Polymers,
Год журнала:
2023,
Номер
15(18), С. 3759 - 3759
Опубликована: Сен. 14, 2023
Chitosan
is
obtained
from
the
deacetylation
of
chitin,
and
it
known
to
possess
antimicrobial
activity.
It
has
attracted
attention
as
may
be
used
for
treating
infections
caused
by
different
types
microorganisms
due
its
broad
spectrum.
Its
application
in
form
micro-
or
nanoparticles
(CM/CN)
expanded
usage,
this
form,
retains
activity,
remain
stable
aqueous
solutions.
However,
inconsistencies
results
reported
authors
have
been
identified.
In
communication,
activity
CN
produced
starting
materials
was
tested
against
Listeria
monocytogenes.
observed
that,
even
though
all
were
a
molecular
weight
(MW)
below
200
kDa
degree
(DD)
>
75%,
size
CNs
significantly
(263
nm
vs.
607
nm).
Furthermore,
these
differences
sizes
exerted
direct
effect
on
properties
particles,
when
testing
ones
with
smallest
size,
i.e.,
263
nm,
lower
Minimum
Inhibitory
Concentration
(MIC)
achieved,
0.04
mg/mL.
Even
largest
individual
experiments
able
achieve
an
MIC
0.03
mg/mL,
presented
great
variation
among
replicates
up
0.2
mg/mL
needed
other
replicates.
The
material
critical
impact
CN,
must
carefully
characterized
selected
intended
application,
MW
DD
solely
do
not
fully
account
properties.
Pharmaceutics,
Год журнала:
2024,
Номер
16(7), С. 868 - 868
Опубликована: Июнь 27, 2024
Gene
therapy
involves
the
introduction
of
exogenous
genetic
material
into
host
tissues
to
modify
gene
expression
or
cellular
properties
for
therapeutic
purposes.
Initially
developed
address
disorders,
has
expanded
encompass
a
wide
range
conditions,
notably
cancer.
Effective
delivery
nucleic
acids
target
cells
relies
on
carriers,
with
non-viral
systems
gaining
prominence
due
their
enhanced
safety
profile
compared
viral
vectors.
Chitosan,
biopolymer,
is
frequently
utilized
fabricate
nanoparticles
various
biomedical
applications,
particularly
acid
delivery,
recent
emphasis
targeting
cancer
cells.
Chitosan’s
positively
charged
amino
groups
enable
formation
stable
nanocomplexes
and
facilitate
interaction
cell
membranes,
thereby
promoting
uptake.
Despite
these
advantages,
chitosan-based
face
challenges
such
as
poor
solubility
at
physiological
pH,
non-specificity
cells,
inefficient
endosomal
escape,
limiting
transfection
efficiency.
To
limitations,
researchers
have
focused
enhancing
functionality
chitosan
nanoparticles.
Strategies
include
improving
stability,
specificity,
increasing
uptake
efficiency,
escape.
This
review
critically
evaluates
formulation
approaches
within
categories,
aiming
provide
insights
advancing
improved
efficacy,
in
therapy.
Polymers,
Год журнала:
2023,
Номер
15(10), С. 2244 - 2244
Опубликована: Май 9, 2023
Edible
films
were
produced
by
combining
a
pectin
(PEC)
matrix
with
chitosan
nanopar-ticle
(CSNP),
polysorbate
80
(T80),
and
garlic
essential
oil
(GEO)
as
an
antimicrobial
agent.
CSNPs
analyzed
for
their
size
stability,
the
films,
throughout
contact
angle,
scanning
electron
microscopy
(SEM),
mechanical
thermal
properties,
water
vapor
transmission
rate,
activity.
Four
filming-forming
suspensions
investigated:
PGEO
(control);
PGEO@T80;
PGEO@CSNP;
PGEO@T80@CSNP.
The
compositions
are
included
in
methodology.
average
particle
was
317
nm,
zeta
potential
reaching
+21.4
mV,
which
indicated
colloidal
stability.
angle
of
exhibited
values
65°,
43°,
78°,
64°,
respec-tively.
