Journal of Molecular and Cellular Cardiology, Год журнала: 2022, Номер 173, С. 141 - 153
Опубликована: Окт. 20, 2022
Язык: Английский
Molecular Biomedicine, Год журнала: 2023, Номер 4(1)
Опубликована: Окт. 16, 2023
Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.
Язык: Английский
Процитировано
69
Cell Host & Microbe, Год журнала: 2023, Номер 31(5), С. 766 - 780.e7
Опубликована: Апрель 25, 2023
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The impact the gut microbiota and associated metabolites on APAP function remains unclear. We show that disturbance with distinct microbial community, notable decreases in Lactobacillus vaginalis. Mice receiving L. vaginalis showed resistance to hepatotoxicity due liberation isoflavone daidzein from diet by bacterial β-galactosidase. hepatoprotective effects APAP-exposed germ-free mice were abolished β-galactosidase inhibitor. Similarly, β-galactosidase-deficient produced poorer outcomes APAP-treated than wild-type strain, but these differences overcome administration. Mechanistically, prevented ferroptotic death, which was linked decreased expression farnesyl diphosphate synthase (Fdps) activated key ferroptosis pathway involving AKT-GSK3β-Nrf2. Thus, inhibits Fdps-mediated hepatocyte ferroptosis, providing promising therapeutic approaches for DILI.
Язык: Английский
Процитировано
67
Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102201 - 102201
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
49
Redox Biology, Год журнала: 2023, Номер 69, С. 102987 - 102987
Опубликована: Дек. 7, 2023
Micheliolide (MCL), which is the active metabolite of parthenolide, has demonstrated promising clinical application potential. However, effects and underlying mechanisms MCL on atherosclerosis are still unclear.
Язык: Английский
Процитировано
45
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Апрель 2, 2024
Abstract Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, cleavage peptide off fibronectin III domain-containing 5, has been shown to preserve cardiac function ischemia–reperfusion injury. Whether or not irisin plays cardioprotective role DCM known. Methods and results T1DM was induced by multiple low-dose intraperitoneal injections of streptozotocin (STZ). Our current study showed that expression/level lower the heart serum mice STZ-induced TIDM. Irisin supplementation injection improved impaired DCM, ascribed inhibition ferroptosis, because increased associated malondialdehyde (MDA), decreased reduced glutathione (GSH) protein expressions solute carrier family 7 member 11 (SLC7A11) peroxidase 4 (GPX4), ameliorated irisin. In presence erastin, ferroptosis inducer, irisin-mediated protective effects were blocked. Mechanistically, treatment Sirtuin (SIRT1) p53 K382 acetylation, expression increasing its degradation, consequently upregulated SLC7A11 GPX4 expressions. Thus, reduction decreases protects cardiomyocytes against injury due high glucose. Conclusion This demonstrated could improve suppressing via SIRT1-p53-SLC7A11/GPX4 pathway. may be therapeutic approach management T1DM-induced cardiomyopathy.
Язык: Английский
Процитировано
32
Antioxidants, Год журнала: 2024, Номер 13(4), С. 484 - 484
Опубликована: Апрель 18, 2024
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation
Язык: Английский
Процитировано
32
Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)
Опубликована: Март 21, 2024
Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved
Язык: Английский
Процитировано
24
Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(6), С. 100930 - 100930
Опубликована: Янв. 3, 2024
Non-communicable diseases (NCDs), including cardiovascular diseases, cancer, metabolic and skeletal pose significant challenges to public health worldwide. The complex pathogenesis of these is closely linked oxidative stress inflammatory damage. Nuclear factor erythroid 2-related 2 (Nrf2), a critical transcription factor, plays an important role in regulating antioxidant anti-inflammatory responses protect the cells from damage inflammation-mediated injury. Therefore, Nrf2-targeting therapies hold promise for preventing treating NCDs. Quercetin (Que) widely available flavonoid that has properties. It modulates Nrf2 signaling pathway ameliorate inflammation. Que mitochondrial function, apoptosis, autophagy, cell biomarkers regulate inflammation, highlighting its efficacy as therapeutic agent against Here, we discussed, first time, close association between NCD pathway, involved neurodegenerative disease, cancers, organ damage, bone Furthermore, reviewed availability, pharmacokinetics, pharmaceutics, applications In addition, focused on prospects clinical use. represents promising candidate treatment NCDs due
Язык: Английский
Процитировано
22
Pharmacological Research, Год журнала: 2024, Номер 200, С. 107057 - 107057
Опубликована: Янв. 11, 2024
Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial and DCM; however, its effects on mitophagy remain unexplored. The present study aimed to assess the beneficial of nicorandil DCM underlying mechanisms. Cardiac perfusion was assessed using a lectin assay, while via mt-Keima transfection transmission electron microscopy. Ferroptosis examined mRNA sequencing, fluorescence staining, western blotting. localization Parkin, ACSL4, AMPK determined immunofluorescence staining. Following long-term diabetes, treatment improved function remodeling by alleviating injuries, as evidenced structural integrity. mRNA-sequencing biochemical analyses showed that occurred Pink1/Parkin-dependent suppressed cells after diabetes. Nicorandil mitochondria-associated promoting mitophagy. Moreover, increased phosphorylation level AMPKα1 promoted translocation, which further inhibited translocation ACSL4 ultimately ferroptosis. Importantly, overexpression mitochondria-localized (mitoAα1) shared similar benefits with mitophagy, cardiovascular protection injury. In conclusion, demonstrated therapeutic revealed AMPK-Parkin-ACSL4 signaling pathway mediates development dysfunction.
Язык: Английский
Процитировано
20
Antioxidants, Год журнала: 2024, Номер 13(2), С. 147 - 147
Опубликована: Янв. 25, 2024
Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly disease prevention and treatment. SFN proven to be effective combating different types of cancer by inhibiting the proliferation tumors triggering apoptosis. This dual action demonstrated result reduction tumor size an enhancement survival rates animal models. also shown antidiabetic anti-obesity effects, improving glucose tolerance reducing fat accumulation. SFN’s ability activate Nrf2, transcription factor regulating oxidative stress inflammation cells, primary mechanism behind anticancerogenic effects. Its antioxidant, anti-inflammatory, anti-apoptotic properties are suggested provide beneficial effects against neurodegenerative diseases. The benefits have led increased interest use as dietary supplement or adjunct chemotherapy, but there insufficient data on efficacy optimal doses, well safety. review aims present discuss treating various diseases, such cancer, diabetes, cardiovascular obesity, focusing mechanisms action. It summarizes studies pharmacological toxicological vitro models explores protective role toxic compounds through studies.
Язык: Английский
Процитировано
20