Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2285 - 2285
Опубликована: Сен. 5, 2023
Diabetic
ulcers
are
the
second
largest
complication
caused
by
diabetes
mellitus.
A
great
number
of
factors,
including
hyperchromic
inflammation,
susceptible
microbial
infection,
inferior
vascularization,
large
accumulation
free
radicals,
and
other
poor
healing-promoting
microenvironments
hold
back
healing
process
chronic
diabetic
ulcer
in
clinics.
With
increasing
clinical
cases
worldwide,
design
development
advanced
wound
dressings
urgently
required
to
accelerate
treatment
skin
wounds
complications.
Electrospinning
technology
has
been
recognized
as
a
simple,
versatile,
cost-reasonable
strategy
fabricate
dressing
materials
composed
nanofibers,
which
possess
excellent
extracellular
matrix
(ECM)-mimicking
morphology,
structure,
biological
functions.
The
electrospinning-based
nanofibrous
have
widely
demonstrated
promote
adhesion,
migration,
proliferation
dermal
fibroblasts,
further
compared
with
some
types
like
traditional
cotton
gauze
medical
sponges,
etc.
Moreover,
electrospun
nanofibers
commonly
harvested
structure
nonwoven-like
mats,
small
pore
sizes
but
high
porosity,
resulting
barrier
performance
well
moisture
air
permeable
properties.
They
also
serve
good
carriers
load
various
bioactive
agents
and/or
even
living
cells,
impart
predetermined
functions
multiple
significantly
improve
outcomes
different
while
dramatically
shortening
procedure.
All
these
outstanding
characteristics
made
one
most
promising
candidates
for
ulcers.
This
review
starts
brief
introduction
electrospinning
process,
then
provides
detailed
recent
advances
strategies
wounds.
Importantly,
synergetic
application
combining
ingredients
cell
therapy
was
highlighted.
discussed
advantages
hydrogel
using
nanofibers.
At
end
review,
challenge
prospects
depth.
Heliyon,
Год журнала:
2023,
Номер
9(5), С. e16228 - e16228
Опубликована: Май 1, 2023
The
use
of
gelatin
and
gelatin-blend
polymers
as
environmentally
safe
to
synthesis
electrospun
nanofibers,
has
caused
a
revolution
in
the
biomedical
field.
development
efficient
nanofibers
played
significant
role
drug
delivery,
for
advanced
scaffolds
regenerative
medicine.
Gelatin
is
an
exceptional
biopolymer,
which
highly
versatile,
despite
variations
processing
technology.
electrospinning
process
technique
manufacture
(GNFs),
it
simple,
efficient,
cost-effective.
GNFs
have
higher
porosity
with
large
surface
area
biocompatibility,
that
there
are
some
drawbacks.
These
drawbacks
include
rapid
degradation,
poor
mechanical
strength,
complete
dissolution,
limits
this
form
biomedicine.
Thus,
these
fibers
need
be
cross-linked,
order
control
its
solubility.
This
modification
improvement
biological
properties
GNFs,
made
them
suitable
candidates
various
applications,
such
wound
healing,
bone
regeneration,
tubular
scaffolding,
skin,
nerve,
kidney,
cardiac
tissue
engineering.
In
review
outline
shown
critical
summary
literature
evaluated
respect
applications
nanofibers-derived
gelatin.
Materials & Design,
Год журнала:
2023,
Номер
237, С. 112623 - 112623
Опубликована: Дек. 30, 2023
The
treatment
of
tenacious
diabetic
wounds
still
remains
an
enormous
challenge
in
clinics,
originated
from
the
complicated
pathological
microenvironment
wound
sites.
Therefore,
it's
urgently
required
to
develop
one
type
innovative
dressing
patch
with
appropriate
microstructure
and
multifunctions
regulate
promote
regeneration
wounds.
