Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate

Cells, Год журнала: 2022, Номер 11(9), С. 1375 - 1375

Опубликована: Апрель 19, 2022

Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous structures secreted by cells. They comprised of apoptotic bodies, microvesicles, and exosomes, carry a range nucleic acids proteins that necessary for cell-to-cell communication via interaction on the cells surface. initiate intracellular signaling pathways or transference cargo molecules, which elicit pleiotropic responses in recipient physiological processes, as well pathological such cancer. It is therefore important to understand molecular means EVs taken up into Accordingly, this review summarizes underlying mechanisms involved EV targeting uptake. The primary method entry appears be endocytosis, where clathrin-mediated, caveolae-dependent, macropinocytotic, phagocytotic, raft-mediated uptake have been variously described being prevalent. may depend lipids found surfaces both target As shown contribute cancer growth progression, further exploration gateways utilized internalize tumor assist prevention deceleration pathogenesis.

Язык: Английский

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The in vivo fate of polymeric micelles

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 188, С. 114463 - 114463

Опубликована: Июль 27, 2022

Язык: Английский

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Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies

Theranostics, Год журнала: 2022, Номер 12(3), С. 1030 - 1060

Опубликована: Янв. 1, 2022

Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery distribution of drugs within pancreatic compromised due to intrinsic physical biochemical stresses that lead increased interstitial fluid pressure, vascular compression, hypoxia. Immunotherapy-based approaches, including therapeutic vaccines, immune checkpoint inhibition, CAR-T cell therapy, adoptive T therapies, challenged by an immunosuppressive tumor microenvironment. Together, extensive fibrosis immunosuppression present major challenges developing treatments for cancer. In this context, nanoparticles have been extensively studied as delivery platforms adjuvants cancer other disease therapies. Recent advances in nanotechnology led the development multiple nanocarrier-based formulations not only improve drug but also enhance immunotherapy-based approaches This review discusses critically analyzes novel nanoscale strategies used immunomodulation treatment efficacy, newly emerging approaches. presents important perspectives on future research directions will guide rational design robust treat tumors, particularly with respect targeted therapies immunotherapies. These insights inform next generation clinical help patients manage debilitating survival rates.

Язык: Английский

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Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Controlled release and targeted drug delivery with poly(lactic-co-glycolic acid) nanoparticles: reviewing two decades of research

Journal of Pharmaceutical Investigation, Год журнала: 2022, Номер 52(6), С. 683 - 724

Опубликована: Июль 9, 2022

Язык: Английский

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One-dimensional nanomaterials for cancer therapy and diagnosis

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4488 - 4514

Опубликована: Янв. 1, 2023

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D can be classified according to their shape, such nanorods, nanotubes, nanowires, self-assembled nanochains, etc., have been applied in electronics, photonics, catalysis. The biological characteristics of nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability capture cancer cells, cellular uptake mechanisms, efficient photothermal conversion, material tunability, aided extending potential biomedical applications, particularly therapy diagnosis. This review highlights a novel perspective on emerging diagnosis by introducing definition physicochemical properties, recent advances also proposes unexplored nanomaterial types therapeutic applications nanomaterials. In particular, most significant exciting years, ultrasound-enabled sonodynamic therapy, magnetic field-based bioresponsive intracellular self-assembly situ, discussed along with concepts, piezoelectric nanozyme-based nanomedicine, others.

Язык: Английский

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Polycaprolactone and its derivatives for drug delivery

Polymers for Advanced Technologies, Год журнала: 2023, Номер 34(10), С. 3296 - 3316

Опубликована: Июль 14, 2023

Abstract Polycaprolactone (PCL) is polymer of 21st centuries. PCL a biodegradable and biocompatible used for various healthcare applications. This review explores the properties, synthesis, processing PCL. The use nanoparticles (NPs), microparticles, films, fibers offers several advantages biomedical highlights potential PCL‐based materials tissue engineering, drug delivery, wound healing, implantable medical devices. We also critically analyzed challenges in strategies to overcome successful translation into clinical Overall, this provides comprehensive overview as valuable biomaterial

Язык: Английский

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Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115130 - 115130

Опубликована: Окт. 31, 2023

Язык: Английский

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Multifunctional nanoparticles for image-guided drug delivery in nuclear medicine: advancements and applications

Journal of Radioanalytical and Nuclear Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

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Hydrophobic Chitosan Derivatives for Gene and Drug Delivery in Cancer Therapies

Polysaccharides, Год журнала: 2025, Номер 6(1), С. 11 - 11

Опубликована: Фев. 5, 2025

Chitosan remains one of the most widely used biopolymers in biomedicine due to its non-toxicity and biodegradability. It is easily chemically modified, allowing properties be effectively altered improve performance as a gene drug carrier. The introduction hydrophobic moieties into chitosan can significantly enhance interaction with cancer cells, improving potential for targeted delivery. moiety plays crucial role particle cell membrane during internalization by endocytosis. type moiety, degree substitution, placement along backbone all influence physicochemical biological resulting polymer. Hydrophobic modification also affect self-assembly behavior chitosan, influencing size, shape, stability particles. These factors impact loading efficiency therapeutic agents release kinetics encapsulated cargo. While efficacy it important consider toxic effects. In summary, powerful strategy By understanding cellular uptake, endosomal escape, self-assembly, toxicity, researchers design develop optimized chitosan-based delivery systems therapy.

Язык: Английский

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