The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 25, 2023

Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.

Язык: Английский

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Cell membrane coated-nanoparticles for cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(8), С. 3233 - 3254

Опубликована: Фев. 28, 2022

Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of had positive effects on clinical treatment. However, is still restricted heterogeneity, immune cell disability, tumor immunosuppressive microenvironment systemic toxicity. Cell membrane-coated nanoparticles (CMCNs) inherit abundant source cell-relevant functions, including "self" markers, cross-talking biological targeting, homing to specific regions. These enable them possess preferred characteristics, better compatibility, weak immunogenicity, escaping, a prolonged circulation, targeting. Therefore, they are applied precisely deliver drugs promote effect immunotherapy. In review, we summarize latest researches biomimetic CMCNs for immunotherapy, outline existing therapies, explore unique functions molecular mechanisms various nanoparticles, analyze challenges which face in translation.

Язык: Английский

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Smart drug delivery systems for precise cancer therapy

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(11), С. 4098 - 4121

Опубликована: Авг. 22, 2022

Язык: Английский

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Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

Biomaterials Science, Год журнала: 2022, Номер 10(5), С. 1193 - 1208

Опубликована: Янв. 1, 2022

Macrophage membrane coated nanomaterials are used in various therapies, against infections and inflammation order to combat immune barriers without compromising the efficacy of “cargo” molecules.

Язык: Английский

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Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

Advanced Materials, Год журнала: 2022, Номер 34(30)

Опубликована: Июнь 7, 2022

Osteoarthritis (OA) is a low-grade inflammatory and progressive joint disease, its progression closely associated with an imbalance in M1/M2 synovial macrophages. Repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype emerging as strategy to alleviate OA but compromised by unsatisfactory efficiency. In this study, reprogramming of mitochondrial dysfunction pioneered camouflaged meta-Defensome, which can transform high efficiency 82.3%. The meta-Defensome recognizes activated via receptor-ligand interactions accumulates mitochondria through electrostatic attractions. These meta-Defensomes are macrophage-membrane-coated polymeric nanoparticles decorated dual ligands co-loaded S-methylisothiourea MnO2 . Meta-Defensomes demonstrated successfully reprogram metabolism scavenging reactive oxygen species inhibiting NO synthase, thereby increasing transcription factor A expression restoring aerobic respiration. Furthermore, intravenously injected collagenase-induced osteoarthritis mice effectively suppress inflammation early OA, evident from Research Society International score. Therefore, serve novel practical approach repolarize promising therapeutic agent for impeding tclinic.

Язык: Английский

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Nanovaccines: A game changing approach in the fight against infectious diseases

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115597 - 115597

Опубликована: Сен. 30, 2023

The field of nanotechnology has revolutionised global attempts to prevent, treat, and eradicate infectious diseases in the foreseen future. Nanovaccines have proven be a valuable pawn this novel technology. are made up nanoparticles that associated with or prepared components can stimulate host's immune system. In addition their delivery capabilities, nanocarriers been demonstrated possess intrinsic adjuvant properties, working as cell stimulators. Thus, nanovaccines potential promote rapid well long-lasting humoral cellular immunity. several possible benefits, including site-specific antigen delivery, increased bioavailability, diminished adverse effect profile. To avail these nanoparticle-based vaccines being developed, virus-like particles, liposomes, polymeric nanoparticles, nanogels, lipid emulsion vaccines, exomes, inorganic nanoparticles. Inspired by distinctive researchers on development for variety applications, such cancer immunotherapy diseases. Although few challenges still need overcome, modulation nanoparticle pharmacokinetics avoid elimination from bloodstream reticuloendothelial system, future prospects technology also assuring, multiple options personalised needle-free formulations, combination promising candidates.

