Emergence of magnetic nanoparticles in photothermal and ferroptotic therapies

Materials Horizons, Год журнала: 2023, Номер 10(11), С. 4757 - 4775

Опубликована: Янв. 1, 2023

Magnetic nanoparticles offer versatile opportunities for anti-cancer therapy, stemming from a single metal element, iron, naturally processed by the human body. Applications range magnetic hyperthermia to emerging fields of photothermal therapy and ferroptosis induction.

Язык: Английский

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Carbon-Coated Iron Oxide Nanoparticles Promote Reductive Stress-Mediated Cytotoxic Autophagy in Drug-Induced Senescent Breast Cancer Cells

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(12), С. 15457 - 15478

Опубликована: Март 14, 2024

The surface modification of magnetite nanoparticles (Fe3O4 NPs) is a promising approach to obtaining biocompatible and multifunctional nanoplatforms with numerous applications in biomedicine, for example, fight cancer. However, little known about the effects Fe3O4 NP-associated reductive stress against cancer cells, especially chemotherapy-induced drug-resistant senescent cells. In present study, NPs situ coated by dextran (Fe3O4@Dex) glucosamine-based amorphous carbon coating (Fe3O4@aC) potent activity were characterized tested drug-induced breast cells (Hs 578T, BT-20, MDA-MB-468, MDA-MB-175-VII cells). Fe3O4@aC caused decrease reactive oxygen species (ROS) production an increase levels antioxidant proteins FOXO3a, SOD1, GPX4 that was accompanied elevated cell cycle inhibitors (p21, p27, p57), proinflammatory (NFκB, IL-6, IL-8) autophagic (BECN1, LC3B) markers, nucleolar stress, subsequent apoptotic death etoposide-stimulated also promoted stress-mediated cytotoxicity nonsenescent We postulate NPs, addition their well-established hyperthermia oxidative anticancer effects, can be considered, if modified using activity, as stimulators cytotoxic both different gene mutation statuses.

Язык: Английский

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Magnetoelectrics for biomedical applications: 130 years later, bridging materials, energy, and life

Nano Energy, Год журнала: 2024, Номер 126, С. 109569 - 109569

Опубликована: Апрель 9, 2024

Magnetoelectric (ME) materials have emerged as promising candidates for a wide range of biomedical applications due to their unique ability couple and manipulate both magnetic electric signals. This comprehensive review provides an overview the recent advancements potential MEs in various areas biomedicine. Inspired by Mary Shelley's "Frankenstein," introduction (Section 1) highlights ethical considerations scientific exploration while showcasing benefits ME background human well-being longevity. Then, context, key fundamental concepts are addressed, with special focus on piezoelectric biological tissues that can be sensorized/actuated through 2). Applications related energy supply body 3), sensing 4), other 5) such tissue engineering, cancer therapy, drug delivery, antimicrobial presented, discussed, technologically outlined following sections work. In end, subjective joint opinion is given about advantages, limitations, opportunities, future research directions this 130-year-old field. Can come out technological bridge between energy, life?

Язык: Английский

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Magnetic Nanoparticles: A Comprehensive Review from Synthesis to Biomedical Frontiers

Langmuir, Год журнала: 2024, Номер 40(33), С. 17239 - 17269

Опубликована: Авг. 12, 2024

Nanotechnology has opened new doors of exploration, particularly in materials science and healthcare. Magnetic nanoparticles (MNP), the tiny magnets, because their various properties, have potential to bring about radical changes field medicine. The distinctive surface chemistry, nontoxicity, biocompatibility, and, particular, inducible magnetic moment attracted a great deal interest morphological structures from variety scientific domains. This review presents concise overview MNPs crucial properties synthesis routes. It also aims highlight continuous methods available for MNP production. In recent years, use computational understanding behavior been on rise. Thus, we discuss numerical models developed understand how can be used hyperthermia targeting Circle Wilis. With increasing biomedical applications, it becomes necessary mechanisms toxicity, which are elucidated this review. focuses applications drug delivery, theranostics, MRI contrasting agents. We anticipate that article will broaden perspective help functionality applicability better.

Язык: Английский

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Advances in screening hyperthermic nanomedicines in 3D tumor models

Nanoscale Horizons, Год журнала: 2024, Номер 9(3), С. 334 - 364

Опубликована: Янв. 1, 2024

Integrating the advances of emerging hyperthermia techniques with 3D tumor models and non-invasive temperature control systems can contribute to identifying top-performing hyperthermic nanomedicines in preclinical evaluation stages.

Язык: Английский

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