In
this
study,
novel
gelatin
(Gel)/poly
(L-lactic
acid)
(PLLA)
nanofibrous
yarns
loading
or
without
Salvia
miltiorrhiza
Bunge-Radix
Puerariae
herbal
compound
(SRHC)
are
fabricated
by
using
our
modified
electrospinning
strategy,
which
further
interlaced
into
woven
fabrics
respectively,
serving
as
biofunctional
patches
for
potential
application.
actual
photographs
SEM
images
confirm
that
all
different
textiles
SRHC
exhibited
a
uniform
interwoven
structure
warp
weft,
internal
nanofibers
present
bead-free
morphology
uniaxially
oriented
along
longitudinal
axis
yarns.
Moreover,
demonstrated
possess
strong
mechanical
properties
great
surface
wettability.
vitro
cell
characterization
shows
addition
can
significantly
attachment
proliferation
human
dermal
fibroblasts
(HDFs),
also
dramatically
inhibit
secretion
levels
proinflammatory
factors
M1
macrophages.
vivo
mouse
full-thickness
skin
model
experiments
reveal
as-developed
SRHC-loaded
Gel/PLLA
textile
best
performances
referring
short
healing
time
(100
%
closure
after
18
days
treatment)
high-quality
(i.e.,
enhance
collagen
deposition,
improve
re-epithelialization
neovascularization,
increase
hair
follicles),
assuredly
finds
interests
hard-to-heal
Biomimetics,
Год журнала:
2023,
Номер
8(1), С. 130 - 130
Опубликована: Март 22, 2023
Inducing
tissue
regeneration
in
many
skin
defects,
such
as
large
traumatic
wounds,
burns,
other
physicochemical
bedsores,
and
chronic
diabetic
ulcers,
has
become
an
important
clinical
issue
recent
years.
Cultured
cell
sheets
scaffolds
containing
growth
factors
are
already
use
but
have
yet
to
restore
normal
structure
function.
Many
engineering
materials
that
focus
on
the
process
of
living
tissues
been
developed
for
more
versatile
rapid
initiation
treatment.
Since
discovery
cells
recognize
chemical-physical
properties
their
surrounding
environment,
there
a
great
deal
work
mimicking
composition
extracellular
matrix
(ECM)
its
three-dimensional
network
structure.
Approaches
used
ECM
constituent
proteins
well
morphological
processing
methods,
fiber
sheets,
sponges,
meshes.
This
review
summarizes
material
design
strategies
fields,
ranging
from
morphology
existing
dressings
structures
cellular-level
microstructure
mimicry,
explores
directions
future
approaches
precision
regeneration.
Materials & Design,
Год журнала:
2024,
Номер
239, С. 112818 - 112818
Опубликована: Фев. 29, 2024
The
long-term
exposure
of
skin
wounds,
especially
for
those
chronic
is
commonly
accompanied
with
the
bacterial
infection,
which
further
holds
back
wound
healing
process.
Therefore,
it's
urgently
required
to
develop
innovative
dressings
both
antibacterial
property
and
healing-promoting
function.
In
this
study,
a
series
novel
hydrogel
constructed
polyasparthydrazide
(PAHy)
nanofibers
different
concentrations
in-situ
synthesized
silver
nanoparticles
(AgNPs)
were
designed
prepared.
It
was
found
that
all
PAHy
nanofiber
mats
without
or
AgNPs
exhibited
uniform
bead-free
nanofibrous
structure,
AgNPs-contained
showed
obviously
decreased
fiber
diameters
compared
pure
mat.
mechanical
properties
as-prepared
PAHy/AgNPs
in
dry
condition
significantly
larger
than
wet
condition,
appropriate
addition
could
improve
some
extent.
water
swelling
ratio
be
increasing
content.
mat
prepared
polysuccinimide
(PSI)
0.5
wt%
nitrate
(AgNO3),
named
as
PAHy/AgNPs-0.5
mat,
displayed
higher
cumulative
release
rate
(9.4
±
1.1
%)
after
72
h,
it
demonstrated
possess
excellent
rates
against
E.
coli
(99.99
S.
aureus
%),
clear
inhibition
zones
diameter
1.0
0.1
mm
5.8
0.3
aureus.
