Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 18, 2025
Despite
decades
of
control
efforts,
the
prevalence
schistosomiasis
remains
high
in
many
endemic
regions,
posing
significant
challenges
to
global
health.
One
key
factors
contributing
persistence
disease
is
complex
life
cycle
Schistosoma
parasite,
causative
agent,
which
involves
multiple
stages
development
and
intricate
interactions
with
its
mammalian
hosts
snails.
Among
various
parasite
lifecycle,
deposition
eggs
their
migration
through
host
tissues
significant,
as
they
initiate
onset
pathology
by
inducing
inflammatory
reactions
tissue
damage.
However,
our
understanding
mechanisms
underlying
egg
extravasation
limited,
hindering
efforts
develop
effective
interventions.
Microphysiological
systems,
particularly
organ-on-a-chip
offer
a
promising
approach
study
this
phenomenon
controlled
experimental
setting
because
allow
replication
physiological
microenvironments
vitro.
This
review
provides
an
overview
schistosomiasis,
introduces
concept
technology,
discusses
potential
applications
field
research.
Materials & Design,
Год журнала:
2023,
Номер
226, С. 111661 - 111661
Опубликована: Янв. 27, 2023
Extensive
research
on
nature-inspired
cellular
metamaterials
has
globally
inspired
innovations
using
single
material
and
limited
multifunctionality.
Additive
manufacturing
(AM)
of
intricate
geometries
multi-materials
provides
additional
functionality,
environmental
adaptation,
improved
mechanical
properties.
Recently,
several
studies
have
been
conducted
multi-material
additive
(MMAM)
technologies,
including
multi-materials,
methodologies,
design,
optimization.
However,
in
the
past
six
years,
very
few
or
no
systematic
complete
reviews
this
domain.
This
review
intends
to
comprehensively
summarize
MMAM
systems
working
principles
its
fundamental
processes.
Herein,
Multi-material
combinations
their
modeling,
analysis
strategies
reviewed
systematically.
In
particular,
focus
is
applications
opportunities
for
industries
postprocessing
fabricated
parts.
Furthermore,
identified
limitations
challenges
existing
software
packages,
processes,
materials,
joining
mechanisms,
especially
at
interfaces.
Finally,
we
discuss
possible
overcome
aforementioned
technological
state
future
directions,
which
will
provide
insights
researchers
engineers
designing
complex
objects.
Advanced Materials,
Год журнала:
2023,
Номер
35(26)
Опубликована: Янв. 12, 2023
Abstract
Cartilage
degeneration
is
among
the
fundamental
reasons
behind
disability
and
pain
across
globe.
Numerous
approaches
have
been
employed
to
treat
cartilage
diseases.
Nevertheless,
none
shown
acceptable
outcomes
in
long
run.
In
this
regard,
convergence
of
tissue
engineering
microfabrication
principles
can
allow
developing
more
advanced
microfluidic
technologies,
thus
offering
attractive
alternatives
current
treatments
traditional
constructs
used
applications.
Herein,
developments
involving
hydrogel‐based
scaffolds,
promising
structures
for
regeneration,
ranging
from
hydrogels
with
channels
prepared
by
devices,
that
enable
therapeutic
delivery
cells,
drugs,
growth
factors,
as
well
cartilage‐related
organ‐on‐chips
are
reviewed.
Thereafter,
anatomy
types
damages,
present
treatment
options
briefly
overviewed.
Various
introduced,
advantages
scaffolds
over
thoroughly
discussed.
Furthermore,
available
technologies
fabricating
chips
presented.
The
preclinical
clinical
applications
regeneration
development
time
further
explained.
developments,
recent
key
challenges,
prospects
should
be
considered
so
develop
systems
repair
highlighted.
Microfluidic
technologies
have
been
extensively
investigated
in
recent
years
for
developing
organ-on-a-chip-devices
as
robust
vitro
models
aiming
to
recapitulate
organ
3D
topography
and
its
physicochemical
cues.
Among
these
attempts,
an
important
research
front
has
focused
on
simulating
the
physiology
of
gut,
with
a
distinct
cellular
composition
featuring
plethora
microbial
human
cells
that
mutually
mediate
critical
body
functions.
This
led
innovative
approaches
model
fluid
flow,
mechanical
forces,
oxygen
gradients,
which
are
all
developmental
cues
gut
physiological
system.
A
myriad
studies
demonstrated
gut-on-a-chip
reinforce
prolonged
coculture
microbiota
genotypic
phenotypic
responses
closely
mimic
vivo
data.
Accordingly,
excellent
mimicry
offered
by
gut-on-a-chips
fueled
numerous
investigations
clinical
industrial
applications
devices
years.
In
this
review,
we
outline
various
designs,
particularly
focusing
different
configurations
used
microbiome
intestinal
cells.
We
then
elaborate
adopted
key
physiochemical
stimuli
explore
how
beneficial
understanding
pathophysiology
testing
therapeutic
interventions.
