PM2.5 exacerbates nasal epithelial barrier dysfunction in allergic rhinitis by inducing NLRP3-mediated pyroptosis via the AhR/CYP1A1/ROS axis
JiaSheng Yuan,
No information about this author
Zhongxing Liao,
No information about this author
Xinhua Zhu
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et al.
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
unknown, P. 138145 - 138145
Published: April 1, 2025
Language: Английский
How does pollution worsen allergies?
Annals of Allergy Asthma & Immunology,
Journal Year:
2024,
Volume and Issue:
132(4), P. 407 - 408
Published: April 1, 2024
Language: Английский
Exploring the Mechanism of Bufei Decoction in the Treatment of Bronchial Asthma Based on Network Pharmacology and Molecular Docking
Yongguang Han,
No information about this author
Xing Lv,
No information about this author
Ya-Lan Tan
No information about this author
et al.
Combinatorial Chemistry & High Throughput Screening,
Journal Year:
2024,
Volume and Issue:
28(5), P. 768 - 780
Published: April 13, 2024
Bufei
decoction
(BFD)
is
used
in
clinical
practice
to
treat
bronchial
asthma
(BA),
although
its
molecular
mechanism
of
action
remains
unclear.
This
study
aimed
explore
the
BFD
for
treating
BA.
Network
pharmacology
and
docking
predicted
analysis
results
were
verified
using
ELISA
kit
RT-qPCR.
There
58
main
active
components
121
potential
targets
from
Traditional
Chinese
Medicine
Systems
Pharmacology
Database
Analysis
Platform(
TCMSP),
11
core
obtained
protein-protein
interactions(PPI)
network.
The
gene
ontology
(GO)
found
that
treatment
BA
with
was
mainly
related
inflammatory
reaction,
membrane
raft,
cytokine
activity,
etc.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
showed
it
interleukin
(IL)-17
signaling
pathway,
tumor
necrosis
factor
(TNF)
PI3KAkt
ingredients
had
strong
binding
ability
targets.
significantly
reduced
TNF-α,
IL-6,
IL-1β
increased
level
IL-10
rats
also
mRNA
PI3K,
AKT1,
VEGFA
while
increasing
TP53
rats.
network
methods
predict
ingredients,
targets,
pathways
possible
mechanism,
which
provided
a
theoretical
basis
further
study.
Language: Английский
Persistent organic pollutants among seafood processing workers in West Greenland
International Journal of Hygiene and Environmental Health,
Journal Year:
2024,
Volume and Issue:
263, P. 114484 - 114484
Published: Nov. 7, 2024
Language: Английский
Epithelial-immune interactions govern type 2 immunity at barrier surfaces
Current Opinion in Immunology,
Journal Year:
2024,
Volume and Issue:
91, P. 102501 - 102501
Published: Nov. 10, 2024
Language: Английский
Trends in allergic sensitization and diseases in the Korean general population over a 9-year period
Clinical and Experimental Otorhinolaryngology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
The
prevalence
of
HDM
sensitization
remained
stable
over
9
years
in
the
Korean
general
population.
Dog
among
adolescents
increased
2019
compared
to
2010.
Clinicodemographic
factors
associated
differed
between
age
groups
and
years.
Language: Английский