Microsystems & Nanoengineering,
Год журнала:
2025,
Номер
11(1)
Опубликована: Май 22, 2025
Blood
vessels
are
hierarchical
microchannels
that
transport
nutrients
and
oxygen
to
different
tissues
organs,
while
also
eliminating
metabolic
waste
from
the
body.
Disorders
of
vascular
system
impact
both
physiological
pathological
processes.
Conventional
animal
models
complex,
high-cost,
time-consuming,
low-validity,
which
have
limited
exploration
effective
in
vitro
microsystems.
The
morphologies
micro-scaled
tubular
structures
properties
tissues,
including
mechanical
strength,
thrombogenicity,
immunogenicity,
can
be
mimicked
by
engineering
strategies.
This
review
highlights
state-of-the-art
advanced
strategies
for
microsystems,
covering
domains
related
rational
designs,
manufacturing
approaches,
supporting
materials,
organ-specific
cell
types.
A
broad
range
biomedical
applications
microsystems
summarized,
recent
advances
engineered
vascularized
organs
study,
drug
screening,
personalized
medicine.
Moreover,
commercialization
feasibility
limitations
current
commercially
available
products,
as
well
perspectives
on
future
directions
exploration,
elaborated.
modeling
will
facilitate
rapid,
robust,
efficient
analysis
tissue
broader
regenerative
medicine
towards
development
treatment
approaches.
Advanced Materials,
Год журнала:
2023,
Номер
36(34)
Опубликована: Сен. 22, 2023
Additive
manufacturing
(AM),
which
is
based
on
the
principle
of
layer-by-layer
shaping
and
stacking
discrete
materials,
has
shown
significant
benefits
in
fabrication
complicated
implants
for
tissue
engineering
(TE).
However,
many
native
tissues
exhibit
anisotropic
heterogenous
constructs
with
diverse
components
functions.
Consequently,
replication
biomimetic
using
conventional
AM
processes
a
single
material
challenging.
Multimaterial
3D
4D
bioprinting
(with
time
as
fourth
dimension)
emerged
promising
solution
constructing
multifunctional
that
can
mimic
host
microenvironment
better
than
single-material
alternatives.
Notably,
4D-printed
multimaterial
architectures
provide
time-dependent
programmable
dynamic
promote
cell
activity
regeneration
response
to
external
stimuli.
This
paper
first
presents
typical
design
strategies
TE
applications.
Subsequently,
latest
are
discussed,
along
their
advantages
challenges.
In
particular,
potential
smart
highlighted.
Furthermore,
this
review
provides
insights
into
how
facilitate
realization
next-generation
ACS Sensors,
Год журнала:
2024,
Номер
9(7), С. 3466 - 3488
Опубликована: Июль 11, 2024
Organ-on-a-Chip
(OOC)
technology,
which
emulates
the
physiological
environment
and
functionality
of
human
organs
on
a
microfluidic
chip,
is
undergoing
significant
technological
advancements.
Despite
its
rapid
evolution,
this
technology
also
facing
notable
challenges,
such
as
lack
vascularization,
development
multiorgan-on-a-chip
systems,
replication
body
single
chip.
The
progress
has
played
crucial
role
in
steering
OOC
toward
mimicking
microenvironment,
including
microenvironment
replication,
multiorgan
microphysiological
systems.
Additionally,
advancements
detection,
analysis,
organoid
imaging
technologies
have
enhanced
efficiency
Organs-on-Chips
(OOCs).
In
particular,
integration
artificial
intelligence
revolutionized
imaging,
significantly
enhancing
high-throughput
drug
screening.
Consequently,
review
covers
research
Human-on-a-chip,
sensors
OOCs,
latest
applications
biomedical
field.
Bioactive Materials,
Год журнала:
2024,
Номер
42, С. 140 - 164
Опубликована: Авг. 30, 2024
As
a
powerful
paradigm,
artificial
intelligence
(AI)
is
rapidly
impacting
every
aspect
of
our
day-to-day
life
and
scientific
research
through
interdisciplinary
transformations.
