Improved Cognitive Impairment Through PLGA Nanocrystal-Based Drug Delivery of Curcumin and Piperine in Alzheimer's Disease Model
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Abstract
Alzheimer’s
disease
(AD)
is
a
multifactorial
neurodegenerative
that
causes
dementia,
impaired
cognitive
function,
and
disorientation.
Studies
have
revealed
curcumin
piperine
were
found
to
be
neuroprotective
for
patients
with
dementia.
Nevertheless,
both
compounds
are
known
their
poor
solubility.
To
address
issues
related
bioavailability,
nanocrystals
of
in
combination
fabricated
characterized
by
physicochemical,
surface
morphology,
drug
excipient
compatibilities,
bioavailability
studies.
The
nanocrystal
the
highest
was
selected
pharmacokinetics
pharmacodynamics
Optimized
PLGA
co-loaded
(FNC)
successfully
developed
using
emulsion
diffusion-high
pressure
homogenization-solvent
evaporation
(EHS)
technique
Poloxamer
188
as
stabilizer.
Among
nine
formulations,
optimized
FNC1
had
particle
size
116.6
±
2.13
nm
zeta
potential
at
-27.9
1.51
mV.
Saturation
solubility
in
vitro
release
studies
demonstrated
enhanced
compared
pure
compounds.
Oral
administration
streptozotocin
(STZ)-induced
AD
rat
model
presented
significant
improvement
spatial
memory
from
Morris
Water
Maze
Passive
Avoidance
test.
Further
histology
staining
cortex
hippocampus
regions
significantly
reduced
number
pyramidal
cells
extensive
nuclear
pyknosis
degeneration
previously
seen
untreated
STZ-induced
rats.
It
concluded
this
study
improved
which
then
impairment
Language: Английский
Nanocrystals in Dermal Drug Delivery: A Breakthrough for Enhanced Skin Penetration and Targeted Skin Disorder Treatments
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1561 - 1561
Published: Dec. 6, 2024
One
of
the
major
challenges
in
dermal
drug
delivery
is
adequate
penetration
active
compound
into
skin
without
causing
any
irritation
and
inflammation.
Nanocrystals
(NCs)
are
nanoscale
particles,
their
sizes
below
1000
nm.
NCs
made
up
particles
only,
which
used
to
improve
aqueous
solubility
bioavailability
poorly
water-soluble
drugs.
typically
prepared
either
by
bottom-up
or
top-down
techniques.
The
advantages
using
NC-based
formulations
enhancing
include
increased
loading
capacity,
easier
deeper
tissue,
passive
diffusion.
with
capacity
enhanced
can
be
effectively
treat
a
wide
range
disorders,
including
melanoma,
inflammation,
psoriasis,
acne
vulgaris,
bacterial
infections,
fungal
eczema,
aging,
herpes
simplex
virus
manifestations
tick
bites,
frostbite-related
hyperpigmentation,
diabetic
foot
ulcer.
In
this
review,
across
barrier,
mechanism
action
NCs,
delivery,
NC
preparation
methods,
applications
treatment
various
disorders
have
been
discussed.
Language: Английский
Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1141 - 1141
Published: Aug. 29, 2024
Despite
the
safety
and
convenience
of
oral
administration,
poorly
water-soluble
drugs
compromise
absorption
bioavailability.
These
can
exhibit
low
dissolution
rates,
variability
between
fed
fasted
states,
difficulty
permeating
mucus
layer,
P-glycoprotein
efflux.
Drug
nanocrystals
offer
a
promising
strategy
to
address
these
challenges.
This
review
focuses
on
opportunities
develop
orally
administered
based
pharmacokinetic
outcomes.
The
impacts
drug
particle
size,
morphology,
rate,
crystalline
state
bioavailability
are
discussed.
potential
improved
rate
eliminate
food
effects
during
is
also
addressed.
explores
whether
permeation
or
drives
nanocrystal
absorption.
Additionally,
it
addresses
functional
roles
stabilizers.
may
result
in
prolonged
concentrations
bloodstream
some
cases.
Therefore,
represent
overcome
challenges
drugs,
thus
encouraging
further
investigation
into
unclear
mechanisms
administration.
Language: Английский