Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Nanovaccines: A game changing approach in the fight against infectious diseases

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115597 - 115597

Опубликована: Сен. 30, 2023

The field of nanotechnology has revolutionised global attempts to prevent, treat, and eradicate infectious diseases in the foreseen future. Nanovaccines have proven be a valuable pawn this novel technology. are made up nanoparticles that associated with or prepared components can stimulate host's immune system. In addition their delivery capabilities, nanocarriers been demonstrated possess intrinsic adjuvant properties, working as cell stimulators. Thus, nanovaccines potential promote rapid well long-lasting humoral cellular immunity. several possible benefits, including site-specific antigen delivery, increased bioavailability, diminished adverse effect profile. To avail these nanoparticle-based vaccines being developed, virus-like particles, liposomes, polymeric nanoparticles, nanogels, lipid emulsion vaccines, exomes, inorganic nanoparticles. Inspired by distinctive researchers on development for variety applications, such cancer immunotherapy diseases. Although few challenges still need overcome, modulation nanoparticle pharmacokinetics avoid elimination from bloodstream reticuloendothelial system, future prospects technology also assuring, multiple options personalised needle-free formulations, combination promising candidates.

Язык: Английский

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Application of PLGA as a Biodegradable and Biocompatible Polymer for Pulmonary Delivery of Drugs

AAPS PharmSciTech, Год журнала: 2023, Номер 24(1)

Опубликована: Янв. 18, 2023

Язык: Английский

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Acute lung injury caused by sepsis: how does it happen?

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Ноя. 21, 2023

Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple organs, among which the lung most susceptible, leaving patients highly vulnerable to acute injury (ALI). Refractory hypoxemia and respiratory distress are classic clinical symptoms of ALI sepsis, has mortality rate 40%. Despite extensive research on mechanisms exact pathological process not fully understood. This article reviews advances in pathogenesis sepsis focusing treatment regimens adopted practice for corresponding molecular mechanisms. review can only contribute theories but also recommend new strategies related injuries.

Язык: Английский

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Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 25, 2024

Abstract Sepsis, a prevalent critical condition in clinics, continues to be the leading cause of death from infections and global healthcare issue. Among organs susceptible harmful effects sepsis, lungs are notably most frequently affected. Consequently, patients with sepsis predisposed developing acute lung injury (ALI), severe cases, respiratory distress syndrome (ARDS). Nevertheless, precise mechanisms associated onset ALI/ARDS remain elusive. In recent years, there has been growing emphasis on role endothelial cells (ECs), cell type integral barrier function, their interactions various stromal sepsis-induced ALI/ARDS. this comprehensive review, we summarize involvement intricate interplay immune cells, including pulmonary epithelial fibroblasts, pathogenesis ALI/ARDS, particular placed discussing several pivotal pathways implicated process. Furthermore, discuss potential therapeutic interventions for modulating functions relevant present strategy managing

Язык: Английский

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Tunable rigidity of PLGA shell-lipid core nanoparticles for enhanced pulmonary siRNA delivery in 2D and 3D lung cancer cell models

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 746 - 760

Опубликована: Янв. 20, 2024

Язык: Английский

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Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors

Biotechnology Advances, Год журнала: 2025, Номер 81, С. 108546 - 108546

Опубликована: Фев. 26, 2025

Язык: Английский

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Lipid carriers for mRNA delivery

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 13(10), С. 4105 - 4126

Опубликована: Ноя. 30, 2022

Messenger RNA (mRNA) is the template for protein biosynthesis and emerging as an essential active molecule to combat various diseases, including viral infection cancer. Especially, mRNA-based vaccines, a new type of vaccine, have played leading role in fighting against current global pandemic COVID-19. However, inherent drawbacks, large size, negative charge, instability, hinder its use therapeutic agent. Lipid carriers are distinguishable promising vehicles mRNA delivery, owning capacity encapsulate deliver negatively charged drugs targeted tissues release cargoes at desired time. Here, we first summarized structure properties different lipid carriers, such liposomes, liposome-like nanoparticles, solid lipid-polymer hybrid nanoemulsions, exosomes lipoprotein particles, their applications delivering mRNA. Then, development lipid-based formulations vaccine delivery systems was discussed highlighted. Recent advancements COVID-19 were emphasized. Finally, described our future vision perspectives this field.

Язык: Английский

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Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

Journal of Controlled Release, Год журнала: 2022, Номер 352, С. 970 - 993

Опубликована: Ноя. 16, 2022

Язык: Английский

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Nebulization of extracellular vesicles: A promising small RNA delivery approach for lung diseases

Journal of Controlled Release, Год журнала: 2022, Номер 352, С. 556 - 569

Опубликована: Ноя. 3, 2022

Язык: Английский

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