their profound implications for various Emphasis is placed importance assessing key biomarkers biological age within realm pathology. also scrutinize interplay senescence cancer biology as central area focus, underscoring its paramount significance contemporary pathological research. Moreover, we shed light integration anti-aging interventions that target processes, such senolytics, mitochondria-targeted treatments, influence epigenetic regulation domain pathology In conclusion, concepts research heralds transformative paradigm shift disease promises breakthroughs prevention treatment.
Язык: Английский
Процитировано
28
Antioxidants, Год журнала: 2024, Номер 13(4), С. 422 - 422
Опубликована: Март 29, 2024
Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It characterized by loss of tear film homeostasis and accompanied symptoms that may potentially result in damage to surface even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, ethanol consumption. As its prevalence continues rise, has garnered considerable attention, prompting exploration potential new therapeutic targets. Recent studies have found when production ROS exceeds capacity antioxidant defense system on surface, oxidative stress ensues, leading cellular apoptosis further damage. These events can exacerbate inflammation responses, increasing levels promoting vicious cycle DED. Therefore, given central role reactive oxygen species DED, strategies involving antioxidants emerged novel approach treatment. This review aims enhance our understanding intricate relationship between thereby providing directions explore innovative approaches this complex disorder.
Язык: Английский
Процитировано
22
ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 884 - 890
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
2
Antioxidants, Год журнала: 2021, Номер 10(12), С. 1929 - 1929
Опубликована: Ноя. 30, 2021
Aging is inevitable, but the inherently and genetically programmed aging process markedly influenced by environmental factors. All organisms are constantly exposed to various stresses, either exogenous or endogenous, throughout their lives, quality quantity of stresses generate diverse impacts on organismal process. In current oxygenic atmosphere earth, oxidative stress caused reactive oxygen species one most common critical factors for life. The Kelch-like ECH-associated protein 1-NFE2-related factor 2 (KEAP1-NRF2) system a defense mechanism cells in response redox perturbations. presence electrophilic insults, thiol moieties cysteine KEAP1 modified, consequently NRF2 activates its target genes detoxification cytoprotection. A number studies have clarified contributions KEAP1-NRF2 prevention attenuation physiological aging-related diseases. Accumulating knowledge control stress-induced damage may provide clue extending healthspan treating this review, we focus relationships between alterations sensory, glandular, muscular, central nervous systems roles processes.
Язык: Английский
Процитировано
69
The Ocular Surface, Год журнала: 2022, Номер 25, С. 108 - 118
Опубликована: Июнь 23, 2022
Язык: Английский
Процитировано
52
All Life, Год журнала: 2024, Номер 17(1)
Опубликована: Фев. 21, 2024
'Oxidative stress' (OS) refers to the deviations in redox biology inside biological systems. This term has been used illustrate imbalance between oxidants and antioxidants, which a subject of extensive research. The obtained findings suggest that many diseases are linked OS, including diabetes mellitusinflammation, cancers, autoimmune disorders neurodegenerative diseases. More recently, significant advances biochemistry molecular have enabled researchers find master switches various OS mechanisms associate development paradigms. In this review, brief overview research is provided offer insight into its future directions. Most importantly, need for greater understanding vital role progression emphasized. Likewise, more work needed on utility reactive oxygen species markers as diagnostic tool.
Язык: Английский
Процитировано
10
Small Structures, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 11, 2024
Topical instillation of cyclosporin A (an anti‐inflammatory drug) is clinically recommended as the first‐line treatment for dry eye disease. Nevertheless, it suffers from poor ocular drug retention and cannot comprehensively address corneal dryness‐related symptoms such oxidative stress, angiogenesis, neurodegeneration. Inspired by nanotechnology‐mediated material/biological interactions, in this study, a highly adhesive metallic nanoplatform with an urchin‐like structure designed topical quercetin administration therapy. The gold nanostructures most pronounced branch lengths exhibit strongest cytoadhesion bioadhesion capabilities, which significantly enhance nano‐urchins 150‐fold at 7 days post‐instillation compared smooth‐surfaced nanoparticles. In rabbit model dryness, single‐dose nanoformulation (high quercetin‐functionalized (NU‐Q(H))) demonstrated remarkable efficacy stimulating tear production (30‐fold improvement), inhibiting inflammatory IL‐6 expression (49‐fold attenuating pathological angiogenesis (32‐fold promoting nerve regeneration (18‐fold improvement) to high nanoparticles (NP‐Q(H)). particular, integrity surface, film, meibomian gland restored levels similar those healthy rabbits. These findings suggest promising potential nanobiomaterial structural engineering developing nanomedicines long‐acting eye‐drop formulations disease applications.
Язык: Английский
Процитировано
8
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 10
Опубликована: Янв. 4, 2023
Lacrimal gland plays a vital role in maintaining the health and function of ocular surface. Dysfunction leads to disruption surface homeostasis can lead severe outcomes. Approaches evolving through regenerative medicine have recently gained importance restore gland. Using human induced pluripotent stem cells (iPSCs), we generated functional vitro lacrimal organoids by adopting multi zonal differentiation approach. We differentiated iPSCs confirmed commitment neuro ectodermal lineage. Then identified emergence mesenchymal epithelial progenitor third week differentiation. Differentiated progenitors underwent branching morphogenesis following weeks, typical development. were able confirm presence specific acinar, ductal, myoepithelial structures during weeks 4-7. Further on, demonstrated miR-205 regulation organoid development monitoring FGF10 mRNA levels throughout process. In addition, assessed functionality using β-Hexosaminidase assay, confirming secretory organoids. Finally, metabolomics analysis revealed shift from amino acid metabolism lipid These functional, tear proteins secreting harbor great potential for improvement existing treatment options dysfunction serve as platform study morphogenesis.
Язык: Английский
Процитировано
14
Clinical Immunology, Год журнала: 2023, Номер 248, С. 109251 - 109251
Опубликована: Фев. 3, 2023
Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates suggest ectopic structures. However, these structures have not been fully investigated. Using mice of different ages, we analyzed the transcriptome murine LGs and characterized B T cell populations. Age-related changes LG include differentially expressed genes associated with activation, germinal center formation, infiltration by marginal zone-like cells. also identified an age-related increase B1
Язык: Английский
Процитировано
13