Association of Autoimmune Disorders and Disease-modifying Antirheumatic Drugs: (DMARDs) with the Risk of Alzheimer’s and/or Dementia: A Population Study Using Medicare Beneficiary Data DOI
Qian Ding, Jennifer T. Lamberts, Ali Konieczny

et al.

Current Alzheimer Research, Journal Year: 2023, Volume and Issue: 20(10), P. 725 - 737

Published: Oct. 1, 2023

Alzheimer's disease (AD) and/or dementia is a prevalent neurocognitive disorder primarily affecting individuals over the age of 65. Identifying specific causes AD can be challenging, with emerging evidence suggesting potential association autoimmune inflammatory conditions such as rheumatoid arthritis (RA). This study aimed to assess prevalence rate among Medicare beneficiaries reporting an disorder. Additionally, this sought identify comparative in patients who were using disease-modifying antirheumatic drugs (DMARDs) compared those not DMARDs.

Language: Английский

Systemic determinants of brain health in ageing DOI
Eric E. Smith, Geert Jan Biessels, Virginia Gao

et al.

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(11), P. 647 - 659

Published: Oct. 7, 2024

Language: Английский

Citations

5
Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study DOI Creative Commons
Stefan Teipel, Manas K. Akmatov,

Bernhard Michalowsky

et al.

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 16, 2025

Many risk factors for dementia have been identified, but the timing of is less well understood. Here, we analyzed in a case-control study covering 10 years before an incident diagnosis. We designed using insurance claims outpatient consultations patients with German statutory health between January 1, 2012, and December 31, 2022. included diagnosis controls without matched 1:2 age, sex, region, earliest year encounter. selected exposures based on previous systematic reviews, cohort studies reporting factors, comorbidities, prodromal features dementia. calculated prevalence cases odds ratios each index date, along Bonferroni-corrected confidence intervals, conditional logistic regression. identified total 1,686,759 (mean (SD) 82.15 (6.90) years; 61.70% female) 3,373,518 female). Study participants were followed up mean 6.6 (2.3) years. Of 63 examined, 56 associated increased all during 10th 1st date. These established such as depression, hypertension, hearing impairment, nicotine alcohol abuse, obesity, hypercholesterolaemia, traumatic brain injury, diabetes. The greatest risk, greater than 2.5, was conferred by delirium, memory mental retardation, personality behavioral disorders, sensory schizophrenia, psychosis. Cancer reduced This large confirmed In addition, non-specific diagnoses that showed steep increase close to psychosis, conduct disorder, other disorders. Consideration these diagnoses, which may represent rather dementia, help identify people routine care.

Language: Английский

Citations

0
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis DOI Creative Commons

Guido Petracco,

Isabella Faimann, Florian Reichmann

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108831 - 108831

Published: Feb. 1, 2025

Language: Английский

Citations

0
Risk of dementia in different types of cancer survivors: A nationwide cohort study DOI
Che‐Sheng Chu,

Shu-Li Cheng,

Yamei Bai

et al.

American Journal of Geriatric Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

Citations

1
Gut-Brain Nexus: Mapping Multi-Modal Links to Neurodegeneration at Biobank Scale DOI Creative Commons

Mohammad Shafieinouri,

Samantha Hong, Artur Francisco Schumacher Schuh

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Abstract Alzheimer’s disease (AD) and Parkinson’s (PD) are influenced by genetic environmental factors. Using data from UK Biobank, SAIL FinnGen, we conducted an unbiased, population-scale study to: 1) Investigate how 155 endocrine, nutritional, metabolic, digestive system disorders associated with AD PD risk prior to their diagnosis, considering known influences; 2) Assess plasma biomarkers’ specificity for or in individuals these conditions; 3) Develop a multi-modal classification model integrating genetics, proteomics, clinical relevant conditions affecting the gut-brain axis. Our findings show that certain elevate before diagnosis including: insulin non-insulin dependent diabetes mellitus, noninfective gastro-enteritis colitis, functional intestinal disorders, bacterial infections, among others. Polygenic scores revealed lower predisposition co-occurring categories, underscoring importance of regulating axis potentially prevent delay onset neurodegenerative diseases. The proteomic profile AD/PD cases was comorbid systems conditions. Importantly, developed prediction models clinical, genetic, demographic data, combination which performs better than any single paradigm approach classification. This work aims illuminate intricate interplay between various physiological factors involved development PD, providing multifactorial systemic understanding goes beyond traditional approaches.

Language: Английский

Citations

0
Dietary Anthocyanin Intake, Genetic Risk, and Incident Ulcerative Colitis: A Prospective Cohort Study DOI Creative Commons

Sishen Sun,

Danshu Wang,

Lintao Dan

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

ABSTRACT Summary evidence from animal experiments indicates that anthocyanin supplements can contribute to intestinal health. Nevertheless, no has linked dietary anthocyanins the prevention potential against inflammatory bowel disease (IBD) in humans. We leveraged data 188,044 IBD‐free individuals (mean age 59 years; 55.2% females) prospective cohort UK Biobank. The intake was estimated using information validated 24 h recalls. Incident IBD ascertained via national health‐related records. Genetic susceptibility Crohn's (CD) and ulcerative colitis (UC) by polygenic risk scores further categorized into low‐ high‐risk groups median value. Cox proportional regression model applied estimate hazard ratios (HRs) 95% confidence intervals (CIs). During mean follow‐up of 9.7 years, we documented 255 CD 606 UC. found compared with participants lowest quartiles intake, those highest were associated 24% (95% CI 6%–38%, p = 0.012; ‐trend 0.003) 35% 16%–49%, 0.001; < 0.001) reduced UC, respectively. inverse associations stronger ( ‐interaction 0.022) among a high genetic did not observe significant association between 0.536). Higher but CD. factors may modify influence on UC susceptibility, possible mechanisms need be elucidated future.

Language: Английский

Citations

0
Adherence to the Mediterranean diet is associated with reduced chronic pancreatitis risk: A longitudinal cohort study DOI Creative Commons
Chunhua Zhou,

Jiawei Geng,

Hanyi Huang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(22), P. 11072 - 11082

Published: Jan. 1, 2024

: The role of diet on the risk chronic pancreatitis (CP) is understudied. health benefits Mediterranean (MedDiet) pattern have long been recognized, but its association with CP unclear. We aimed to investigate between adherence MedDiet and incidence in a large-scale cohort.

Language: Английский

Citations

0
Joint effect of polysocial risk score, lifestyle and genetic susceptibility with the risk of dementia: A prospective cohort study DOI

Lichao Yang,

Ziqing Sun, Qida He

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 370, P. 229 - 234

Published: Nov. 4, 2024

Language: Английский

Citations

0
Association of Autoimmune Disorders and Disease-modifying Antirheumatic Drugs: (DMARDs) with the Risk of Alzheimer’s and/or Dementia: A Population Study Using Medicare Beneficiary Data DOI
Qian Ding, Jennifer T. Lamberts, Ali Konieczny

et al.

Current Alzheimer Research, Journal Year: 2023, Volume and Issue: 20(10), P. 725 - 737

Published: Oct. 1, 2023

Alzheimer's disease (AD) and/or dementia is a prevalent neurocognitive disorder primarily affecting individuals over the age of 65. Identifying specific causes AD can be challenging, with emerging evidence suggesting potential association autoimmune inflammatory conditions such as rheumatoid arthritis (RA). This study aimed to assess prevalence rate among Medicare beneficiaries reporting an disorder. Additionally, this sought identify comparative in patients who were using disease-modifying antirheumatic drugs (DMARDs) compared those not DMARDs.

Language: Английский

Citations

0