International Immunopharmacology, Год журнала: 2024, Номер 129, С. 111659 - 111659
Опубликована: Фев. 12, 2024
Язык: Английский
Theranostics, Год журнала: 2023, Номер 13(12), С. 4138 - 4165
Опубликована: Янв. 1, 2023
Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within affected regions.Reliable biomarkers that can accurately reflect disease activity, diagnose, monitor progression neurodegenerative crucial for development effective therapies.However, identifying suitable has been challenging due to heterogeneous nature these diseases, affecting specific subsets in brain regions.One promising approach promoting regeneration recovery involves transplantation mesenchymal stem cells (MSCs).MSCs have demonstrated ability modulate immune system, promote neurite outgrowth, stimulate angiogenesis, repair damaged tissues, partially through release their extracellular vesicles (EVs).MSC-derived EVs retain some therapeutic characteristics parent MSCs, including regulate facilitate tissue repair.This review aims explore potential MSC-derived as an emerging strategy highlighting role modulating neuronal recovery.By elucidating mechanisms which exert effects, we advance our understanding leverage novel treatment approaches field diseases.
Язык: Английский
Процитировано
66
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 28, 2024
Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although current tumor treatment methods have therapeutic effect to certain extent, they still some shortcomings such as poor water solubility, short half-life, local systemic toxicity. Therefore, how deliver agent so realize safe effective anti-tumor therapy become urgently be solved in this field. As medium of information exchange material transport between cells, exosomes are considered promising drug delivery carrier due their nano-size, good biocompatibility, natural targeting, easy modification. In review, we summarize recent advances isolation, identification, loading, modification carriers for alongside application therapy. Basic knowledge exosomes, biogenesis, sources, characterization methods, also introduced herein. addition, challenges related use vehicles discussed, along with future trends. This review provides scientific basis exosome systems oncological
Язык: Английский
Процитировано
41
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 3, 2024
Abstract Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed a lipid bilayer membrane containing various biologically active cargoes such as proteins, lipids, nucleic acids. Engineered exosomes generated through genetic modification of parent show promise drug delivery vehicles, they have been demonstrated to great therapeutic potential for treating cancer, cardiovascular, neurological, immune diseases, but systematic knowledge is lacking regarding optimization loading assessment efficacy. This review summarizes current approaches engineering evaluating their effects, techniques assessing exosome release kinetics, cell targeting, biodistribution, pharmacokinetics, outcomes critically examined. Additionally, this synthesizes the latest applications in clinical translation. The compiled provides framework rational design rigorous therapeutics. Continued advancement robust characterization methods reporting standards will accelerate development technologies pave way studies. Graphical
Язык: Английский
Процитировано
37
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1205 - 1205
Опубликована: Янв. 18, 2024
Extracellular vesicles (EVs), comprising exosomes and microvesicles, are small membranous structures secreted by nearly all cell types. They have emerged as crucial mediators in intercellular communication, playing pivotal roles diverse physiological pathological processes, notably within the realm of immunity. These go beyond mere cellular interactions, extracellular stand versatile dynamic components immune regulation, impacting both innate adaptive Their multifaceted involvement includes activation, antigen presentation, immunomodulation, emphasising their significance maintaining homeostasis contributing to pathogenesis immune-related disorders. participate immunomodulation delivering a wide array bioactive molecules, including proteins, lipids, nucleic acids, thereby influencing gene expression target cells. This manuscript presents comprehensive review that encompasses vitro vivo studies aimed at elucidating mechanisms through which EVs modulate human Understanding intricate interplay between immunity is imperative for unveiling novel therapeutic targets diagnostic tools applicable various immunological disorders, autoimmune diseases, infectious cancer. Furthermore, recognising potential drug delivery vehicles holds significant promise future immunotherapies.
