Stimulus-Responsive Hydrogels for Targeted Cancer Therapy
Gels,
Год журнала:
2024,
Номер
10(7), С. 440 - 440
Опубликована: Июль 1, 2024
Cancer
is
a
highly
heterogeneous
disease
and
remains
global
health
challenge
affecting
millions
of
human
lives
worldwide.
Despite
advancements
in
conventional
treatments
like
surgery,
chemotherapy,
immunotherapy,
the
rise
multidrug
resistance,
tumor
recurrence,
their
severe
side
effects
complex
nature
microenvironment
(TME)
necessitates
innovative
therapeutic
approaches.
Recently,
stimulus-responsive
nanomedicines
designed
to
target
TME
characteristics
(e.g.,
pH
alterations,
redox
conditions,
enzyme
secretion)
have
gained
attention
for
potential
enhance
anticancer
efficacy
while
minimizing
adverse
chemotherapeutics/bioactive
compounds.
Among
various
nanocarriers,
hydrogels
are
intriguing
due
high-water
content,
adjustable
mechanical
characteristics,
responsiveness
external
internal
stimuli,
making
them
promising
candidates
cancer
therapy.
These
properties
make
an
ideal
nanocarrier
controlled
drug
release
within
TME.
This
review
comprehensively
surveys
latest
area
therapy,
exploring
stimuli-responsive
mechanisms,
including
biological
pH,
redox),
chemical
enzymes,
glucose),
physical
temperature,
light),
as
well
dual-
or
multi-stimuli
responsiveness.
Furthermore,
this
addresses
current
developments
challenges
treatment.
Our
aim
provide
readers
with
comprehensive
understanding
treatment,
offering
novel
perspectives
on
development
therapy
other
medical
applications.
Язык: Английский
“Monitor-and-treat” that integrates bacterio-therapeutics and bio-optics for infected wound management
Bioactive Materials,
Год журнала:
2025,
Номер
48, С. 118 - 134
Опубликована: Фев. 15, 2025
Язык: Английский
Stimulus-responsive hydrogels for targeted cancer therapy
Опубликована: Июнь 14, 2024
Cancer
is
a
highly
heterogeneous
disease
and
remains
global
health
challenge
affecting
millions
of
human
lives
worldwide.
Despite
advancements
in
conventional
treatments
like
surgery,
chemotherapy,
immunotherapy,
the
rise
multidrug
resistance,
tumor
recurrence,
severe
side
effects
necessitates
innovative
therapeutic
approaches.
The
complex
nature
microenvironment
(TME)
further
compromises
efficacy
traditional
chemotherapy
drugs.
Recently,
stimulus-responsive
nanomedicines
designed
to
target
TME
characteristics
(e.g.,
pH,
redox,
enzymes)
have
gained
attention
for
their
potential
enhance
anticancer
while
minimizing
adverse
effects.
Among
various
nanocarriers,
hydrogels
are
an
interesting
class
nanocarriers
used
cancer
therapy
due
high
water
content,
adjustable
mechanical
characteristics,
ability
respond
external/internal
stimuli.
These
properties
make
ideal
nanocarrier
controlled
drug
release
within
TME.
This
review
comprehensively
surveys
latest
therapy,
exploring
stimuli-responsive
mechanisms,
including
biological
redox),
chemical
enzymes,
glucose),
physical
temperature,
light),
as
well
dual-
or
multi-stimuli
responsiveness.
will
offer
novel
perspectives
on
development
therapy.
Язык: Английский
Controlled Delivery of MTX from Thermosensitive Hydrogels Using Au Nanorods for Enhanced Therapeutics of Psoriasis via Improving Stratum Corneum Penetration
Hao Chen,
Jiangmei Xu,
Yongxin Jiang
и другие.
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Topical
transdermal
drug
delivery
for
psoriasis
remains
a
challenge
because
of
the
poor
solubility
hydrophobic
drugs
and
limited
penetration
stratum
corneum.
In
this
study,
near-infrared
(NIR)
light-responsive
thermosensitive
hydrogel
(PDLLA-PEG-PDLLA,
PLEL)-based
reservoir
is
developed
that
directly
incorporated
gold
nanorods
(GNRs)
methotrexate
(MTX)
in
sol
state
at
low
temperature,
which
referred
to
as
PLEL@GNR+MTX.
The
vitro
anti-psoriasis
experiment
indicated
that,
GNRs,
photothermal
cores
composite
hydrogel,
not
only
triggered
keratinocyte
apoptosis
but
also
promoted
MTX
release
synergistic
manner.
Moreover,
rapid
phase
transition
enhanced
formulation
through
corneum
upon
NIR
light
irradiation
prolonged
skin
retention
after
returning
gel
mouse
model.
Compared
with
commercial
ointment
treatments,
PLEL@GNR+MTX
have
similar
efficacy
psoriatic
lesion
resolution
without
wrinkling.
prepared
featured
excellent
biocompatibility
accumulation
GNRs
healthy
organs
tissues
negligible.
Overall,
light-activatable
hydrogel-based
platform
can
utilize
"trigger
switch"
more
precisely,
improve
bioavailability,
facilitate
permeation
across
barrier
during
reversible
phase-change
processes.
