Effect of molecular weight of chitosan on the physicochemical, morphological, and biological properties of polyplex nanoparticles intended for gene delivery DOI
María E. Aranda-Barradas,

Saul E. Trejo-López,

Alicia Del Real

и другие.

Carbohydrate Polymer Technologies and Applications, Год журнала: 2022, Номер 4, С. 100228 - 100228

Опубликована: Июнь 14, 2022

Язык: Английский

Cationic and anionic PLGA-cholesterol hybrid nanoparticles as promising platforms to enhance the trypanocidal efficacy of benznidazole and drug delivery in Trypanosoma cruzi-infected cells DOI Open Access
Thayse Silva Medeiros,

Lucas Eduardo Bezerra de Lima,

Eron Lincoln Alves-Pereira

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117782 - 117782

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1
Inhalable Nano Formulation of Cabazitaxel: A Comparative Study with Intravenous Route DOI Creative Commons
Elif Kağa, Sadık Kağa,

Korhan Altunbas

и другие.

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Abstract Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, pulmonary (INH) route choice for inhalable formulations. In study, biochemical and histological parameters Cabazitaxel (CBZ) free (2 mg kg −1 ) nanoparticle (NP) CBZ equivalent) formulations are investigated after IV INH rats. The nanoformulation obtained using PEGylated polystyrene (PEG‐PST) nanoparticles PISA. While a nose head‐only device used administration, jugular vein as route. Blood samples (blank, 24 h, 48 h) collected via carotid artery cannulas without handling metabolism cages. According to parameters, formulation applied or shows toxicity. On hand, showed no signs toxicity both Higher longer retention observed inhaled nanoformulation. Histological analysis alveolar macrophage migration due enhanced retention. Results that nanotechnology defense system gave advantage end up with an nanomedicine cancer.

Язык: Английский

Процитировано

1
The uptake of extracellular vesicles: research progress in cancer drug resistance and beyond DOI

Luomeng Qian,

Pangzhou Chen,

Shiwu Zhang

и другие.

Drug Resistance Updates, Год журнала: 2025, Номер 79, С. 101209 - 101209

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment DOI Creative Commons

Yonglong He,

Wanting Zhang,

Qingqing Xiao

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2022, Номер 17(6), С. 817 - 837

Опубликована: Ноя. 1, 2022

The liposome is the first nanomedicine transformed into market and applied to human patients. Since then, such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds biological drugs. Numerous investigations about uses were conducted different treatment fields, including anti-tumor, anti-fungal, anti-bacterial, clinical analgesia, owing liposome's ability reduce drug cytotoxicity improve therapeutic efficacy combinatorial delivery. In particular, two liposomal vaccines approved 2021 combat COVID-19. Herein, clinically used liposomes are reviewed by introducing various preparations detail that currently proceeding clinic or on market. Finally, we discuss challenges of developing cutting-edge delivery for drugs combination therapy.

Язык: Английский

Процитировано

37
Effect of molecular weight of chitosan on the physicochemical, morphological, and biological properties of polyplex nanoparticles intended for gene delivery DOI
María E. Aranda-Barradas,

Saul E. Trejo-López,

Alicia Del Real

и другие.

Carbohydrate Polymer Technologies and Applications, Год журнала: 2022, Номер 4, С. 100228 - 100228

Опубликована: Июнь 14, 2022

Язык: Английский

Процитировано

31