Neurotoxicity Following Exposure to Micro and Nanoplastics

OBM Neurobiology, Год журнала: 2025, Номер 09(01), С. 1 - 20

Опубликована: Март 16, 2025

The pervasive presence and enduring existence of micro nanoplastics in the environment render their exposure to humans aquatic creatures unavoidable. Research indicates these tiny plastic particles can be taken by beings mammals. Once within body, have capability infiltrate brain, although level penetration subsequent neurotoxic effects are not fully explored. Previous studies indicate that metal (oxide) nanoparticles enter brain induce effects. Given chemical resemblances between inert nanoparticles, this review aims summarize existing on implications across various species vitro settings. current evidence, incomplete, suggests may lead oxidative stress, potentially causing cell damage raising risk developing neurological disorders. Moreover, such could inhibit acetylcholinesterase activity alter neurotransmitter levels, contributing observed behavioral changes. There is a notable lack systematic comparison regarding stemming from different particle types, shapes, sizes at concentrations durations exposure. Understanding aspects essential for further evaluating danger associated with nanoplastics.

Язык: Английский

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New Advances in Biomedical Application of Polymeric Micelles

Pharmaceutics, Год журнала: 2022, Номер 14(8), С. 1700 - 1700

Опубликована: Авг. 15, 2022

In the last decade, nanomedicine has arisen as an emergent area of medicine, which studies nanometric systems, namely polymeric micelles (PMs), that increase solubility and stability encapsulated drugs. Furthermore, their application in dermal drug delivery is also relevant. PMs present unique characteristics because core-shell architecture. They are colloidal dispersions amphiphilic compounds, self-assemble aqueous medium, giving a structure-type core-shell, with hydrophobic core (that can encapsulate drugs), hydrophilic shell, works stabilizing agent. These features offer adequate steric protection determine hydrophilicity, charge, length, surface density properties. due to small size, be absorbed by intestinal mucosa drug, they transport bloodstream until therapeutic target. Moreover, improve pharmacokinetic profile high load capacity, synthesized reproducible, easy, low-cost method. silico approaches have been explored physicochemical properties PMs. Based on this, computer-aided strategy was developed validated enable poorly soluble drugs established critical parameters maximize loading, formulation stability, tumor exposure. Poly(2-oxazoline) (POx)-based display unprecedented loading concerning water-insoluble over 60 incorporated POx Among various stimuli, pH temperature most widely studied for enhanced release at site action. Researchers focusing dual (pH temperature) responsive controlled improved systems mainly evaluated cancer therapy certain malignancies cause slight decrease extracellular around site. This review compilation updated applications PMs, such based Pluronics®, micelleplexes Pox-based several biomedical applications.

Язык: Английский

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Synthesis and Application of MOF-808 Decorated with Folic Acid-Conjugated Chitosan as a Strong Nanocarrier for the Targeted Drug Delivery of Quercetin

Inorganic Chemistry, Год журнала: 2022, Номер 61(48), С. 19354 - 19368

Опубликована: Ноя. 16, 2022

Herein, MOF-808 (MOF = metal-organic framework) based on zirconium tricarboxylate was synthesized to investigate the influence of decorating groups folic acid-conjugated chitosan (CS-FA) drug-delivery efficiency. Quercetin (QU) loaded nondecorated and then decorated with a acid-chitosan conjugate. The properties activities modified were compared unmodified MOF-808. QU@MOF-808@CS-FA exhibited favorable drug-release properties, high drug-loading capacity, efficient targeting capability, pH-dependent release behavior, highlighting critical role organic modification. A variety characterization techniques used characterize MOF nanoparticles, including Fourier transform infrared, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray, transmission Brunauer-Emmett-Teller, ζ potential, 1H NMR. Additionally, Monte Carlo simulation calculations carried out examine interactions between structures QU. An in vitro cytotoxicity test conducted, results identified that demonstrated more superior therapeutics than QU@MOF-808 FR-positive MCF7 cancerous cells. On basis results, is promising drug carrier by selective sustained release.