Язык: Английский
Preparation of reversible temperature sensitive acrylamide terpolymer hydrogel for cascade drug loadings
Journal of Macromolecular Science Part A,
Год журнала:
2025,
Номер
62(2), С. 187 - 199
Опубликована: Янв. 20, 2025
As
a
drug
delivery
system
with
vast
potential
applications,
hydrogels
have
garnered
significant
attention
due
to
their
unique
loading
mechanisms
and
effectiveness.
In
this
paper,
novel
reversible
thermosensitive
hydrogel
polymer,
synthesized
through
copolymerization
of
mono-6-allyl-β-cyclodextrin,
N-isopropylacrylamide,
acrylamide,
is
introduced.
This
polymer
formed
three-dimensional
network
structure
in
water,
featuring
β-cyclodextrin
hydrophobic
cavities.
The
encapsulated
molecules
could
be
slowly
progressively
released
from
both
the
IR
XRD
analysis
confirmed
successful
encapsulation
target
molecules,
sodium
salicylate
naproxen
sodium,
within
cavity
its
space.
Specifically,
when
mass
ratio
N-isopropylacrylamide/acrylamide/mono-6-allyl-β-cyclodextrin
was
9.8/0.2/0.5,
demonstrated
an
initial
gelation
temperature
34.9
°C
final
37
°C.
expansion
rate
blank
slightly
higher
than
that
drug-loaded
hydrogel.
Both
drugs
undergo
sustained
release
hydrogel,
adhering
Fick's
diffusion
law,
ensuring
consistent
8
h
maintaining
for
over
24
h,
regardless
rate.
Within
30
days,
degradation
PBS
exceeded
15%,
while
presence
lysozyme
more
40%.
These
properties
render
versatile
candidate
targeted
biomedical
offering
strategies
treating
chronic
diseases
other
conditions.
Язык: Английский
Injectable, self-healing and antioxidative gelatin-based nanocomposite hydrogels accelerating full-thickness wound healing
European Polymer Journal,
Год журнала:
2025,
Номер
unknown, С. 113901 - 113901
Опубликована: Март 1, 2025
Язык: Английский
Hydrogel-based 3D printing technology: From interfacial engineering to precision medicine
Advances in Colloid and Interface Science,
Год журнала:
2025,
Номер
341, С. 103481 - 103481
Опубликована: Март 19, 2025
Язык: Английский
Emerging Applications of Smart Hydrogel Nanocomposites in 3D Printing
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(12)
Опубликована: Дек. 1, 2024
ABSTRACT
This
review
provides
a
comprehensive
overview
of
the
emerging
applications
stimuli‐responsive
hydrogels
in
3D
printing,
emphasizing
their
transformative
potential
creating
adaptive
and
multifunctional
structures.
Stimuli‐responsive
hydrogels,
including
magneto‐,
thermo‐,
pH‐,
moisture‐,
solvent‐,
photo‐responsive
varieties,
have
gained
significant
attention
due
to
ability
undergo
dynamic
changes
response
specific
environmental
stimuli.
The
begins
by
exploring
fundamental
characteristics
fabrication
methods
used
additive
manufacturing,
highlighting
exceptional
adaptability
programmability.
It
then
delves
into
various
across
diverse
fields,
soft
robotics,
tissue
engineering,
drug
delivery
systems,
wearable
electronics,
food
technology,
electromagnetic
interference
shielding,
anti‐counterfeiting
technologies.
By
integrating
latest
advancements
printing
techniques,
this
aims
offer
insights
how
are
enabling
development
innovative,
intelligent,
environmentally
responsive
systems.
future
perspectives
section
discusses
challenges
opportunities
for
advancing
use
suggesting
directions
research
that
could
push
boundaries
functional
materials
programmable
Язык: Английский
Cancer treatment approaches within the frame of hyperthermia, drug delivery systems, and biosensors: concepts and future potentials
RSC Advances,
Год журнала:
2024,
Номер
14(53), С. 39297 - 39324
Опубликована: Янв. 1, 2024
This
work
presents
a
review
of
the
therapeutic
modalities
and
approaches
for
cancer
treatment.
Язык: Английский
A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100282 - 100282
Опубликована: Авг. 30, 2024
Bone
metastasis
remains
a
clinical
challenge
and
is
still
considered
incurable.
While
nanoparticles-based
drug
delivery
photothermal
therapy
(PTT)
show
promise
in
treating
subcutaneous
solid
tumor,
their
therapeutic
outcome
bone
limited,
due
to
the
inaccessibility
of
metastatic
site
complexity
metastasis.
Herein,
we
reported
simple
nanoplatform
composed
thermo-sensitive
liposomes
(TSL)
gold
nanorods
(GNR)
treat
through
improved
chemotherapy
combined
with
GNR-assisted
PTT.
Lipid
combination
TSL
was
firstly
tailored
regulate
its
stability
under
physiological
condition
as
well
sensitivity
responding
PTT-caused
mild
hyperthermia.
The
obtained
loaded
then
GNR
form
unsophisticated
incubation.
Cell
experiments
revealed
that
upon
near-infrared
(NIR)
irradiation,
effectively
inhibited
viability
migration
ability
tumor
cells
PTT,
PTT-triggered
release,
PTT-augmented
drug.
In
murine
model
metastasis,
enabled
effective
for
rapid
release
local
NIR
irradiation.
Through
killing
rebalancing
turnover
osteoclasts
osteoblasts,
largely
preserved
structure
pain
relief
survival
extension.
Inspired
by
simplicity
acquirement
treatment
operation,
strategy
liposomes-based
PTT
greatly
promising
Язык: Английский