Biofluid, Imaging, Physiological and Functional Biomarkers of Mild Traumatic Brain Injury and Subconcussive Head Impacts

Journal of Neurotrauma, Год журнала: 2024, Номер unknown

Опубликована: Июль 18, 2024

Post-concussive symptoms are frequently reported by individuals who sustain mild traumatic brain injuries (mTBIs) and subconcussive head impacts, even when evidence of intracranial pathology is lacking. Current strategies used to evaluate injuries, which primarily rely on self-report, have a limited ability predict the incidence, severity, duration post-concussive that will develop in an individual patient. In addition, these self-report measures little association with underlying mechanisms may contribute persisting symptoms, impeding advancement precision treatment for TBI. Emerging suggests biofluid, imaging, physiological, functional biomarkers associated mTBI impacts address shortcomings providing more objective injury severity pathology. Interest use biomarker data has rapidly accelerated, reflected recent efforts organizations such as National Institute Neurological Disorders Stroke Academies Sciences, Engineering, Medicine prioritize collection during TBI characterization acute-care settings. Thus, this review aims describe progress identification development discuss important considerations implementation clinical practice.

Язык: Английский

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Early Childhood Concussion

PEDIATRICS, Год журнала: 2024, Номер 154(5)

Опубликована: Окт. 9, 2024

The unconsolidated motor and cognitive skills that are typical of the early childhood period place infants, toddlers, preschoolers at risk for a variety traumatic injuries. Such injuries may include mild brain injury or concussion. Knowledge regarding risk, diagnosis, outcomes, management concussion is limited, especially compared with what known about in school-age children, adolescents, adults. This state-of-the-art review aims to provide current knowledge on epidemiology, physical signs, behavior, clinical outcomes associated Research this condition has been challenged by need adapt methods unique physical, behavioral, developmental characteristics young children. We information observable symptoms concussion, recommended approaches care, suggestions overcoming barriers research area. Developmentally appropriate efforts needed improve our ability identify, evaluate, treat

Язык: Английский

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Repetitive Head Injury and Cognitive, Physical, and Emotional Symptoms in Women Survivors of Intimate Partner Violence

Journal of Neurotrauma, Год журнала: 2023, Номер 41(3-4), С. 486 - 498

Опубликована: Сен. 11, 2023

Many women survivors of intimate partner violence (IPV) experience repetitive head injuries in their lifetime, but limited research has examined the cumulative effects multiple on post-concussion symptom severity this population. This study how number lifetime and episodes loss consciousness (LOC) due to were related current cognitive, physical, emotional symptoms among IPV. Cisgender from Kentucky recruited following a protective order against an partner, including 268 with no reported 250 one or more IPV-related (mean [M] = 17.2 injuries, standard deviation [SD] 50.5, median [Mdn] 4, range 1-515; M 1.8 LOC episodes, SD 4.3, Mdn 1, 0-35, respectively). Participants underwent in-person interviews about physical sexual IPV history, injury symptoms. Sociodemographic characteristics, severity, relation episodes. A higher was associated greater age, White race, less than high school education, unemployment, rural residence. No sociodemographic variables differed based Greater correlated significantly (

Язык: Английский

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Refinement of a Preliminary Case Definition for Use in Traumatic Brain Injury Surveillance

Journal of Head Trauma Rehabilitation, Год журнала: 2023, Номер unknown

Опубликована: Дек. 1, 2023

Current methods used to measure incidence of traumatic brain injury (TBI) underestimate its true public health burden. The use self-report surveys may be an approach improve these estimates. An important step in surveillance is define a problem using case definition. purpose this article outline the process that Centers for Disease Control and Prevention undertook refine TBI definition survey.

Язык: Английский

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Pituitary dysfunction following mild traumatic brain injury in female athletes

Endocrine Connections, Год журнала: 2023, Номер 13(2)

Опубликована: Дек. 11, 2023

Objective Pituitary dysfunction following mild traumatic brain injury can have serious physical and psychological consequences, making correct diagnosis treatment essential. To the best of our knowledge, this study is first to prevalence pituitary in an all-female population detailed endocrinological work-up after screening for female athletes. Design This a retrospective cohort study. Methods Hormone blood tests, including serum values thyroid-stimulating hormone, free thyroxin, insulin-like growth factor 1, prolactin, cortisol, follicle-stimulating luteinizing estrogen progesterone, were taken 133 Results repeatedly outside reference value 88 women necessitating further evaluation. Two those lost follow-up, evaluation was performed 86 participants. Six (4.6%, n = 131) diagnosed with hypopituitarism, four (3.1%) central hypothyroidism two hormone deficiency (1.5%). Ten (7.6%) had hyperprolactinemia, them prolactinoma. Medical initiated 13 (9.9%) women. Significant prognostic factors not found. Conclusions As 12.2% athletes history (hypopituitarism 4.6%, hyperprolactinemia 7.6%), we conclude that important consideration post-concussion care. Hyperprolactinemia absence prolactinoma may represent or hypothalamic injury. Significance statement Mild (mTBI) has become growing public health concern as 50 million people worldwide sustain annually, mTBI being most common (70–90%). studies on focused mostly male populations aims explore (PD) mTBI. it PD The found participating (4.6%) hypopituitarism ten hyperprolactinemia. These findings suggest endocrinologists other medical staff working need be aware of.

Язык: Английский

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