Advances in healthcare information systems and administration book series,
Год журнала:
2024,
Номер
unknown, С. 198 - 219
Опубликована: Фев. 14, 2024
The
organ-on-a-chip
(OOAC)
technology
stands
at
the
forefront
of
emergent
technologies,
representing
a
biomimetic
configuration
functional
organs
on
microfluidic
chip.
This
synergizes
biomedical
engineering,
cell
biology,
and
biomaterial
to
mimic
microenvironment
specific
organs.
It
effectively
replicates
biomechanical
biological
soft
tissue
interfaces,
enabling
simulation
organ
functionality
responses
various
stimuli,
including
drug
reactions
environmental
effects.
OOAC
has
vast
implications
for
precision
medicine
defense
strategies.
In
this
chapter,
authors
delve
into
principles
OOAC,
exploring
its
role
in
creating
physiological
models
discussing
advantages,
current
challenges,
prospects.
examination
is
significant
as
it
highlights
transformative
potential
technologies
21st
century
contributes
deeper
understanding
OOAC's
applications
advancing
medical
research.
Organ-on-chip
(OOC)
systems
are
revolutionizing
tissue
engineering
by
providing
dynamic
models
of
structure,
organ-level
function,
and
disease
phenotypes
using
human
cells.
However,
nonbiological
components
OOC
devices
often
limit
the
recapitulation
in
vivo–like
tissue-tissue
cross-talk
morphogenesis.
Here,
we
engineered
a
kidney
glomerulus-on-a-chip
that
recapitulates
glomerular
morphogenesis
barrier
function
biomimetic
ultrathin
membrane
human-induced
pluripotent
stem
The
resulting
chip
comprised
proximate
epithelial-endothelial
interface,
which
reconstituted
selective
molecular
filtration
healthy
diseased
kidneys.
In
addition,
fenestrated
endothelium
was
successfully
induced
from
cells
an
device,
through
paracrine
signaling
across
membrane.
Thus,
this
device
provides
platform
for
modeling
kidney–specific
enabling
mechanistic
studies
cell
differentiation,
organ
physiology,
pathophysiology.
FEMS Microbiology Reviews,
Год журнала:
2024,
Номер
48(2)
Опубликована: Фев. 26, 2024
Abstract
Bacterial
pneumonia
greatly
contributes
to
the
disease
burden
and
mortality
of
lower
respiratory
tract
infections
among
all
age
groups
risk
profiles.
Therefore,
laboratory
modelling
bacterial
remains
important
for
elucidating
complex
host–pathogen
interactions
determine
drug
efficacy
toxicity.
In
vitro
cell
culture
enables
creation
high-throughput,
specific
models
in
a
tightly
controlled
environment.
Advanced
human
specifically,
can
bridge
research
gap
between
classical
two-dimensional
animal
models.
This
review
provides
an
overview
current
status
development
cellular
study
infections,
with
focus
on
air–liquid
interface
models,
spheroid,
organoid,
lung-on-a-chip
For
wide
scale,
comparative
literature
search,
we
selected
six
clinically
highly
relevant
bacteria
(Pseudomonas
aeruginosa,
Mycoplasma
pneumoniae,
Haemophilus
influenzae,
Mycobacterium
tuberculosis,
Streptococcus
Staphylococcus
aureus).
We
reviewed
lines
that
are
commonly
used,
as
well
trends
discrepancies
methodology,
ranging
from
infection
parameters
assay
read-outs.
also
highlighted
importance
model
validation
data
transparency
guiding
field
towards
more
Biosensors and Bioelectronics X,
Год журнала:
2022,
Номер
11, С. 100194 - 100194
Опубликована: Июль 15, 2022
The
core
of
the
drug
research
and
screening
processes
is
predicting
effect
drugs
prior
to
human
clinical
trials.
Due
2D
cell
culture
animal
models'
poor
predictability,
cost
discovery
continuously
rising.
development
organ-on-a-chip
technology,
an
alternative
traditional
preclinical
testing
models,
resulted
from
intersection
microfabrication
&
tissue
engineering.
Preclinical
safety
effectiveness
improved
by
ability
technologies
mimic
important
physiological
functions
necessary
for
understanding
effects.
Organ-on-a-chip
could
drastically
improve
success
rate
thereby
better
how
will
act
on
a
term
used
describe
microengineered
biomimetic
device
that
mimics
structure
functionality
tissue.
It
integrates
engineering,
biology,
biomaterial
miniature
platform.
To
reflect
physiology
in
vitro
bridge
gap
between
vivo
data,
simplification
shouldn't
compromise
relevance.
At
this
level
technological
development,
biomedical
engineers
specializing
engineering
are
more
than
ever
expedite
transfer
technology
academic
lab
bench
specialized
product
institutions
ever-growing
market.
This
review
focuses
recent
advancements
discusses
potential
based
current
available
literature.
