pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 226 - 226

Опубликована: Фев. 10, 2025

Inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) or Crohn's disease, are becoming a growing global problem due to the limitations of current treatments, which fail address needs patients effectively. UC is characterized by widespread inflammation mucosal lining, affecting both rectum and entire length colon. Over past forty years, traditional treatments for IBDs have primarily relied on anti-inflammatory drugs immunosuppressive medications. Treatment could be more effective if specifically targeted act directly Conventional drug delivery systems encounter numerous challenges their way colon, physiological barriers disease severity. To these issues, pH-dependent carriers emerged promising advancement, offering tolerable treatment UC. These enable localized, action, reducing side effects preventing premature clearance from inflamed colon tissues. pH-responsive leading approach release in they take advantage varying pH levels throughout gastrointestinal tract (GIT). By incorporating pH-sensitive polymers, ensure protection controlled lower GIT. This review will discuss advantages colon-targeted delivery.

Язык: Английский

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Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Язык: Английский

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Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial applications

Journal of Materials Science Materials in Medicine, Год журнала: 2025, Номер 36(1)

Опубликована: Март 5, 2025

Oral drug administration is the preferred route for pharmaceuticals, accounting ~90% of global pharmaceutical market due to its convenience and cost-effectiveness. This study provides a comprehensive scientific technological analysis latest advances in oral dosage forms colon-targeted delivery. Utilizing patent databases, along with bibliometric bibliographical review, we compared (technology) specific application technology (colon delivery) using four search equations. Our findings reveal gap publications inventions associated colon release general applications. While tablets capsules were found most used forms, other platforms such as nanoparticles, microparticles, emulsions have been also explored. Enteric coatings are frequently applied excipient prevent early stomach pH-triggered systems being predominant mechanism. In summary, this review last advancements high-impact resources development delivery, providing insights into maturity these approaches.

Язык: Английский

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Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H2S/ROS in managing inflammatory bowel disease

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123501 - 123501

Опубликована: Март 1, 2025

Язык: Английский

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Improving the prebiotic activity and oxidative stability of carboxymethyl curdlan − quercetin conjugates stabilized Pickering emulsions for the colonic targeting delivery of curcumin

Food Research International, Год журнала: 2024, Номер 201, С. 115641 - 115641

Опубликована: Дек. 30, 2024

Язык: Английский

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