Tropical Journal of Natural Product Research,
Год журнала:
2024,
Номер
8(12)
Опубликована: Дек. 29, 2024
Argan
oil
is
a
highly
sought-after
natural
product
renowned
for
its
therapeutic
and
rejuvenating
properties.
This
study
focused
on
harnessing
dermatological
bioactivity
by
developing
stable
nanoemulsions
through
simple
low-energy
method
using
single
non-ionic
surfactant.
The
composition
properties
of
were
analyzed
High-Performance
Liquid
Chromatography
(HPLC),
Gas
(GC),
quality
indexes,
adhering
to
international
standards.
effect
system
stability
was
evaluated
pseudo-ternary
phase
diagram
Phase
Inversion
Composition
(PIC)
emulsification
technique.
Optimal
process
parameters
producing
nanoemulsion
determined
Response
Surface
Methodology
(RSM)
analysis.
resulting
characterized
storage
stability,
average
droplet
size,
Polydispersity
Index
(PDI)
Dynamic
Light
Scattering
(DLS).
physicochemical
bioactive
compounds
identified,
including
total
tocopherol
content
841
±35
mg/kg
phenolic
83.81
±0.71
mg
Gallic
Acid
Equivalent
(GAE)
per
kg
oil,
highlighting
potential.
ideal
established,
behavior
monitored
alongside
ensure
the
formation
nanoemulsion.
Stability
analysis
confirmed
physical
over
time
under
various
conditions.
Size
revealed
small
size
(130.154
±0.115
nm)
narrow
distribution
(0.019
±0.003
nm).
PIC
successfully
produced
low-speed
stirring
surfactant,
requiring
no
additional
compounds.
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1384 - 1384
Опубликована: Окт. 28, 2024
Dermatoses
are
among
the
most
prevalent
non-fatal
conditions
worldwide.
Given
this
context,
it
is
imperative
to
introduce
safe
and
effective
dermatological
treatments
address
diverse
needs
concerns
of
individuals.
Transdermal
delivery
technology
offers
a
promising
alternative
compared
traditional
administration
methods
such
as
oral
or
injection
routes.
Therefore,
review
focuses
on
recent
achievements
nanocarrier-based
transdermal
for
therapy,
which
summarizes
strategies
enhance
skin
penetration
using
various
nanocarriers
including
vesicular
nanocarriers,
lipid-based
emulsion-based
polymeric
nanocarrier
according
pathogenesis
common
dermatoses.
The
fundamentals
physiology
structure
routes
introduced.
Moreover,
mechanisms
due
utilization
hydration,
system
deformability,
disruption
stratum
corneum,
surface
charge,
tunable
particle
size
outlined
well.
Journal of Taibah University Medical Sciences,
Год журнала:
2024,
Номер
19(4), С. 806 - 815
Опубликована: Июль 22, 2024
Dasatinib
(DS),
a
second-generation
tyrosine
kinase
inhibitor,
functions
as
multi-target
small-molecule
drug
via
targeting
various
kinases
involved
in
neoplastic
cell
growth.
DS
inhibits
cancer
replication
and
migration,
induces
tumor
apoptosis
variety
of
solid
tumors.
However,
it
is
poorly
soluble
water
under
some
pH
values.
Therefore,
the
development
DS-containing,
self-emulsifying,
delivery
system
(SeDDs)
could
help
overcome
these
problems
treating
cells.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 205 - 205
Опубликована: Фев. 6, 2025
Cancer
represents
a
significant
societal,
public
health,
and
economic
challenge.
Conventional
chemotherapy
is
based
on
systemic
administration;
however,
it
has
current
limitations,
including
poor
bioavailability,
high-dose
requirements,
adverse
side
effects,
low
therapeutic
indices,
the
development
of
multiple
drug
resistance.
These
factors
underscore
need
for
innovative
strategies
to
enhance
delivery
directly
tumours.
However,
local
treatment
also
presents
challenges,
penetration
through
endothelial
layers,
tissue
density
in
tumour
microenvironment,
interstitial
fluid
pressure,
physiological
conditions
within
tumour,
permanence
at
site
action.
Nanotechnology
promising
alternative
addressing
these
challenges.
This
narrative
review
elucidates
potential
nanostructured
formulations
cancer
treatment,
providing
illustrative
examples
an
analysis
advantages
challenges
associated
with
this
approach.
Among
nanoformulations
developed
breast,
bladder,
colorectal,
oral,
melanoma
cancer,
polymeric
nanoparticles,
liposomes,
lipid
nanohydrogels
have
demonstrated
particular
efficacy.
systems
permit
mucoadhesion
enhanced
penetration,
thereby
increasing
concentration
(bioavailability)
consequently
improving
anti-tumour
efficacy
potentially
reducing
effects.
In
addition
studies
indicating
chemotherapy,
nanocarriers
can
be
used
as
theranostic
approach
combination
irradiation
methods.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 337 - 337
Опубликована: Март 5, 2025
Nanoemulsions
(NEs)
have
emerged
as
effective
drug
delivery
systems
over
the
past
few
decades
due
to
their
multifaceted
nature,
offering
advantages
such
enhanced
bioavailability,
protection
of
encapsulated
compounds,
and
low
toxicity.
In
present
review,
we
focus
on
advancements
in
last
five
years
across
(trans)dermal,
oral,
ocular,
nasal,
intra-articular
administration
routes
using
NEs.
Rational
selection
components,
surface
functionalization,
incorporation
permeation
enhancers,
functionalization
with
targeting
moieties
are
explored
for
each
route
discussed.
Additionally,
apart
from
NEs,
explore
NE-based
(e.g.,
gels)
while
highlighting
emerging
approaches
vaccination
theranostic
applications.
The
growing
interest
NEs
purposes
is
reflected
clinical
trials,
which
also
By
summarizing
latest
advances,
exploring
new
strategies,
identifying
critical
challenges,
this
review
focuses
developments
efficient
therapeutic
approaches.
Gels,
Год журнала:
2024,
Номер
10(9), С. 582 - 582
Опубликована: Сен. 9, 2024
The
aim
of
this
study
is
to
develop
a
nanoemulgel
encapsulating
Tunisian
Prickly
Pear
(Opuntia
ficus-indica
L.)
seed
oil
(PPSO)
assess,
for
the
first
time,
in
vivo
efficacy
nanoformulation
on
wound
healing.
Phytocompounds
have
been
reported
literature
as
having
powerful
pharmacological
activities.
However,
it
remains
poorly
exploited
due
low
bioavailability.
A
nanoemulsion
(NE)
was
designed
by
determining
required
hydrophilic–lipophilic
balance
(HLB)
and
subsequently
characterized.
mean
droplet
size
measured
at
56.46
±
1.12
nm,
with
polydispersity
index
(PDI)
0.23
0.01
using
dynamic
light
scattering.
zeta
potential
−31.4
1.4
mV,
morphology
confirmed
assessed
transmission
electron
microscopy
(TEM).
These
characteristics
align
typical
properties
nanoemulsions.
gelification
process
resulted
formation
from
optimum
nanoemulsion.
high
healing
efficiency
compared
that
medicinally
marketed
cream.
outcomes
research
contribute
valuable
insights,
into
therapeutic
applications
PPSO
its
innovative
pharmaceutical
formulation