Importantly,
animal
studies
accelerate
process
by
promoting
re-epithelialization
collagen
deposition
site,
possessed
huge
potential
serving
advanced
dressing
materials
infected
treatment.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
A
dressing
patch
made
of
radially
oriented
poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
(PHBV)
nanofibers
was
successfully
manufactured
with
a
modified
electrospinning
strategy.
The
as-electrospun
PHBV
nanofiber
exhibited
uniform
and
bead-free
nanofibrous
morphology
innovative
arrangement,
which
demonstrated
to
possess
obviously
improved
mechanical
property,
increased
surface
hydrophilicity
enhanced
biological
properties
compared
the
control
traditionally
randomly
pattern.
Interestingly,
it
found
that
pattern
could
induce
cell
migration
from
periphery
center
along
in
rapid
manner.
To
further
improve
biofunction
patch,
berberine
(Beri,
an
isoquinoline
alkaloid)
two
different
concentrations
were
encapsulated
into
during
electrospinning,
present
sustained
drug
release
behavior
for
nearly
one
month.
Importantly,
addition
Beri
impart
excellent
anti-inflammatory
property
by
significantly
inhibiting
secretion
pro-inflammatory
factors
M1
macrophages,
also
showed
additive
influence
on
promoting
proliferation
human
dermal
fibroblasts
(HDFs),
as
well
growth
E.
coli,
S.
aureus
C.
albicans,
Beri-free
patch.
In
animal
studies,
electrospun
loading
high
content
accelerate
healing
process
diabetic
mouse
full-thickness
skin
wound
shortened
time
(100%
closure
rate
after
18
days’
treatment)
quality
(improved
collagen
deposition,
re-epithelialization
neovascularization
hair
follicles).
all,
this
study
reported
therapeutic
strategy
integrating
physical
cues
multiple
effective
treatment
hard-to-heal
wounds.
Nanomaterials,
Год журнала:
2022,
Номер
12(17), С. 2933 - 2933
Опубликована: Авг. 25, 2022
The
design
and
development
of
novel
dressing
materials
are
urgently
required
for
the
treatment
chronic
wounds
caused
by
diabetic
ulcers
in
clinics.
In
this
study,
ursolic
acid
(UA)
extracted
from
Chinese
herbal
plants
was
encapsulated
into
electrospun
nanofibers
made
a
blend
chitosan
(CS)
polyvinyl
alcohol
(PVA)
to
generate
innovative
CS-PVA-UA
dressings
wound
treatment.
as-prepared
nanofiber
mats
exhibited
randomly
aligned
fiber
morphology
with
mean
diameters
range
100-200
nm,
possessing
great
morphological
resemblance
collagen
fibrils
which
exist
native
skin
extracellular
matrix
(ECM).
addition,
were
found
possess
good
surface
hydrophilicity
wettability,
sustained
UA
release
behavior.
vitro
biological
tests
showed
that
high
concentration
could
lead
slight
cytotoxicity.
It
also
significantly
reduce
M1
phenotypic
transition
macrophages
even
stimulated
lipopolysaccharide
(LPS)
effectively
restore
M2
polarization
shorten
inflammatory
period.
Moreover,
appropriate
introduction
CS-PVA
decreased
levels
TNF-α
IL-6
factors,
suppressed
oxidative
stress
responses
reducing
generation
reactive
oxygen
species
(ROS)
as
well.
results
mouse
hepatic
hemorrhage
displayed
possessed
excellent
hemostatic
performance.
vivo
animal
experiments
improve
closure
rate,
promote
revascularization
re-epithelization,
well
deposition
remodeling
regeneration
hair
follicles
wounds.
Specifically,
contraction
rate
using
reach
99.8%
after
18
days
summary,
our
present
study
offers
promising
nanofibrous
candidate
multiple
functions,
including
anti-inflammation,
antioxidation,
pro-angiogenesis,
hemostasis
hard-to-heal