Язык: Английский

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Current advances in niosomes applications for drug delivery and cancer treatment

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100837 - 100837

Опубликована: Окт. 21, 2023

The advent of nanotechnology has led to an increased interest in nanocarriers as a drug delivery system that is efficient and safe. There have been many studies addressing nano-scale vesicular systems such liposomes niosome newer generation nanocarriers. niosomes provide multilamellar carrier for lipophilic hydrophilic bioactive substances the self-assembled vesicle, which are composed non-ionic surfactants conjunction with cholesterol or other amphiphilic molecules. These surfactant vesicles, simply known niosomes, can be utilized wide variety technological applications. As alternative liposomes, considered more chemically physically stable. methods preparing economic. Many reports discussed terms their physicochemical properties applications systems. carriers, nano-sized expand horizons pharmacokinetics, decreasing toxicity, enhancing solvability bioavailability. In this review, we review components fabrication well functionalization, characterization, administration routes, cancer gene delivery, natural product delivery. We also discuss limitations challenges development future perspective niosomes.

Язык: Английский

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Hybrid Biomimetic Membrane Coated Particles-Mediated Bacterial Ferroptosis for Acute MRSA Pneumonia

ACS Nano, Год журнала: 2023, Номер 17(12), С. 11692 - 11712

Опубликована: Июнь 13, 2023

Acute methicillin resistant Staphylococcus aureus (MRSA) pneumonia is one of the most frequently seen lung infection diseases with high morbidity and mortality. It urgent to explore an efficient antibacterial strategy owing increase drug resistance, virulence, pathogenicity MRSA. was found that Fe3O4 can induce ferroptosis in MRSA, but its effect inhibited by glutathione (GSH) a certain extent, while cinnamaldehyde (CA) enhance consuming GSH. As bacterial quorum sensing (QS) inhibitor, CA suppress QS system further exert antibiofilm effects. Here, we developed Fe3O4-based inducer promote interrupt QS, destroy biofilm, thus effectively treat acute MRSA pneumonia. We used sodium alginate (SA) wrap form particles, then coated surface hybrid biomimetic membrane composed erythrocyte platelet obtain targeted particles (mFe-CA). Under ultrasonic (US) stimulation, mFe-CA efficiently release CA, thereby synergically inducing death characteristics ferroptosis, including mass ROS production, lipid peroxidation, GSH depletion, respiratory chain suppression. Furthermore, + US inhibit system, remove biofilms, reduce strain virulence. In mouse model pneumonia, treatment markedly advanced survival rate mice, reduced load lungs, alleviated inflammatory damage, there no obvious toxicity. This study proposes substitute which may provide foreground for overcoming microbial resistance fighting biofilm-associated infections also provides target theoretical basis clinical

Язык: Английский

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Engineered mesenchymal stem cell-derived extracellular vesicles: A state-of-the-art multifunctional weapon against Alzheimer's disease

Theranostics, Год журнала: 2023, Номер 13(4), С. 1264 - 1285

Опубликована: Янв. 1, 2023

With the increase of population aging, number Alzheimer's disease (AD) patients is also increasing.According to current estimates, approximately 11% people over 65 suffer from AD, and that percentage rises 42% among 85.However, no effective treatment capable decelerating or stopping AD progression available.Furthermore, AD-targeted drugs composed synthetic molecules pose concerns regarding biodegradation, clearance, immune response, neurotoxicity.Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are essential intercellular communication mediators holding great promise as therapeutics owing their biocompatibility, versatility, effortless storage, superior safety, ability transport messenger noncoding RNAs, proteins, lipids, DNAs, other bioactive compounds derived cells.The functionalisation engineering strategies MSC-EVs highlighted (e.g.preconditioning, drug loading, surface modification, artificial EV fabrication), which could improve by multiple therapeutic effects, including clearing abnormal protein accumulation achieving neuroprotection immunomodulatory effects.Herein, this review summarises state-of-the-art engineer MSC-EVs, discusses progress in use therapeutics, presents perspectives challenges associated with related clinical applications, concludes engineered show immense potential therapy.

Язык: Английский

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