These
showed
variations
hydrophilicity.
In
tests,
containing
GEO
inhibition
only
S.
aureus.
For
E.
coli,
occurred
CSNP
direct
culture.
results
indicate
promising
al-ternative
designing
stable
nanoparticles
application
novel
food
packaging.
Although,
it
still
shows
some
deficiencies
demonstrated
elongation
data.
Polymer-Plastics Technology and Materials,
Год журнала:
2023,
Номер
62(16), С. 2182 - 2220
Опубликована: Сен. 3, 2023
ABSTRACTChitosan,
a
biocompatible
and
nontoxic
heteropolymer
derived
from
chitin,
offers
various
applications.
However,
its
limited
solubility
above
pH
6.5
hinders
broader
Chemical,
physical,
enzymatic
modifications
have
greatly
improved
chitosan
properties,
producing
water-soluble
(WSC)
derivatives.
WSC
derivatives
possess
unique
structures,
water
solubility,
meeting
the
demands
of
functional
materials.
This
review
highlights
native
characteristics,
modification
strategies
for
emphasizes
applications
in
food
production,
wastewater
treatment,
biomedical,
agriculture.
Future
perspectives
are
also
discussed
at
end
this
paper.KEYWORDS:
Biological
propertiesbiopolymerChitinchitosanmaterial
synthesiswater
Disclosure
statementNo
potential
conflict
interest
was
reported
by
author(s).Additional
informationFundingThe
authors
grateful
financial
support
Ministry
Higher
Education
(MOE)
Malaysia
supporting
project
under
Fundamental
Research
Grant
Scheme
(FRGS)
(FRGS/1/2018/STG01/USM/02/14).
In
addition,
we
thank
The
IPTA
Academic
Training
(SLAI)
Universiti
Sarawak
that
sponsored
first
author.Notes
on
contributorsWan
Roslina
Wan
YusofWan
Yusof
received
her
Bachelor
Degree
Biochemistry
(2008)
Kebangsaan
(UKM).
2012,
she
awarded
with
Master
Science
Chemical
Pathology
Sains
(USM).
Currently,
is
doctorate
student
working
nanoparticles
control
plant
fungal
infections
supervision
Dr.
Sumiyyah
Sabar
Professor
Awang
Ahmad
Sallehin
Husaini.Nur
Yusra
Farzana
AwangNur
Industrial
Technology
(2021)
Islam
(USIM).
pursuing
Material
Chemistry
(USM),
Dr
Juzaili
Azizi.Muhammad
Affuwan
Azhar
LaileMuhammad
Laile
his
Applied
University
MARA
(UiTM).
At
moment
he
(USM)
Fatehah
Omar.
He
currently
development
as
biocoagulant
treatment.Juzaili
AziziJuzaili
Azizi
serves
senior
lecturer
Centre
Drug
Research,
2008,
obtained
Bachelor's
degree
Malaya
(UM)
followed
Master's
Pharmacology
2011.
successfully
completed
Ph.D.
King's
College
London
2018.
His
expertise
blood-brain
barrier
(BBB),
drug
delivery
to
brain
neuroprotection
Parkinson's
disease.Awang
HusainiDr.
Husaini
Enzymology
Molecular
Biology
Faculty
Resource
Technology,
Sarawak.
graduated
majoring
Microbiology
Putra
Malaysia,
PhD
Biomolecular
Sciences
Manchester.
research
interests
focus
use
application
beneficial
microbes
their
enzymes
developing
green
technology
such
valorization
agricultural
waste
high
value
added
platform
chemicals,
bioremediation
hazardous
pollutants,
biofertilizer
biocontrol
sustainable
practices.Azman
SeeniDr.
Md
Azman
Seeni
Mohamed
Director
Center
Innovation
Biomedical
SIRIM
Berhad.
