Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 22, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
with
multifactorial
etiology
and
intricate
pathogenesis.
In
RA,
repeated
monotherapy
frequently
associated
inadequate
efficacy,
drug
resistance,
severe
side
effects.
Therefore,
a
shift
has
occurred
in
clinical
practice
toward
combination
therapy.
However,
conventional
therapy
encounters
several
hindrances,
including
low
selectivity
to
arthritic
joints,
short
half-lives,
varying
pharmacokinetics
among
coupled
drugs.
Emerging
nanotechnology
offers
incomparable
opportunity
for
developing
advanced
against
RA.
First,
it
allows
co-delivering
multiple
drugs
augmented
physicochemical
properties,
targeted
delivery
capabilities,
controlled
release
profiles.
Second,
enables
therapeutic
nanomaterials
development,
thereby
expanding
regimens
include
multifunctional
nanomedicines.
Lastly,
facilitates
the
construction
of
all-in-one
nanoplatforms
assembled
modalities,
such
as
phototherapy,
sonodynamic
therapy,
imaging.
Thus,
promising
solution
current
bottleneck
both
RA
treatment
diagnosis.
This
review
summarizes
rationale,
advantages,
recent
advances
nano-empowered
It
also
discusses
safety
considerations,
drug–drug
interactions,
potential
translation.
Additionally,
provides
design
tips
outlook
on
future
developments
The
objective
this
achieve
comprehensive
understanding
mechanisms
underlying
unlock
maximum
nanotechnology,
facilitating
smooth
transition
research
findings
from
laboratory
practice.
Pharmaceutics,
Год журнала:
2022,
Номер
14(3), С. 540 - 540
Опубликована: Фев. 28, 2022
Rheumatoid
arthritis
(RA)
and
osteoarthritis
(OA)
are
disabling
musculoskeletal
disorders
that
affect
joints
cartilage
may
lead
to
bone
degeneration.
Conventional
delivery
of
anti-arthritic
agents
is
limited
due
short
intra-articular
half-life
toxicities.
Innovations
in
polymer
chemistry
have
led
advancements
hydrogel
technology,
offering
a
versatile
drug
platform
exhibiting
tissue-like
properties
with
tunable
loading
high
residence
time
This
review
discusses
the
advantages
drawbacks
polymeric
materials
along
their
modifications
as
well
applications
for
fabricating
hydrogels
loaded
therapeutic
(small
molecule
drugs,
immunotherapeutic
agents,
cells).
Emphasis
given
biological
potentialities
hybrid
systems/micro-and
nanotechnology-integrated
promising
tools.
Applications
facile
tuning
loading,
maintaining
long-term
release,
consequently
improving
outcome
patient
compliance
detailed.
also
suggests
advantages,
challenges,
future
perspectives
potential
alter
landscape
currently
available
treatment
modalities.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1772 - 1772
Опубликована: Июнь 20, 2023
Chronic
inflammation
contributes
to
the
pathogenesis
of
many
diseases,
including
apparently
unrelated
conditions
such
as
metabolic
disorders,
cardiovascular
neurodegenerative
osteoporosis,
and
tumors,
but
use
conventional
anti-inflammatory
drugs
treat
these
diseases
is
generally
not
very
effective
given
their
adverse
effects.
In
addition,
some
alternative
medications,
natural
compounds,
have
scarce
solubility
stability,
which
are
associated
with
low
bioavailability.
Therefore,
encapsulation
within
nanoparticles
(NPs)
may
represent
an
strategy
enhance
pharmacological
properties
bioactive
molecules,
poly
lactic-co-glycolic
acid
(PLGA)
NPs
been
widely
used
because
high
biocompatibility
biodegradability
possibility
finely
tune
erosion
time,
hydrophilic/hydrophobic
nature,
mechanical
by
acting
on
polymer's
composition
preparation
technique.
Many
studies
focused
PLGA-NPs
deliver
immunosuppressive
treatments
for
autoimmune
allergic
or
elicit
protective
immune
responses,
in
vaccination
cancer
immunotherapy.
By
contrast,
this
review
PLGA
preclinical
vivo
models
other
a
key
role
played
chronic
unbalance
between
reparative
phases
inflammation,
particular
focus
intestinal
bowel
disease;
cardiovascular,
neurodegenerative,
osteoarticular,
ocular
diseases;
wound
healing.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 22, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
with
multifactorial
etiology
and
intricate
pathogenesis.
In
RA,
repeated
monotherapy
frequently
associated
inadequate
efficacy,
drug
resistance,
severe
side
effects.
Therefore,
a
shift
has
occurred
in
clinical
practice
toward
combination
therapy.
However,
conventional
therapy
encounters
several
hindrances,
including
low
selectivity
to
arthritic
joints,
short
half-lives,
varying
pharmacokinetics
among
coupled
drugs.
Emerging
nanotechnology
offers
incomparable
opportunity
for
developing
advanced
against
RA.
First,
it
allows
co-delivering
multiple
drugs
augmented
physicochemical
properties,
targeted
delivery
capabilities,
controlled
release
profiles.
Second,
enables
therapeutic
nanomaterials
development,
thereby
expanding
regimens
include
multifunctional
nanomedicines.
Lastly,
facilitates
the
construction
of
all-in-one
nanoplatforms
assembled
modalities,
such
as
phototherapy,
sonodynamic
therapy,
imaging.
Thus,
promising
solution
current
bottleneck
both
RA
treatment
diagnosis.
This
review
summarizes
rationale,
advantages,
recent
advances
nano-empowered
It
also
discusses
safety
considerations,
drug–drug
interactions,
potential
translation.
Additionally,
provides
design
tips
outlook
on
future
developments
The
objective
this
achieve
comprehensive
understanding
mechanisms
underlying
unlock
maximum
nanotechnology,
facilitating
smooth
transition
research
findings
from
laboratory
practice.