Язык: Английский
Процитировано
27
Journal of Extracellular Vesicles, Год журнала: 2024, Номер 13(7)
Опубликована: Июль 1, 2024
Abstract Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste disposal vesicle but an essential part of intercellular communication system. Besides the use EVs in biomarker studies and diagnostics, potential EV‐therapeutics been seen by many. They provide unique properties for disease therapy, including strong immune‐modulatory actions, possibility engineering, low immunogenicity, capability crossing biological barriers. Proof‐of‐concept various pathologies achieved preclinical studies. However, clinical trials with have only emerging slowly. Here, we aim to comprehensive overview current state‐of‐the‐art concerning using human therapy. By approaching knowledge systematic manner, were able include 21 reports meta‐analysis safety evaluation efficacy outcomes. Overall, shown EV‐based therapy is safe incidence serious adverse events (SAE; 0.7% (95%‐CI: 0.1–5.2%), (AE; 4.4% 0.7–22.2%). Subgroup analysis showed no significant difference SAE when comparing autologous versus allogeneic administration, as well engineered non‐engineered EV products. A significantly higher number AE was administration. relevance remains questionable. Evaluation outcomes immunostimulatory, immunosuppressive or regenerative EV‐therapies indicated improvement majority treated patients. Despite these promising results, data need be approached caution due high heterogeneity manufacturing methods, study design, reporting (S)AE. conclude presents opportunity More efforts needed standardization harmonization isolation characterization (S)AE allow inter‐study comparison.
Язык: Английский
Процитировано
25
Pharmaceutics, Год журнала: 2023, Номер 15(8), С. 2070 - 2070
Опубликована: Авг. 1, 2023
Exosomes are nanoscale vesicles released by diverse types of cells for complex intercellular communication. Numerous studies have shown that exosomes can regulate the body’s immune response to tumor and interfere with microenvironment (TME). In clinical trials on dendritic cell (DC)-based antitumor vaccines, no satisfactory results been achieved. However, recent suggested DC-derived (DEXs) may be superior DC-based vaccines in avoiding cell-mediated immunosuppression. DEXs contain multiple surface markers capture tumor-associated antigens (TAAs) promote cell-dependent rejection. These findings indicate necessity further development improvement DEX-based cell-free complement chemotherapy, radiotherapy, other immunotherapies. this review, we highlighted progress cancer immunotherapy, particularly concentrating landmark biological characterization DEXs, summarized their important role (TIME) application targeted immunotherapy. This review could enhance comprehension advances immunotherapy contribute elucidation how TIME, thereby providing a reference utilizing practice.
Язык: Английский
Процитировано
33
Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)
Опубликована: Авг. 14, 2023
Acute myocardial infarction has long been the leading cause of death in coronary heart disease, which is characterized by irreversible cardiomyocyte and restricted blood supply. Conventional reperfusion therapy can further aggravate injury. Stem cell therapy, especially with mesenchymal stem cells (MSCs), emerged as a promising approach to promote cardiac repair improve function. MSCs may induce these effects secreting exosomes containing therapeutically active RNA, proteins lipids. Notably, normal function depends on intracardiac paracrine signaling via exosomes, secreted partially reflect changes during so analyzing vesicles provide valuable insights into pathology well guide development new treatments. The present review examines how produced influence injury after serve therapies against such Video Abstract.
Язык: Английский
Процитировано
29
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 17, 2023
Exosomes are extracellular vesicles (EVs) containing various ingredients such as DNA, RNA, lipids and proteins, which play a significant role in intercellular communication. Numerous studies have demonstrated the important of exosomes bone regeneration through promoting expression osteogenic-related genes proteins mesenchymal stem cells. However, low targeting ability short circulating half-life limited their clinical application. In order to solve those problems, different delivery systems biological scaffolds been developed. Hydrogel is kind absorbable scaffold composed three-dimensional hydrophilic polymers. It not only has excellent biocompatibility superior mechanical strength but can also provide suitable nutrient environment for growth endogenous Thus, combination between hydrogels improve stability maintain activity while achieving sustained release defect sites. As an component matrix (ECM), hyaluronic acid (HA) plays critical physiological pathological processes cell differentiation, proliferation, migration, inflammation, angiogenesis, tissue regeneration, wound healing cancer. recent years, acid-based used exosome system displayed positive effects. This review mainly summarized potential mechanism HA application prospects challenges devices regeneration.
Язык: Английский
Процитировано
22
The Science of The Total Environment, Год журнала: 2024, Номер 925, С. 171774 - 171774
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
14
Journal of Oral Biosciences, Год журнала: 2024, Номер 66(2), С. 288 - 299
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
10