Nanocrystals in Dermal Drug Delivery: A Breakthrough for Enhanced Skin Penetration and Targeted Skin Disorder Treatments
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1561 - 1561
Опубликована: Дек. 6, 2024
One
of
the
major
challenges
in
dermal
drug
delivery
is
adequate
penetration
active
compound
into
skin
without
causing
any
irritation
and
inflammation.
Nanocrystals
(NCs)
are
nanoscale
particles,
their
sizes
below
1000
nm.
NCs
made
up
particles
only,
which
used
to
improve
aqueous
solubility
bioavailability
poorly
water-soluble
drugs.
typically
prepared
either
by
bottom-up
or
top-down
techniques.
The
advantages
using
NC-based
formulations
enhancing
include
increased
loading
capacity,
easier
deeper
tissue,
passive
diffusion.
with
capacity
enhanced
can
be
effectively
treat
a
wide
range
disorders,
including
melanoma,
inflammation,
psoriasis,
acne
vulgaris,
bacterial
infections,
fungal
eczema,
aging,
herpes
simplex
virus
manifestations
tick
bites,
frostbite-related
hyperpigmentation,
diabetic
foot
ulcer.
In
this
review,
across
barrier,
mechanism
action
NCs,
delivery,
NC
preparation
methods,
applications
treatment
various
disorders
have
been
discussed.
Язык: Английский
Improved Cognitive Impairment Through PLGA Nanocrystal-Based Drug Delivery of Curcumin and Piperine in Alzheimer's Disease Model
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Alzheimer’s
disease
(AD)
is
a
multifactorial
neurodegenerative
that
causes
dementia,
impaired
cognitive
function,
and
disorientation.
Studies
have
revealed
curcumin
piperine
were
found
to
be
neuroprotective
for
patients
with
dementia.
Nevertheless,
both
compounds
are
known
their
poor
solubility.
To
address
issues
related
bioavailability,
nanocrystals
of
in
combination
fabricated
characterized
by
physicochemical,
surface
morphology,
drug
excipient
compatibilities,
bioavailability
studies.
The
nanocrystal
the
highest
was
selected
pharmacokinetics
pharmacodynamics
Optimized
PLGA
co-loaded
(FNC)
successfully
developed
using
emulsion
diffusion-high
pressure
homogenization-solvent
evaporation
(EHS)
technique
Poloxamer
188
as
stabilizer.
Among
nine
formulations,
optimized
FNC1
had
particle
size
116.6
±
2.13
nm
zeta
potential
at
-27.9
1.51
mV.
Saturation
solubility
in
vitro
release
studies
demonstrated
enhanced
compared
pure
compounds.
Oral
administration
streptozotocin
(STZ)-induced
AD
rat
model
presented
significant
improvement
spatial
memory
from
Morris
Water
Maze
Passive
Avoidance
test.
Further
histology
staining
cortex
hippocampus
regions
significantly
reduced
number
pyramidal
cells
extensive
nuclear
pyknosis
degeneration
previously
seen
untreated
STZ-induced
rats.
It
concluded
this
study
improved
which
then
impairment
Язык: Английский
Navigating neurodegeneration: challenges, pathophysiology, biomarkers, and the promise of nanocrystals-based nanotherapeutics
Journal of Microencapsulation,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Май 26, 2025
Approximately
90%
of
drugs
struggle
with
low
solubility
and
non-selectivity
in
target-specific
drug
delivery.
This
creates
a
significant
challenge
due
to
the
limited
permeability
blood-brain
barrier
(BBB)
blood-cerebrospinal
fluid
(CSF)
barrier.
Poor
solubility,
concentration
at
target
site,
rapid
clearance
via
efflux
transporters
further
restrict
effective
delivery
neurodegenerative
disorders
(NDDs).
Nanocrystal
(NC)
technology
offers
promising
approach
by
producing
sub-micron,
carrier-free
NCs
high
payload,
stabilised
stabilisers
enhance
colloidal
stability
shelf
life.
The
increased
surface
area
boosts
bioavailability,
brain
hydrophobic
drugs,
making
an
emerging
for
both
therapeutic
diagnostic
applications
diseases.
are
synthesised
top-down,
bottom-up,
combinational
methods,
NANOEDGE®
SmartCrystals®
being
some
patented
technologies.
Despite
potential
improving
brain,
many
challenges
remain,
including
thermal
instability,
scalability,
long-term
safety.
Язык: Английский
Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1141 - 1141
Опубликована: Авг. 29, 2024
Despite
the
safety
and
convenience
of
oral
administration,
poorly
water-soluble
drugs
compromise
absorption
bioavailability.
These
can
exhibit
low
dissolution
rates,
variability
between
fed
fasted
states,
difficulty
permeating
mucus
layer,
P-glycoprotein
efflux.
Drug
nanocrystals
offer
a
promising
strategy
to
address
these
challenges.
This
review
focuses
on
opportunities
develop
orally
administered
based
pharmacokinetic
outcomes.
The
impacts
drug
particle
size,
morphology,
rate,
crystalline
state
bioavailability
are
discussed.
potential
improved
rate
eliminate
food
effects
during
is
also
addressed.
explores
whether
permeation
or
drives
nanocrystal
absorption.
Additionally,
it
addresses
functional
roles
stabilizers.
may
result
in
prolonged
concentrations
bloodstream
some
cases.
Therefore,
represent
overcome
challenges
drugs,
thus
encouraging
further
investigation
into
unclear
mechanisms
administration.
Язык: Английский