ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(28), С. 37007 - 37016
Опубликована: Июль 2, 2024
Osteoblasts
and
osteoclasts
are
two
of
the
most
important
types
cells
in
bone
repair,
their
bone-forming
bone-resorbing
activities
influence
process
repair.
In
this
study,
we
proposed
a
physicochemical
bidirectional
regulation
strategy
via
ration
by
physically
utilizing
hydroxyapatite
nanopatterning
to
recruit
induce
MSCs
osteogenic
differentiation
chemically
inhibiting
osteolysis
activity
through
loaded
zoledronate.
The
nanorod-like
coating
was
fabricated
modified
hydrothermal
while
zoledronic
acid
chelation
within
calcium
ions.
fabrication
hydroxyapatite/zoledronic
composite
biomaterial.
This
biomaterial
promotes
tissue
regeneration
vitro
results
tested
on
RAW
246.7
indicated
that
enhanced
cells'
physical
sensing
system,
therefore
enhancing
osteogenesis.
At
same
time
inhibited
downregulating
RANK-related
genes.
research
provides
promising
for
contributes
field
orthopedic
implants.
Composites Part B Engineering,
Год журнала:
2024,
Номер
280, С. 111455 - 111455
Опубликована: Апрель 23, 2024
The
reconstruction
of
the
vascular
network
is
crucial
step
in
bone
regeneration.
Therefore,
effectively
modulating
angiogenesis-osteogenesis
coupling
tissue
engineering
scaffolds
currently
an
urgent
need.
In
this
study,
we
employed
silane
agents
containing
double
bonds
to
modify
tetrahedral
silicate,
resulting
preparation
a
photocurable
precursor
45S5
bioactive
glass
(PG).
PG
was
utilized
as
binding
agent
for
tricalcium
phosphate
(TCP)
powder,
and
one-step
photocuring
3D
printing
approach
fabricate
PG/TCP
(PT)
scaffolds.
Furthermore,
endothelial
progenitor
cell-derived
exosomes
(EPC-exos)
encapsulated
by
GelMA
anchored
onto
PT
create
exosome-functionalized
PT/G@Exos
composite
summary,
scaffold
orchestrates
creation
vascularized
regeneration
microenvironment
releasing
EPC-exos,
well
calcium,
silicon
(Si),
phosphorus
(P)
elements.
This
enables
efficient
modulation
accelerates
Giant,
Год журнала:
2024,
Номер
19, С. 100298 - 100298
Опубликована: Июнь 3, 2024
The
field
of
bone
regeneration
has
witnessed
significant
advancements
with
the
exploration
and
incorporation
marine
biomaterials,
offering
promising
avenues
for
orthopaedic
dental
applications.
Marine
environments
are
a
rich
source
biological
materials
unique
properties
conducive
to
healing
regeneration.
Repurposing
reusing
some
waste
by-products
products
not
only
contribute
environmental
protection
but
also
drives
development
economy,
thereby
achieving
sustainable
development.
Moreover,
lower
production
costs
associated
abundant
availability
easy
processing
biomaterials
make
therapies
more
accessible
broader
population,
enhancing
global
health
equity.
By
exploring
current
research
progressions
on
recounting
their
sources,
properties,
mechanisms
action,
applications
in
research,
this
review
provides
comprehensive
overview
potential
challenges
future
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
271, С. 132611 - 132611
Опубликована: Май 24, 2024
There
is
a
growing
demand
for
engineered
bone
tissues
custom-designed
to
match
the
patient-specific
defect
size
and
in
vitro
models
studying
diseases
and/or
drug
screening.
Herein,
we
propose
bioprinted
tissue
construct
using
SaOs-2
cells
within
alginate/gellan
gum/hydroxyapatite
inks.
Different
ink
formulations
were
developed
with
varying
hydroxyapatite
content
then
evaluated
viscoelasticity,
printability,
biomineralization
properties,
post-printing
viability,
proliferation,
metabolic
activity,
osteogenic
phenotype
of
SaOs-2-encapsulated
cells.
Results
indicate
that
exhibit
non-Newtonian
shear-thinning
behaviour,
maintaining
shape
integrity
structural
stability
post-printing.
Ink
mineralization
rates
increase
content,
rendering
them
suitable
strategies.
Post-printed
constructs
remain
live,
spreading,
metabolically
active
but
do
not
proliferate.
Osteogenic
gene
protein
expression,
both
early
late,
show
upregulation
at
day
7
relative
1,
followed
by
downregulation
14.
Lower
inks
demonstrate
up
fourfold
genes
proteins
most
time
points.
Additionally,
these
release
calcium
phosphate
levels
conducive
mineralization.
Overall,
tissue-engineered
miniaturized
only
meet
criteria
early-stage
defect/fracture
regeneration
also
serve
as
promising
platform
screening
evaluating
potential
therapeutic
treatments.
Materials & Design,
Год журнала:
2024,
Номер
244, С. 113169 - 113169
Опубликована: Июль 17, 2024
Tendon
injuries
are
very
common
in
orthopedic
practice
and
can
lead
to
constant
pain,
disability,
huge
financial
burden
on
society.
Gelatin
methacrylate
(GelMA)
tendon-derived
stem
cells
(TDSCs)
may
be
helpful
for
the
treatment
of
chronic
micro-injury
disease
tendons.
In
vitro,
GelMA
microspheres
were
physically
evaluated
assessed
their
biological
effects
TDSCs,
including
adhesion,
proliferation,
ability
differentiate
into
tendons,
also
analyzed
by
sequencing
at
RNA
level
validated
relevant
signaling
pathways.
A
rat
Achilles
tendon
microinjury
model
was
used
evaluate
effect
combined
with
TDSCs
repair.
promoted
early
tendinous
differentiation
TDSCs.
able
secrete
large
amounts
extracellular
matrix
activate
RAS/ERK
microenvironment.
vivo,
injection
TDSCs-loaded
repair
microinjury.
synergistically
promote
regeneration
involvement
pathway.
