Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 13, 2024
Piezoelectric
materials,
as
a
class
of
materials
capable
generating
electrical
charges
under
mechanical
vibration,
have
special
piezoelectric
effects
and
been
widely
applied
in
various
disease
treatment
fields.
People
generate
vibrations
the
oral
cavity
during
daily
activities
such
brushing
teeth,
using
electric
toothbrushes,
chewing,
speaking.
These
natural
(or
external
ultrasound)
provide
ideal
conditions
for
activating
leading
to
their
high
potential
applications
protecting
health
treating
diseases.
Based
on
this,
this
review
reports
research
progress
trends
protection
diseases
past
5
years,
discusses
its
mechanism,
challenges
shortcomings,
aiming
theoretical
basis
new
ideas
future
application
field
cavity.
Finally,
brief
outlook
is
provided,
suggesting
that
may
enable
them
quickly
move
towards
real
clinical
applications.
Biosensors,
Год журнала:
2025,
Номер
15(2), С. 100 - 100
Опубликована: Фев. 10, 2025
Understanding
brain
function
requires
advanced
neural
probes
to
monitor
electrical
and
chemical
signaling
across
multiple
timescales
regions.
Microelectrode
arrays
(MEAs)
are
widely
used
record
neurophysiological
activity
various
depths
regions,
providing
single-unit
resolution
for
extended
periods.
Recent
advancements
in
flexible
MEAs,
built
on
micrometer-thick
polymer
substrates,
have
improved
integration
with
tissue
by
mimicking
the
brain's
soft
nature,
reducing
mechanical
trauma
inflammation.
These
flexible,
subcellular-scale
MEAs
can
stable
signals
months,
making
them
ideal
long-term
studies.
In
addition
recording,
been
functionalized
electrochemical
neurotransmitter
detection.
Electroactive
neurotransmitters,
such
as
dopamine,
serotonin,
adenosine,
be
directly
measured
via
methods,
particularly
carbon-based
surfaces.
For
non-electroactive
neurotransmitters
like
acetylcholine,
glutamate,
γ-aminobutyric
acid,
alternative
strategies,
enzyme
immobilization
aptamer-based
recognition,
employed
generate
signals.
This
review
highlights
recent
developments
MEA
fabrication
functionalization
achieve
both
electrophysiological
recordings,
minimizing
sensor
fowling
damage
when
implanted
long-term.
It
covers
multi-time
scale
detection,
development
of
conducting
nanomaterial
composite
coatings
enhance
sensitivity,
incorporation
recognition
carbon
electrodes
MEAs.
Finally,
it
summarizes
strategies
acquire
measurements
from
same
device.
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1041 - 1041
Опубликована: Фев. 25, 2025
Piezoelectric
materials,
due
to
their
ability
generate
an
electric
charge
in
response
mechanical
deformation,
are
becoming
increasingly
attractive
the
engineering
of
bone
and
neural
tissues.
This
manuscript
reports
effects
addition
nanohydroxyapatite
(nHA),
introduction
gold
nanoparticles
(AuNPs)
via
sonochemical
coating,
collector
rotation
speed
on
formation
electroactive
phases
biological
properties
electrospun
nanofiber
scaffolds
consisting
poly(vinylidene
fluoride)
(PVDF).
FTIR,
WAXS,
DSC,
SEM
results
indicate
that
nHA
increases
content
fiber
alignment.
The
rotational
not
only
alignment
but
also
PVDF
PVDF/nHA
fibers.
Increased
orientation
each
additives
resulted
increased
SFE
water
uptake.
In
vitro
tests
conducted
MG-63
hiPSC-NSC
cells
showed
adhesion
cell
proliferation.
PVDF-based
composites
with
AuNPs
promising
candidates
for
development
advanced
tissue
applications,
combining
electrical
functionality
activity
support
regeneration.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Electroactive
platforms
have
gained
significant
attention
for
their
ability
to
convert
various
types
of
energy
into
electrical
signals,
offering
promising
applications
in
diverse
biomedical
fields.
In
cardiovascular
care,
these
are
increasingly
valued
innovative
solutions
managing
cardiac
functions
and
disorders.
By
regulating
activity
the
heart,
electroactive
offer
novel
methods
abnormal
heart
rhythms.
This
review
explores
latest
advancements
systems,
categorizing
them
based
on
sources
mechanisms,
such
as
self‐powered
conductive
systems.
It
also
highlights
arrhythmia
management,
including
monitoring,
intervention,
pacing,
repairing.
Finally,
challenges,
limitations,
future
opportunities
clinical
translation
technologies
discussed.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Severe
bone
and
cartilage
defects
caused
by
trauma
are
challenging
to
treat,
often
resulting
in
poor
outcomes.
An
endogenous
electric
field
(EnEF)
is
crucial
for
regeneration,
making
electrical
materials
a
promising
therapy.
This
review
provides
comprehensive
overview
of
the
role
bioelectric
signals
cells,
alongside
recent
advancements
biomaterials,
with
particular
emphasis
on
nanogenerators,
piezoelectric
materials,
triboelectric
scaffolds,
zwitterionic
hydrogels.
It
further
investigates
impact
these
biomaterials
as
well
applications
both
exogenous
stimulation
(ES)
mechanisms
underlying
ES‐induced
cellular
molecular
responses.
Finally,
underscores
future
directions
ES
systems
tissue
engineering,
emphasizing
critical
importance
integrating
structural
integrity,
mechanical
properties,
signal
delivery
into
intelligent
implantable
scaffolds.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Год журнала:
2025,
Номер
113(4)
Опубликована: Март 17, 2025
ABSTRACT
To
examine
natural
bone's
bioelectrical
traits,
notably
its
piezoelectricity,
and
to
look
into
how
these
characteristics
influence
bone
growth
repair.
In
the
context
of
exploring
potential
piezoelectric
biomaterials,
such
as
biopolymers
bio‐ceramics,
towards
orthopedic
regeneration
applications,
research
seeks
evaluate
significance
piezoelectricity‐driven
osteogenesis.
The
paper
reviews
recent
on
electrical
dielectric
properties,
surface
polarization/electrical
stimulation
effects
interacting
with
cell
activity
effectiveness
biomaterials
support
tissues'
regenerative
process.
study
includes
a
number
materials,
collagen,
polyvinylidene
fluoride
(PVDF)
barium
titanate.
applications
organic
polymers,
polymers
are
particularly
highlighted.
Piezoelectric
being
shown
in
studies
enhance
cellular
metabolism
vitro
well
promote
tissues
vivo,
especially
when
paired
electric
field
or
interface
polarization.
bio‐ceramics
like
magnesium
silicate
titanate,
collagen
PVDF,
have
possibilities
for
applications.
However,
there
several
challenges
regarding
manufacturing
specific
compositions
having
desired
properties.
This
review
highlighted
special
emphasis
bioceramics.
Therefore,
types
materials
huge
because
they
can
mimic
properties
allow
better
advances
tissue
engineering
medicine.
date,
little
is
known
about
their
mechanism
action,
modifications
needed
improve
efficacy
clinical
uptake.
