PM2.5 exacerbates nasal epithelial barrier dysfunction in allergic rhinitis by inducing NLRP3-mediated pyroptosis via the AhR/CYP1A1/ROS axis
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
unknown, С. 138145 - 138145
Опубликована: Апрель 1, 2025
Язык: Английский
How does pollution worsen allergies?
Annals of Allergy Asthma & Immunology,
Год журнала:
2024,
Номер
132(4), С. 407 - 408
Опубликована: Апрель 1, 2024
Язык: Английский
Exploring the Mechanism of Bufei Decoction in the Treatment of Bronchial Asthma Based on Network Pharmacology and Molecular Docking
Yongguang Han,
Xing Lv,
Ya-Lan Tan
и другие.
Combinatorial Chemistry & High Throughput Screening,
Год журнала:
2024,
Номер
28(5), С. 768 - 780
Опубликована: Апрель 13, 2024
Bufei
decoction
(BFD)
is
used
in
clinical
practice
to
treat
bronchial
asthma
(BA),
although
its
molecular
mechanism
of
action
remains
unclear.
This
study
aimed
explore
the
BFD
for
treating
BA.
Network
pharmacology
and
docking
predicted
analysis
results
were
verified
using
ELISA
kit
RT-qPCR.
There
58
main
active
components
121
potential
targets
from
Traditional
Chinese
Medicine
Systems
Pharmacology
Database
Analysis
Platform(
TCMSP),
11
core
obtained
protein-protein
interactions(PPI)
network.
The
gene
ontology
(GO)
found
that
treatment
BA
with
was
mainly
related
inflammatory
reaction,
membrane
raft,
cytokine
activity,
etc.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
showed
it
interleukin
(IL)-17
signaling
pathway,
tumor
necrosis
factor
(TNF)
PI3KAkt
ingredients
had
strong
binding
ability
targets.
significantly
reduced
TNF-α,
IL-6,
IL-1β
increased
level
IL-10
rats
also
mRNA
PI3K,
AKT1,
VEGFA
while
increasing
TP53
rats.
network
methods
predict
ingredients,
targets,
pathways
possible
mechanism,
which
provided
a
theoretical
basis
further
study.
Язык: Английский
Persistent organic pollutants among seafood processing workers in West Greenland
International Journal of Hygiene and Environmental Health,
Год журнала:
2024,
Номер
263, С. 114484 - 114484
Опубликована: Ноя. 7, 2024
Язык: Английский
Epithelial-immune interactions govern type 2 immunity at barrier surfaces
Current Opinion in Immunology,
Год журнала:
2024,
Номер
91, С. 102501 - 102501
Опубликована: Ноя. 10, 2024
Язык: Английский
Trends in allergic sensitization and diseases in the Korean general population over a 9-year period
Clinical and Experimental Otorhinolaryngology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
The
prevalence
of
HDM
sensitization
remained
stable
over
9
years
in
the
Korean
general
population.
Dog
among
adolescents
increased
2019
compared
to
2010.
Clinicodemographic
factors
associated
differed
between
age
groups
and
years.
Язык: Английский