Bioengineering,
Год журнала:
2022,
Номер
9(7), С. 294 - 294
Опубликована: Июнь 30, 2022
Currently,
breast-cancer
treatment
has
a
number
of
adverse
side
effects
and
is
associated
with
poor
rates
progression-free
survival.
Therefore,
radiolabeled
anti-EpCAM
targeted
biomimetic
coated
nanocarrier
(EINP)
was
developed
in
this
study
to
overcome
some
the
challenges.
The
double
emulsion
method
synthesized
poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticle
Na131I
entrapped
core.
PLGA
human
red
blood
cell
membranes
labeled
epithelial
adhesion
molecule
(EpCAM)
antibody
enable
it
target
EpCAM
overexpression
by
cells.
Characterization
determined
EINP
size
as
295
nm,
zeta
potential
−35.9
mV,
polydispersity
0.297.
radiochemical
purity
>95%.
Results
efficacy
against
positive
MCF-7
breast
cancer
at
24,
48,
72
h
were
69.11%,
77.84%,
74.6%,
respectively,
demonstrating
that
EINPs
achieved
greater
cytotoxic
supported
NIS-mediated
uptake
than
non-targeted
131INPs
Na131I.
In
comparison,
fibroblast
(EpCAM
negative)
treated
had
significantly
lower
cytotoxicity
(p
<
0.05).
Flow
cytometry
fluorescence
imaging
visually
signified
delivery
specifically
cells
result
targeting.
Additionally,
favorable
safety
profile,
hemolysis.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(8)
Опубликована: Май 31, 2024
Immune
dysregulation
is
a
pivotal
factor
in
the
onset
and
progression
of
various
diseases.
In
cancer,
immune
system's
inability
to
discern
eliminate
abnormal
cells
leads
uncontrolled
tumor
growth.
When
faced
with
resilient
pathogens
or
harmful
toxins,
system
encounters
challenges
clearance
neutralization.
Achieving
delicate
balance
pro‐inflammatory
anti‐inflammatory
signals
essential
managing
range
disorders
Like
other
biomedical
research
domains,
nanotechnology
has
provided
innovative
approaches
for
rebalancing
host
immunity.
Among
plethora
nanotechnology‐based
interventions,
concept
cell
membrane‐coated
nanoparticles
holds
significant
potential
immunomodulatory
applications
owing
their
biomimetic
properties
that
allow
precise
interaction
compromised
system.
This
review
thoroughly
examines
novel
nanosystems
modulation.
The
exploration
covers
crucial
elements,
including
origins
characteristics
membranes,
methods
employed
procurement
coating,
physicochemical/biological
characterization
techniques,
enhancement
therapeutic
efficacy
via
functionalization.
Subsequently,
case
studies‐based
analysis
utilizing
these
bioinspired
tackling
different
conditions
caused
by
disturbance
been
comprehensively
discussed.
Nanomaterials,
Год журнала:
2024,
Номер
14(5), С. 413 - 413
Опубликована: Фев. 23, 2024
Recent
strides
in
nanomaterials
science
have
paved
the
way
for
creation
of
reliable,
effective,
highly
accurate,
and
user-friendly
biomedical
systems.
Pioneering
integration
natural
cell
membranes
into
sophisticated
nanocarrier
architectures,
membrane
camouflage
has
emerged
as
a
transformative
approach
regulated
drug
delivery,
offering
benefits
minimal
immunogenicity
coupled
with
active
targeting
capabilities.
Nevertheless,
utility
such
is
curtailed
by
challenges
like
suboptimal
precision
lackluster
therapeutic
efficacy.
Tailored
engineering
stands
at
forefront
biomedicine,
equipping
nanoplatforms
capacity
to
conduct
more
complex
operations.
This
review
commences
an
examination
prevailing
methodologies
engineering,
spotlighting
strategies
direct
chemical
modification,
lipid
insertion,
hybridization,
metabolic
glycan
labeling,
genetic
engineering.
Following
this,
evaluation
unique
attributes
various
presented,
delivering
in-depth
scrutiny
substantial
advancements
applications
driven
cutting-edge
engineered
camouflage.
The
discourse
culminates
recapitulating
salient
influence
within
nanomaterial
prognosticates
its
seminal
role
healthcare
technologies.
It
envisaged
that
insights
offered
herein
will
catalyze
novel
avenues
innovation
refinement
camouflaged
nanotechnologies.
Cell
membrane
coating
has
emerged
as
a
promising
strategy
for
the
surface
modification
of
biomaterials
with
biological
membranes,
serving
cloak
that
can
carry
more
functions.
The
cloaked
inherit
diverse
intrinsic
biofunctions
derived
from
different
cell
sources,
including
enhanced
biocompatibility,
immunity
evasion,
specific
targeting
capacity,
and
immune
regulation
regenerative
microenvironment.
characteristics
biomimicry
biointerfacing
have
demonstrated
versatility
technology
on
variety
biomaterials,
thus,
furthering
research
into
wide
range
biomedical
applications
clinical
translation.