Язык: Английский

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Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review

Particle and Fibre Toxicology, Год журнала: 2023, Номер 20(1)

Опубликована: Янв. 5, 2023

Abstract Background Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) stressor, which defines the perturbation in system (molecular initiating event, MIE), dependent series key (KEs), ending an adverse (AO). AOPs have recently become subject intense studies view to better understand mechanisms nanomaterial (NM) toxicity. Silver nanoparticles (Ag NPs) one most explored nanostructures extensively used various application. This, turn, has increased potential for Ag NPs environments, human health. The aim this study was construct putative (pAOP) related reproductive NPs, order lay groundwork comprehension affecting both undesired (against cell) expected microorganisms). Methods PubMed Scopus were systematically searched peer-reviewed examining NPs. quality selected assessed through ToxRTool. Eventually, forty-eight published between 2005 2022 identify impact on function male. endpoints, measurements, results extracted from these studies. Where possible, endpoints assigned KE AO using expert judgment. Then, KEs classified at each major level organization. Results We identified impairment intracellular SH-containing biomolecules, cellular antioxidants, as MIE, subsequent defined ROS accumulation, mitochondrial damage, DNA damage lipid peroxidation, apoptosis, reduced production hormones sperm. These successive may result impaired male fertility Conclusion This research recapitulates schematically represents complex literature data gathered different levels propose pAOP induced by AgNPs. development specific NMs should be encouraged provide new insights gain understanding NP

Язык: Английский

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A pH-responsive bi-MIL-88B MOF coated with folic acid-conjugated chitosan as a promising nanocarrier for targeted drug delivery of 5-Fluorouracil

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 6, 2023

Cancer has remained one of the leading causes death worldwide, with a lack effective treatment. The intrinsic shortcomings conventional therapeutics regarding tumor specificity and non-specific toxicity prompt us to look for alternative mitigate these limitations. In this regard, we developed multifunctional bimetallic (FeCo) bi-MIL-88B-FC MOFs modified folic acid-conjugated chitosan (FC) as drug delivery systems (DDS) targeted 5-Fluorouracil (5-FU). bi-MIL-88B nanocarriers were characterized through various techniques, including powder X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, thermogravimetric analysis, Fourier transform infrared spectroscopy. Interestingly, 5-FU@bi-MIL-88B-FC showed slower release 5-FU due gated effect phenomenon endowed by FC surface coating compared un-modified 5-FU@bi-MIL-88B. pH-responsive was observed, 58% loaded released in cancer cells mimicking pH (5.2) only 24.9% under physiological (5.4). vitro cytotoxicity cellular internalization experiments revealed superiority highly potent DDS against folate receptor (FR) positive SW480 cells. Moreover, presence Fe Co structure, exhibited peroxidase-like activity chemodynamic therapy. Based on results, could serve promising candidate smart sustained selective targeting.

Язык: Английский

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Functionalized Metal Nanoparticles in Cancer Therapy

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1932 - 1932

Опубликована: Июль 11, 2023

Currently, there are many studies on the application of nanotechnology in therapy. Metallic nanoparticles promising nanomaterials cancer therapy; however, functionalization these with biomolecules has become relevant as their effect cells is considerably increased by photothermal and photodynamic therapies, drug nanocarriers, specificity antibodies, resulting new therapies that more specific against different types cancer. This review describes functionalized palladium, gold, silver platinum treatment cancer, themselves show an anticancer effect. further enhanced when NPs either DNA, RNA, peptides, proteins, or folic acid other molecules. These can penetrate cell accumulate tumor tissue, a cytotoxic through generation ROS, induction apoptosis, cycle arrest, DNA fragmentation, NP-based therapy strategy be used synergistically chemotherapy radiotherapy to achieve effective reduce side effects.

Язык: Английский

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Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity

Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2406 - 2406

Опубликована: Сен. 30, 2023

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.

Язык: Английский

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Tetrahedral framework nucleic acids’ role in facilitating chronic diabetic wound repair via the endoplasmic reticulum-mitochondrial pathway

Nano Today, Год журнала: 2024, Номер 56, С. 102252 - 102252

Опубликована: Апрель 1, 2024

Язык: Английский

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Hyaluronic acid-oleylamine and chitosan-oleic acid conjugate-based hybrid nanoparticle delivery via. dissolving microneedles for enhanced treatment efficacy in localized breast cancer

Biomaterials Advances, Год журнала: 2024, Номер 160, С. 213865 - 213865

Опубликована: Апрель 18, 2024

Язык: Английский

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Polymeric nanocarriers delivery systems in ischemic stroke for targeted therapeutic strategies

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 18, 2024

Abstract Ischemic stroke is a complex, high-mortality disease with multifactorial etiology and pathogenesis. Currently, drug therapy mainly used treat ischemic in clinic, but there are still some limitations, such as limited blood-brain barrier (BBB) penetration efficiency, narrow treatment time window side effects. Recent studies have pointed out that delivery systems based on polymeric nanocarriers can effectively improve the insufficient for stroke. They provide neuronal protection by extending plasma half-life of drugs, enhancing drug’s permeability to penetrate BBB, targeting specific structures cells. In this review, we classified delivering drugs introduced their preparation methods. We also evaluated feasibility effectiveness discussed existing limitations prospects treatment. hoped review could theoretical basis future development nanomedicine Graphical

Язык: Английский

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