Systemic determinants of brain health in ageing
Nature Reviews Neurology,
Год журнала:
2024,
Номер
20(11), С. 647 - 659
Опубликована: Окт. 7, 2024
Язык: Английский
Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study
Alzheimer s Research & Therapy,
Год журнала:
2025,
Номер
17(1)
Опубликована: Янв. 16, 2025
Many
risk
factors
for
dementia
have
been
identified,
but
the
timing
of
is
less
well
understood.
Here,
we
analyzed
in
a
case-control
study
covering
10
years
before
an
incident
diagnosis.
We
designed
using
insurance
claims
outpatient
consultations
patients
with
German
statutory
health
between
January
1,
2012,
and
December
31,
2022.
included
diagnosis
controls
without
matched
1:2
age,
sex,
region,
earliest
year
encounter.
selected
exposures
based
on
previous
systematic
reviews,
cohort
studies
reporting
factors,
comorbidities,
prodromal
features
dementia.
calculated
prevalence
cases
odds
ratios
each
index
date,
along
Bonferroni-corrected
confidence
intervals,
conditional
logistic
regression.
identified
total
1,686,759
(mean
(SD)
82.15
(6.90)
years;
61.70%
female)
3,373,518
female).
Study
participants
were
followed
up
mean
6.6
(2.3)
years.
Of
63
examined,
56
associated
increased
all
during
10th
1st
date.
These
established
such
as
depression,
hypertension,
hearing
impairment,
nicotine
alcohol
abuse,
obesity,
hypercholesterolaemia,
traumatic
brain
injury,
diabetes.
The
greatest
risk,
greater
than
2.5,
was
conferred
by
delirium,
memory
mental
retardation,
personality
behavioral
disorders,
sensory
schizophrenia,
psychosis.
Cancer
reduced
This
large
confirmed
In
addition,
non-specific
diagnoses
that
showed
steep
increase
close
to
psychosis,
conduct
disorder,
other
disorders.
Consideration
these
diagnoses,
which
may
represent
rather
dementia,
help
identify
people
routine
care.
Язык: Английский
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis
Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
unknown, С. 108831 - 108831
Опубликована: Фев. 1, 2025
Язык: Английский
Risk of dementia in different types of cancer survivors: A nationwide cohort study
American Journal of Geriatric Psychiatry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Язык: Английский
Gut-Brain Nexus: Mapping Multi-Modal Links to Neurodegeneration at Biobank Scale
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Abstract
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD)
are
influenced
by
genetic
environmental
factors.
Using
data
from
UK
Biobank,
SAIL
FinnGen,
we
conducted
an
unbiased,
population-scale
study
to:
1)
Investigate
how
155
endocrine,
nutritional,
metabolic,
digestive
system
disorders
associated
with
AD
PD
risk
prior
to
their
diagnosis,
considering
known
influences;
2)
Assess
plasma
biomarkers’
specificity
for
or
in
individuals
these
conditions;
3)
Develop
a
multi-modal
classification
model
integrating
genetics,
proteomics,
clinical
relevant
conditions
affecting
the
gut-brain
axis.
Our
findings
show
that
certain
elevate
before
diagnosis
including:
insulin
non-insulin
dependent
diabetes
mellitus,
noninfective
gastro-enteritis
colitis,
functional
intestinal
disorders,
bacterial
infections,
among
others.
Polygenic
scores
revealed
lower
predisposition
co-occurring
categories,
underscoring
importance
of
regulating
axis
potentially
prevent
delay
onset
neurodegenerative
diseases.
The
proteomic
profile
AD/PD
cases
was
comorbid
systems
conditions.
Importantly,
developed
prediction
models
clinical,
genetic,
demographic
data,
combination
which
performs
better
than
any
single
paradigm
approach
classification.
This
work
aims
illuminate
intricate
interplay
between
various
physiological
factors
involved
development
PD,
providing
multifactorial
systemic
understanding
goes
beyond
traditional
approaches.
Язык: Английский
Dietary Anthocyanin Intake, Genetic Risk, and Incident Ulcerative Colitis: A Prospective Cohort Study
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
ABSTRACT
Summary
evidence
from
animal
experiments
indicates
that
anthocyanin
supplements
can
contribute
to
intestinal
health.
Nevertheless,
no
has
linked
dietary
anthocyanins
the
prevention
potential
against
inflammatory
bowel
disease
(IBD)
in
humans.
We
leveraged
data
188,044
IBD‐free
individuals
(mean
age
59
years;
55.2%
females)
prospective
cohort
UK
Biobank.
The
intake
was
estimated
using
information
validated
24
h
recalls.
Incident
IBD
ascertained
via
national
health‐related
records.
Genetic
susceptibility
Crohn's
(CD)
and
ulcerative
colitis
(UC)
by
polygenic
risk
scores
further
categorized
into
low‐
high‐risk
groups
median
value.
Cox
proportional
regression
model
applied
estimate
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs).
During
mean
follow‐up
of
9.7
years,
we
documented
255
CD
606
UC.
found
compared
with
participants
lowest
quartiles
intake,
those
highest
were
associated
24%
(95%
CI
6%–38%,
p
=
0.012;
‐trend
0.003)
35%
16%–49%,
0.001;
<
0.001)
reduced
UC,
respectively.
inverse
associations
stronger
(
‐interaction
0.022)
among
a
high
genetic
did
not
observe
significant
association
between
0.536).
Higher
but
CD.
factors
may
modify
influence
on
UC
susceptibility,
possible
mechanisms
need
be
elucidated
future.
Язык: Английский
Adherence to the Mediterranean diet is associated with reduced chronic pancreatitis risk: A longitudinal cohort study
Food & Function,
Год журнала:
2024,
Номер
15(22), С. 11072 - 11082
Опубликована: Янв. 1, 2024
:
The
role
of
diet
on
the
risk
chronic
pancreatitis
(CP)
is
understudied.
health
benefits
Mediterranean
(MedDiet)
pattern
have
long
been
recognized,
but
its
association
with
CP
unclear.
We
aimed
to
investigate
between
adherence
MedDiet
and
incidence
in
a
large-scale
cohort.
Язык: Английский
Joint effect of polysocial risk score, lifestyle and genetic susceptibility with the risk of dementia: A prospective cohort study
Journal of Affective Disorders,
Год журнала:
2024,
Номер
370, С. 229 - 234
Опубликована: Ноя. 4, 2024
Язык: Английский
Association of Autoimmune Disorders and Disease-modifying Antirheumatic Drugs: (DMARDs) with the Risk of Alzheimer’s and/or Dementia: A Population Study Using Medicare Beneficiary Data
Current Alzheimer Research,
Год журнала:
2023,
Номер
20(10), С. 725 - 737
Опубликована: Окт. 1, 2023
Alzheimer's
disease
(AD)
and/or
dementia
is
a
prevalent
neurocognitive
disorder
primarily
affecting
individuals
over
the
age
of
65.
Identifying
specific
causes
AD
can
be
challenging,
with
emerging
evidence
suggesting
potential
association
autoimmune
inflammatory
conditions
such
as
rheumatoid
arthritis
(RA).
This
study
aimed
to
assess
prevalence
rate
among
Medicare
beneficiaries
reporting
an
disorder.
Additionally,
this
sought
identify
comparative
in
patients
who
were
using
disease-modifying
antirheumatic
drugs
(DMARDs)
compared
those
not
DMARDs.
Язык: Английский