The role of acoustofluidics and microbubble dynamics for therapeutic applications and drug delivery

Biomicrofluidics, Год журнала: 2023, Номер 17(2)

Опубликована: Март 1, 2023

Targeted drug delivery is proposed to reduce the toxic effects of conventional therapeutic methods. For that purpose, nanoparticles are loaded with drugs called nanocarriers and directed toward a specific site. However, biological barriers challenge convey target site effectively. Different targeting strategies nanoparticle designs used overcome these barriers. Ultrasound new, safe, non-invasive method, especially when combined microbubbles. Microbubbles oscillate under effect ultrasound, which increases permeability endothelium, hence, uptake Consequently, this new technique reduces dose avoids its side effects. This review aims describe types critical features acoustically driven microbubbles focusing on biomedical applications. The theoretical part covers historical developments in microbubble models for different conditions: an incompressible compressible medium bubbles encapsulated by shell. current state possible future directions discussed.

Язык: Английский

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Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Applied Sciences, Год журнала: 2023, Номер 13(17), С. 9548 - 9548

Опубликована: Авг. 23, 2023

This concise review delves into the realm of superparamagnetic nanoparticles, specifically focusing on Fe2O3, Mg1+xFe2−2xTixO4, Ni1−xCux, and CrxNi1−x, along with their synthesis methods applications in magnetic hyperthermia. Remarkable advancements have been made controlling size shape these achieved through various techniques such as coprecipitation, mechanical milling, microemulsion, sol–gel synthesis. Through this review, our objective is to present outcomes diverse methods, surface treatment properties, Curie temperature, elucidate impact heating efficiency when subjected high-frequency fields.

Язык: Английский

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Enriching the antimicrobial efficacy of iron oxide with bioderived mesoporous carbon

Inorganic Chemistry Communications, Год журнала: 2024, Номер 161, С. 112111 - 112111

Опубликована: Янв. 23, 2024

Язык: Английский

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Nanohybrid Based on (Mn, Zn) Ferrite Nanoparticles Functionalized With Chitosan and Sodium Alginate for Loading of Curcumin Against Human Breast Cancer Cells

AAPS PharmSciTech, Год журнала: 2023, Номер 24(8)

Опубликована: Ноя. 7, 2023

This study reports on the synthesis of Mn1 - xZnxFe2O4 (Mn, Zn ferrite) magnetic nanoparticles (MNPs) as drug delivery carriers for effective therapeutic outcomes. The MNPs were prepared using coprecipitation method, and their properties investigated based composition. Among compositions tested, Mn0.8Zn0.2Fe2O4 exhibited superparamagnetic with a saturation magnetization moment 34.6 emu/g at room temperature (25°C). To enhance water solubility curcumin (Cur), known its hydrophobic nature, it was successfully loaded onto alginate (Alg)/chitosan (Chit)@Mn0.8Zn0.2Fe2O4 (NPs). nanocomposite characterized by field emission scanning electron microscopy (FE-SEM) which revealed particle size approximately 20 nm. crystalline structure NPs analyzed X-ray diffraction, while Fourier-transform infrared (FTIR), energy-dispersive X-ray, map analysis techniques employed further characterization. In terms release, there an initial burst release Cur (around 18%) within first hour, followed slower (approximately 61%) over next 36 h. anti-tumor Cur-loaded evaluated Methyl Thiazol Tetrazolium (MTT) assay quantitative real-time polymerase chain reaction. MTT confirmed higher cytotoxic effect Alg/[email protected] MCF-7 breast cancer cell line compared to free Cur, highlighting significance incorporating into nano-sized carrier systems.

Язык: Английский

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Cytotoxicity and heating efficiency of dendrimer functionalized graphene oxide modified nickel ferrite nanoparticles

Chemical Physics Letters, Год журнала: 2024, Номер 848, С. 141399 - 141399

Опубликована: Июнь 6, 2024

Язык: Английский

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