Cited by Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy

Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

и другие.

Nanomedicine, Год журнала: 2024, Номер 20(3), С. 305 - 318

Опубликована: Дек. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Язык: Английский

Structural characteristics and anti-tumor activity of alkali-extracted acidic polysaccharide extracted from Panax ginseng DOI

Keyao Dai, Chao Liu, Haiyu Ji

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 305, С. 141230 - 141230

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

A Nano-Strategy for Advanced Triple-Negative Breast Cancer Therapy by Regulating Intratumoral Microbiota DOI

Jifan Gao, Lu Tang,

Cong Fu

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Intratumoral microbiota have been identified as a component of the tumor microenvironment that regulates metastatic behavior tumors. They serve not only indicators pathology but also potential drug targets in cancer therapy. Herein, multifunctional nanoplatform (DD@FEL) is prepared by combining antibiotic doxycycline (DOXY) can combat intratumoral and chemotherapeutic doxorubicin (DOX) ergosterol-originated liposome. Specially, ergosterol utilized substitute for cholesterol liposomes to exert pharmacological activity. Mechanistically, DD@FEL leveraged DOXY inhibit metastasis based on regulation microbiota, which synergizes with effect DOX, eventually inhibiting progression triple-negative breast (TNBC). Verified both vitro vivo, effectively exerts cytotoxic TNBC cells, delays growth primary TNBC, attenuates development its lung metastasis, providing promising therapeutic strategy control orthotopic TNBC.

Язык: Английский

Процитировано

Advances in Nanoparticles in Targeted Drug Delivery- A Review DOI