Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)

Опубликована: Май 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Язык: Английский

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Electrochemical and Photocatalytic Synthesis of Organic Compounds Utilizing a Greener Approach. A review

Molecular Catalysis, Год журнала: 2024, Номер 559, С. 114087 - 114087

Опубликована: Апрель 1, 2024

Язык: Английский

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Iron oxide nanoparticles (Fe3O4, γ-Fe2O3 and FeO) as photothermal heat mediators in the first, second and third biological windows

Physics Reports, Год журнала: 2023, Номер 1043, С. 1 - 35

Опубликована: Ноя. 4, 2023

Nanotherapies are gaining increased interest for the treatment diverse diseases, particularly cancer, since they target affected area directly, presenting higher efficacy and reduced side effects than traditional therapies. A promising nanotherapy approach is hyperthermia, where nanoparticle can induce a local temperature increase by an external stimulus in sick tissue to selectively kill malignant cells. Among hyperthermia methods, photothermia based on absorption of light nanoparticles further conversion into heat. Within very wide range nanostructured photothermal agents, iron oxides offer remarkable features already approved FDA/EMA various biomedical applications, biodegradable, easily manipulated using magnetic fields be imaged techniques. Here, we summarize advantages second biological window, both from perspective skin optical properties oxides. Further, review performance oxide first, third windows. Overall, results show that, different types (Fe3O4, γ-Fe2O3, wüstite-FeO), heating capacity (i.e., induced increase) efficiency, η, vary complex way with wavelength, depending critically measurement conditions physiochemical materials. Despite spread reported oxides, Fe3O4 particles tend perform better their γ-Fe2O3 counterparts, window. Interestingly, FeO, which has not been exploited so far perspective, shows appealing properties. Our preliminary studies FeO/Fe3O4 core/shell evidence that have excellent properties, outperforming first Finally, some applications beyond cancer nanoparticles, exploiting enhanced spectral discussed.

Язык: Английский

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Solvothermally synthesized magnetite nanorods for application in magnetic hyperthermia and photothermia

Journal of Magnetism and Magnetic Materials, Год журнала: 2024, Номер 596, С. 171990 - 171990

Опубликована: Март 26, 2024

Язык: Английский

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Finely tunable NIR‐II organic scaffolds for fluorescence/photoacoustic duplex imaging–guided noninvasive photothermal therapy of glioblastoma

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Окт. 11, 2024

Abstract Organic agents possessing NIR‐II and photoacoustic duplex imaging capabilities, coupled with high‐efficiency photothermal conversion, offer significant potential for noninvasive precise phototheranostics of glioblastoma, which is further augmented when these can concurrently exhibit tumor targeting blood–brain barrier (BBB) permeability. This study reports a series finely tunable molecular luminophores based on the aza‐BODIPY scaffold, featuring unique twisted rotatable structures. They are constructed to folate‐decorated polymeric nanoparticles, exhibiting remarkable NIR‐II/photoacoustic performance superior conversion efficiency (49.7%). Folate modification enables BBB permeability through receptor‐mediated transcytosis, allowing efficient phototherapy in 4T1‐/glioblastoma‐bearing mice after single intravenous injection irradiation. presents rational engineering approach versatile structural scaffold designing emitters tailored photophysical properties desirable phototherapeutic efficacy, thereby offering novel perspectives development advanced depth probes brain therapeutics.

Язык: Английский

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Microneedle-based nanodrugs for tumor immunotherapy

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 539 - 562

Опубликована: Фев. 13, 2025

Язык: Английский

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Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery

Helvetica Chimica Acta, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract Thermoresponsive polymers, which undergo phase transitions within physiologically tolerated temperatures, are key to developing drug delivery systems (DDS) with precise spatial and temporal control, potentially addressing challenges associated the treatment of complex diseases. Inorganic nanoparticles unique optical, electronic, magnetic properties serve as efficient transducers, converting external stimuli into localized heat trigger thermoresponsive nanocarriers. This review explores design application nanocarriers transduced by inorganic DDS. Following a brief description temperature‐triggered transition polymers generation mechanisms nanoparticles, strategies integrate these components hybrid described. Examples demonstrating utility advanced DDS discussed, highlighting their potential for release alongside theranostic capabilities combining therapy imaging. Despite in design, synthesis, biological applications, polymer‐inorganic hybrids hold immense promise transforming biomedical innovations.

Язык: Английский

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Application and advances of multifunctional magnetic nanoparticles in cross-disciplinary research: From design to detection, imaging, and therapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216590 - 216590

Опубликована: Март 4, 2025

Язык: Английский

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Biodegradation by Cancer Cells of Magnetite Nanoflowers with and without Encapsulation in PS-b-PAA Block Copolymer Micelles

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(27), С. 34772 - 34782

Опубликована: Июнь 29, 2024

Magnetomicelles were produced by the self-assembly of magnetite iron oxide nanoflowers and amphiphilic poly(styrene)-b-poly(acrylic acid) block copolymer to deliver a multifunctional theranostic agent. Their bioprocessing cancer cells was investigated in three-dimensional spheroid model over 13-day period compared with nonencapsulated magnetic nanoflowers. A degradation process identified monitored at various scales, exploiting different physicochemical fingerprints. At collective level, measurements conducted using magnetic, photothermal, resonance imaging techniques. nanoscale, transmission electron microscopy employed identify morphological integrity structures, X-ray absorption spectroscopy used analyze crystalline phase chemical levels. All these converge demonstrate that encapsulation nanoparticles micelles effectively mitigates their individual This protective effect consequently resulted better maintenance therapeutic photothermal potential. The structural magnetomicelles occurred through formation an oxidized ferritin from nanoparticles, leaving behind empty spherical polymeric ghost shells. These results underscore significance oxides preserving nanomaterial regulating degradation, even under challenging conditions within cells.

Язык: Английский

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Nanomaterials: leading immunogenic cell death-based cancer therapies

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 9, 2024

The field of oncology has transformed in recent years, with treatments shifting from traditional surgical resection and radiation therapy to more diverse customized approaches, one which is immunotherapy. ICD (immunogenic cell death) belongs a class regulatory death modalities that reactivate the immune response by facilitating interaction between apoptotic cells releasing specific signaling molecules, DAMPs (damage-associated molecular patterns). inducers can elevate expression proteins optimize TME (tumor microenvironment). use nanotechnology shown its unique potential. Nanomaterials, due their tunability, targeting, biocompatibility, have become powerful tools for drug delivery, immunomodulators, etc., significant efficacy clinical trials. In particular, these nanomaterials effectively activate ICD, trigger potent anti-tumor response, maintain long-term tumor suppression. Different types nanomaterials, such as biological membrane-modified nanoparticles, self-assembled nanostructures, metallic mesoporous materials, hydrogels, play respective roles induction structures mechanisms action. Therefore, this review will explore latest advances application common discuss how they provide new strategies cancer therapy. By gaining deeper understanding mechanism action researchers develop precise effective therapeutic approaches improve prognosis quality life patients. Moreover, hold promise overcome resistance conventional therapies, minimize side effects, lead personalized treatment regimens, ultimately benefiting treatment.

Язык: Английский

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