Associate
Advanced
Medical
Dental
Institute,
USM
15
years
has
been
secondment
National
Institute
Biotechnology
(NIBM)
Acting
Executive
Malaysian
Pharmaceuticals
Nutraceuticals
3
years.
over
20
years'
experience
Cancer
published
numerous
paper
High
Impact
Factor.
So
far,
supervised
more
than
40
postgraduate
students
cancer
well
biomaterial
products.
won
many
prestigious
awards
either
local
or
international
competition
e.g.
American
Association
Travel
Award
2009,
Double
Gold
British
Invention
Show
2011
one
patent
chemo
preventive
agent.
Recently,
focused
work
Chemoprevention
using
nanotechnology.Lee
D.
WilsonDr.
Lee
Wilson
an
Indigenous
scholar
who
B.Sc.
Winnipeg,
Saskatchewan,
later
PDF
training
NSERC
Visiting
Fellow
Steacie
(National
Council
Canada,
Ottawa,
Canada).
holds
appointment
professor
Department
Saskatchewan.
chemistry
biopolymers
biomaterials
relate
studies
aimed
understanding
structure-function
relationships
carbohydrate
polymers
sorption
phenomena
diverse
processes.
group
actively
involved
characterization
structure
physicochemical
properties.
aims
tools
methods
address
range
fundamental
scientific
questions
practical
problems
relevant
water,
food,
energy
security
sustainability.Sumiyyah
SabarDr.
Senior
Lecturer
Programme
School
Distance
Education,
Her
area
fields
environmental,
material,
chemistry.
She
Analytical
Environmental
Terengganu
(UMT)
2007
Photocatalysis
2013.
subsequently
joined
USM,
2018,
pursued
one-year
postdoctoral
study
Singapore
(NUS),
Singapore.
Sumiyyah's
current
focuses
visible
light
active
photocatalysts,
polysaccharide-based
biopolymers,
adsorption
regeneration
spent
adsorbents,
microextraction
methods.
Drug Delivery and Translational Research,
Год журнала:
2023,
Номер
14(4), С. 895 - 917
Опубликована: Окт. 16, 2023
Abstract
Hesperidin
(Hsd),
a
bioactive
phytomedicine,
experienced
an
antidiabetic
activity
versus
both
Type
1
and
2
Diabetes
mellitus
.
However,
its
intrinsic
poor
solubility
bioavailability
is
key
challenging
obstacle
reflecting
oral
delivery.
From
such
perspective,
the
purpose
of
current
study
was
to
prepare
evaluate
Hsd-loaded
sulfobutylether-β-cyclodextrin/chitosan
nanoparticles
(Hsd/CD/CS
NPs)
for
improving
hypoglycemic
orally
administered
Hsd.
Hsd
first
complexed
with
sulfobutylether-β-cyclodextrin
(SBE-β-CD)
complex
(CX)
found
be
formed
percent
complexation
efficiency
process
50.53
±
1.46
84.52
3.16%,
respectively.
Also,
solid
state
characterization
ensured
inclusion
inside
cavity
SBE-β-CD.
Then,
Hsd/CD/CS
NPs
were
prepared
using
ionic
gelation
technique.
The
fully
characterized
select
most
promising
one
(F1)
homogenous
particle
size
455.7
9.04
nm,
positive
zeta
potential
+
32.28
1.12
mV,
entrapment
77.46
0.39%.
optimal
formula
subjected
further
investigation
in
vitro
release,
ex
vivo
intestinal
permeation,
stability,
cytotoxicity,
activity.
results
release
permeation
studies
F1
manifested
modulated
pattern
between
CX.
preferential
stability
observed
at
4
°C.
biocompatibility
epithelial
cell
line
(OEC)
retained
up
concentration
100
µg/mL.
After
administration
F1,
noteworthy
synergistic
effect
recorded
decreased
blood
glucose
level
until
end
experiment.
In
conclusion,
could
regarded
as
hopeful
delivery
system
enhanced
Graphical
