Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Small Methods, Год журнала: 2022, Номер 6(8)

Опубликована: Июнь 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Язык: Английский

---

Exploiting innate immunity for cancer immunotherapy

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Ноя. 27, 2023

Abstract Immunotherapies have revolutionized the treatment paradigms of various types cancers. However, most these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although agents already achieved great success, only a tiny percentage patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined multiple components in tumor microenvironment beyond immunity. Cells innate arm system, such as macrophages, dendritic cells, myeloid-derived suppressor neutrophils, natural killer unconventional also participate cancer evasion surveillance. Considering that cornerstone antitumor response, utilizing immunity provides potential therapeutic options for control. Up to now, exploiting agonists stimulator interferon genes, CAR-macrophage -natural therapies, metabolic regulators, novel exhibited potent activities preclinical clinical studies. Here, we summarize latest insights into roles cells discuss advances arm-targeted strategies.

Язык: Английский

---

Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery

Biomolecules, Год журнала: 2022, Номер 12(5), С. 636 - 636

Опубликована: Апрель 25, 2022

Poly(α-L-glutamic acid) (PGA) is a class of synthetic polypeptides composed the monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non-immunogenicity, PGA-based nanomaterials have been elaborately designed for drug delivery systems. Relevant studies including latest research results on discussed in this work. The following related topics are summarized as: (1) brief description strategies PGAs; (2) an elaborated presentation evolving applications PGA areas delivery, rational design, precise fabrication, biological evaluation; (3) profound discussion further development delivery. In summary, unique structures superior properties enables represent as enormous potential biomaterials-related areas.

Язык: Английский

---

ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

Acta Biomaterialia, Год журнала: 2023, Номер 161, С. 250 - 264

Опубликована: Март 1, 2023

Язык: Английский

---

Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 21, 2024

Abstract Cell membrane‐coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within cell membrane‐derived coating, these combine the advantages of synthetic and natural membranes. This review provides comprehensive overview recent advancements in utilizing CMNPs effective drug delivery vehicles The synthesis fabrication methods are comprehensively discussed. Various techniques, such extrusion, sonication, self‐assembly, employed to coat with membranes derived from different types. membrane coating enables biocompatibility, reducing risk an immune response enhancing stability bloodstream. Moreover, functionalization strategies CMNPs, primarily chemical modification, genetic engineering, external stimuli, highlighted. presence specific surface markers on coated allows targeted cells maximizes efficacy. Preclinical studies therapy demonstrated successful various agents, chemotherapeutic drugs, nucleic acids, immunotherapeutic using CMNPs. Furthermore, article explores future directions challenges this technology while offering insights into its clinical potential.

Язык: Английский

---

The interaction of innate immune and adaptive immune system

MedComm, Год журнала: 2024, Номер 5(10)

Опубликована: Сен. 15, 2024

The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll-like to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific sustained killing via B cells, T antibodies. Traditionally, it has been assumed that activates immunity; however, recent studies have revealed more complex interactions. This review a detailed dissection composition function systems, emphasizing their synergistic roles in physiological pathological contexts, providing new insights into link between these two forms immunity. Precise regulation both systems at same time is beneficial fight against immune-related diseases, for example, cGAS-STING pathway found play an important role infections cancers. In addition, paper summarizes challenges future directions field immunity, including latest single-cell sequencing technologies, CAR-T cell therapy, checkpoint inhibitors. By summarizing developments, aims enhance our understanding complexity interactions perspectives system.

Язык: Английский

---

Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер 20(2), С. 101040 - 101040

Опубликована: Фев. 27, 2025

Cellular hitchhiking is an emerging therapeutic strategy that uses endogenous cell migration mechanism to deliver therapeutics specific sites in the body. Owing low permeability and presence of blood-brain barrier (BBB), targeted delivery limited, leading inadequate localization brain. NCs fail extravasate significantly into tumor microenvironment (TME), demonstrating poor accumulation penetration. The novel cellular concept has been utilized promote systemic half-life targeting. Neoplastic neuroinflammatory diseases brain, including glioblastoma neuroinflammation, face critical hurdles for efficiently delivering entities owing BBB. can surmount these by utilizing various populations, such as stem cells, monocytes/macrophages, neutrophils, platelets, potential functional carriers cargo through These carrier cells have innate capability traverse BBB, transit brain parenchyma, specifically reach disease inflammatory neoplastic lesions chemotactic navigation, i.e., movement attributed chemical stimuli. Chemotherapeutic drugs delivered achieve tumor-specific targeting discussed. This article explores types TME with in-depth mechanisms characterization techniques decipher backpack dissociation dynamics (nanoparticle payload detachment characteristics from hitchhiked cells) challenges toward prospective clinical translation.

Язык: Английский

---

siRNA-Encapsulated Biomimetic Liposomes Effectively Inhibit Tumor Cells’ Hexosamine Biosynthesis Pathway for Attenuating Hyaluronan Barriers to Pancreatic Cancer Chemotherapy

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to excessive hyaluronic acid (HA) accumulation, which impedes drug delivery. Here, we present a targeted approach reduce HA production by specifically silencing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), key enzyme of the hexosamine biosynthesis pathway (HBP) in pancreatic cancer cells. An engineered liposomal system for siGFAT1 delivery, PMLip@siGFAT1, characterized macrophage membrane camouflage, LFC131 peptide-mediated targeting, and calcium phosphate (CaP) as core, was designed ensure prolonged circulation, enhanced inflamed vascular endothelial penetration, subsequent effective tumor cell uptake endosomal escape. Consequently, PMLip@siGFAT1 markedly downregulated level PDAC microenvironment, decompressing vasculature weakening stromal barrier, turn improved permeability chemotherapeutics. In combination with Doxil, demonstrated potent antitumor efficacy minimal systemic toxicity. Importantly, unlike PEGPH20 (hyaluronidase), reduced invasiveness, while preserving skeletal muscle integrity. These findings highlight that holds great potential revitalize downregulation strategies delivery efficacy.

Язык: Английский

---

A brief history of long circulating nanoparticles

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 188, С. 114396 - 114396

Опубликована: Июль 5, 2022

Язык: Английский

---

Core–shell inorganic NP@MOF nanostructures for targeted drug delivery and multimodal imaging-guided combination tumor treatment

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 321, С. 103007 - 103007

Опубликована: Сен. 25, 2023

It is well known that metal-organic-framework (MOF) nanostructures have unique characteristics such as high porosity, large surface areas, and adjustable biofunctionalities, so they are ideal candidates for developing drug delivery systems (DDSs) theranostic platforms in cancer treatment. Despite the number of MOF been discovered, conventional MOF-derived nanosystems only a single biofunctional source poor colloidal stability. Accordingly, it has demonstrated core-shell with good stability useful method generating efficient delivery, multimodal imaging, synergistic therapeutic systems. The preparation done variety materials, but inorganic nanoparticles (NPs) found to be more effective imaging-guided tumor Herein, we aimed overview synthesis NPs@MOF followed by application MOFs derived from magnetic, quantum dots (QDs), gold (Au), gadolinium (Gd) NPs Afterwards, surveyed different factors affecting prolonged therapy, cellular uptake, biocompatibility, biodegradability, enhanced permeation retention (EPR) effect MOFs. Last not least, discussed challenges future prospects field. We envision this article may hold great promise providing valuable insights regarding hybrid promising potential combination therapy.

Язык: Английский

---