Living
human
organoids
(LOs)
have
great
potential
for
Chinese Medical Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Abstract
The
high
failure
rates
in
clinical
drug
development
based
on
animal
models
highlight
the
urgent
need
for
more
representative
human
biomedical
research.
In
response
to
this
demand,
organoids
and
organ
chips
were
integrated
greater
physiological
relevance
dynamic,
controlled
experimental
conditions.
This
innovative
platform—the
organoids-on-a-chip
technology—shows
great
promise
disease
modeling,
discovery,
personalized
medicine,
attracting
interest
from
researchers,
clinicians,
regulatory
authorities,
industry
stakeholders.
review
traces
evolution
organoids-on-a-chip,
driven
by
necessity
advanced
biological
models.
We
summarize
applications
of
simulating
pathological
phenotypes
therapeutic
evaluation
technology.
section
highlights
how
integrating
technologies
chips,
such
as
microfluidic
systems,
mechanical
stimulation,
sensor
integration,
optimizes
organoid
cell
types,
spatial
structure,
functions,
thereby
expanding
their
applications.
conclude
addressing
current
challenges
offering
insights
into
prospects.
advancement
is
poised
enhance
fidelity,
standardization,
scalability.
Furthermore,
integration
cutting-edge
interdisciplinary
collaborations
will
be
crucial
progression
Human
papillomavirus
(HPV)
is
the
most
common
virus
for
genital
tract
infections.
Cervical
cancer
ranks
as
fourth
prevalent
globally,
with
over
99%
of
cases
in
women
attributed
to
HPV
infection.
This
infection
continues
pose
an
ongoing
threat
public
health.
Therefore,
development
rapid,
high-throughput,
and
sensitive
detection
platforms
important,
especially
regions
limited
access
advanced
medical
resources.
CRISPR-based
biosensors,
a
promising
new
method
nucleic
acid
detection,
are
now
rapidly
widely
used
basic
applied
research
have
received
much
attention
recent
years
diagnosis
treatment.
In
this
review,
we
discuss
mechanisms
functions
CRISPR-Cas
system,
focusing
on
its
applications
diagnostics.
The
review
covers
CRISPR
technologies
such
CRISPR-Cas9,
CRISPR-Cas12,
CRISPR-Cas13,
along
amplification
methods,
signal
output
systems,
point-of-care
testing
(POCT)
strategies.
comprehensive
overview
highlights
versatility
potential
detection.
We
also
numerous
biosensors
developed
since
introduction
detect
HPV.
Finally,
some
challenges
faced
by
system.
Biosensors,
Год журнала:
2023,
Номер
13(10), С. 905 - 905
Опубликована: Сен. 24, 2023
The
increasing
popularity
of
3D
cell
culture
models
is
being
driven
by
the
demand
for
more
in
vivo-like
conditions
with
which
to
study
biochemistry
and
biomechanics
numerous
biological
processes
health
disease.
Spheroids
organoids
are
platforms
that
self-assemble
regenerate
from
stem
cells,
tissue
progenitor
cells
or
lines,
show
great
potential
studying
development
regeneration.
Organ-on-a-chip
approaches
can
be
used
achieve
spatiotemporal
control
over
biochemical
biomechanical
signals
promote
growth
differentiation.
These
model
systems
engineered
serve
as
disease
drug
screens.
While
methods
have
been
developed
support
these
structures,
challenges
remain
completely
recapitulate
cell–cell
cell–matrix
interactions
occurring
vivo.
Understanding
how
forces
influence
functions
will
require
precise
tools
measure
such
forces,
well
a
better
understanding
mechanobiology
interactions.
Biosensors
prove
powerful
measuring
both
contexts,
thereby
leading
mechanical
at
cellular
levels.
Here,
we
discussed
biosensors
mechanobiological
research
coupled
develop
accurate,
physiologically
relevant
development,
function,
malfunction
disease,
avenues
intervention.