Here,
preparation
coatings
is
emphasized,
sizes
coated
nanoscale
to
macroscale
well
engineering
strategies
introduce
additional
are
summarized.
Subsequently,
utilization
biomimetic
membrane-cloaked
in
discussed,
drug
delivery,
imaging
phototherapy,
cancer
immunotherapy,
anti-infection
detoxification,
implant
modification.
In
conclusion,
latest
advancements
preclinical
studies,
along
multiple
benefits
membrane-coated
nanoparticles
(NPs)
systems,
elucidated.
Active
components
of
natural
products,
which
include
paclitaxel,
curcumin,
gambogic
acid,
resveratrol,
triptolide
and
celastrol,
have
promising
anti-inflammatory,
antitumor,
anti-oxidant,
other
pharmacological
activities.
However,
their
clinical
application
is
limited
due
to
low
solubility,
instability,
bioavailability,
rapid
metabolism,
short
half-life,
strong
off-target
toxicity.
To
overcome
these
drawbacks,
cell
membrane-based
biomimetic
nanosystems
emerged
that
avoid
clearance
by
the
immune
system,
enhance
targeting,
prolong
drug
circulation,
while
also
improving
solubility
enhancing
efficacy,
reducing
side
effects.
This
review
summarizes
recent
advances
in
preparation
coating
membrane-coated
applications
disease
for
targeted
products
delivery.
Current
challenges,
limitations,
prospects
this
field
are
discussed,
providing
a
research
basis
development
multifunctional
products.
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Фев. 8, 2025
Sojae
semen
praeparatum
is
a
traditional
Chinese
medicine,
and
its
active
component,
Glycitin,
has
shown
potential
in
the
treatment
of
non-small
cell
lung
cancer
(NSCLC).
The
purpose
this
investigation
to
examine
mechanism
action
effective
components
sojae
NSCLC,
with
special
emphasis
on
explore
integration
nanotechnology
delivering
pharmaceutical
agents.
Key
were
selected
through
network
pharmacology
analysis
functional
analysis,
protein–protein
interaction
enrichment
performed
using
transcriptomics
metabolomics
data
identify
key
NSCLC-related
target
genes
regulatory
mechanisms
praeparatum.
Glycitin-loaded
NPs
encapsulated
tumor-associated
fibroblast
membranes
developed
verify
their
characterization
safety,
therapeutic
effects
inhibiting
malignant
phenotype
NSCLC
cells
targeting
DNA
topoisomerase
II
alpha
(TOP2A)
protein
validated.
results
indicate
that
Glycitin
exhibits
significant
anti-tumor
activity
by
affecting
function
TOP2A
protein,
thereby
tumor
proliferation
metastasis.
This
research
presents
proof
crucial
managing
praeparatum,
sheds
light
possibilities
drug
delivery
mechanisms,
offering
novel
avenue
for
therapy
research.
Translational Oncology,
Год журнала:
2023,
Номер
40, С. 101846 - 101846
Опубликована: Дек. 1, 2023
The
treatment
of
cancer
patients
has
been
mainly
followed
using
chemotherapy
and
it
is
a
gold
standard
in
improving
prognosis
survival
rate
patients.
Oxaliplatin
(OXA)
third-platinum
anti-cancer
agent
that
reduces
DNA
synthesis
cells
to
interfere
with
their
growth
cell
cycle
progression.
In
spite
promising
results
OXA
chemotherapy,
the
process
drug
resistance
made
some
challenges.
commonly
applied
colorectal
(CRC)
as
malignancy
gastrointestinal
tract
when
CRC
increase
proliferation
metastasis,
they
can
obtain
chemotherapy.
A
number
molecular
factors
such
CHK2,
SIRT1,
c-Myc,
LATS2
FOXC1
have
considered
regulators
response
cells.
non-coding
RNAs
are
able
function
master
regulator
other
pathways
modulating
resistance.
There
close
association
between
mechanisms
apoptosis,
autophagy,
glycolysis
EMT
resistance,
so
apoptosis
inhibition,
pro-survival
autophagy
induction
stimulation
induce
anti-tumor
compounds
including
astragaloside
IV,
resveratrol
nobiletin
enhance
sensitivity
Nanoparticles
for
increasing
potential
suppression
reversing
employed
These
subjects
covered
this
review
article
shed
light
on
resulting
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(4), С. 1483 - 1493
Опубликована: Янв. 2, 2024
Cardiac
resident
macrophages
(CRMs)
are
the
main
population
of
cardiac
immune
cells.
The
role
these
cells
in
regeneration,
functional
remodeling,
and
repair
after
injury
is
always
focus
research.
However,
recent
years,
their
dynamic
changes
contributions
physiological
states
have
a
significant
attention.
CRMs
specific
phenotypes
functions
different
chambers
or
locations
heart
at
stages.
They
further
show
differentiation
development
processes.
present
review
will
summarize
new
progress
about
spatiotemporal
distribution,
potential
developmental
regulation,
roles
aging
as
well
translational
on
diseases.
Of
course,
research
tools
for
CRMs,
respective
advantages
disadvantages,
key
issues
be
discussed.
