Aging and Disease,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Stroke
is
a
leading
cause
of
death
and
disability
in
the
world.
Astrocytes
are
special
glial
cells
within
central
nervous
system
play
important
roles
mediating
neuroprotection
repair
processes
during
stroke.
Extracellular
vesicles
(EVs)
lipid
bilayer
particles
released
from
that
facilitate
intercellular
communication
stroke
by
delivering
proteins,
lipids,
RNA
to
target
cells.
Recently,
accumulating
evidence
suggested
astrocyte-derived
EVs
(ADEVs)
actively
involved
numerous
biological
including
neurorepair
they
realized
as
an
excellent
therapeutic
approach
for
treating
In
this
review
we
systematically
summarize
up-to-date
research
on
ADEVs
stroke,
prospects
its
potential
novel
We
also
provide
overview
effects
functions
recovery,
which
may
lead
developing
clinically
relevant
therapies
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Март 11, 2023
Abstract
The
frequent
outbreak
of
global
infectious
diseases
has
prompted
the
development
rapid
and
effective
diagnostic
tools
for
early
screening
potential
patients
in
point-of-care
testing
scenarios.
With
advances
mobile
computing
power
microfluidic
technology,
smartphone-based
health
platform
drawn
significant
attention
from
researchers
developing
devices
that
integrate
optical
detection
with
artificial
intelligence
analysis.
In
this
article,
we
summarize
recent
progress
these
platforms,
including
aspects
chips,
imaging
modalities,
supporting
components,
software
algorithms.
We
document
application
platforms
terms
objects,
molecules,
viruses,
cells,
parasites.
Finally,
discuss
prospects
future
platforms.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 20, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
natural,
cell-derived
that
contain
the
same
nucleic
acids,
proteins,
and
lipids
as
their
source
cells.
Thus,
they
can
serve
natural
carriers
for
therapeutic
agents
drugs,
have
many
advantages
over
conventional
nanocarriers,
including
low
immunogenicity,
good
biocompatibility,
blood
–
brain
barrier
penetration,
capacity
gene
delivery.
This
review
first
introduces
classification
of
EVs
then
discusses
several
currently
popular
methods
isolating
purifying
EVs,
EVs-mediated
drug
delivery,
functionalization
carriers.
Thereby,
it
provides
new
avenues
development
EVs-based
strategies
in
different
fields
medicine.
Finally,
highlights
some
challenges
future
perspectives
with
regard
to
clinical
application
EVs.
Graphical
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Фев. 8, 2023
Gene
therapy
provides
a
promising
approach
in
treating
cancers
with
high
efficacy
and
selectivity
few
adverse
effects.
Currently,
the
development
of
functional
vectors
safety
effectiveness
is
intense
focus
for
improving
delivery
nucleic
acid
drugs
gene
therapy.
For
this
purpose,
stimuli-responsive
nanocarriers
displayed
strong
potential
overall
efficiencies
reducing
effects
via
effective
protection,
prolonged
blood
circulation,
specific
tumor
accumulation,
controlled
release
profile
drugs.
Besides,
synergistic
could
be
achieved
when
combined
other
therapeutic
regimens.
This
review
summarizes
recent
advances
various
delivery.
Particularly,
responding
to
endogenous
stimuli
including
pH,
reactive
oxygen
species,
glutathione,
enzyme,
etc.,
exogenous
light,
thermo,
ultrasound,
magnetic
field,
are
introduced.
Finally,
future
challenges
prospects
toward
clinical
translation
well
discussed.
The
major
objective
present
biomedical
cancer
provide
guidance
developing
novel
nanoplatforms
that
clinically
applicable.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(8), С. 3327 - 3361
Опубликована: Май 13, 2024
Mitophagy,
essential
for
mitochondrial
health,
selectively
degrades
damaged
mitochondria.
It
is
intricately
linked
to
the
cGAS–STING
pathway,
crucial
innate
immunity.
This
pathway
responds
DNA
and
associated
with
cellular
stress.
Our
review
explores
molecular
details
regulatory
mechanisms
of
mitophagy
pathway.
We
critically
evaluated
literature
demonstrating
how
dysfunctional
leads
neuroinflammatory
conditions,
primarily
through
accumulation
mitochondria,
activating
activation
prompts
production
proinflammatory
cytokines,
exacerbating
neuroinflammation.
emphasizes
interaction
between
Effective
might
suppress
offering
protection
against
Conversely,
impaired
may
activate
potentially
leading
chronic
Additionally,
we
explored
this
influences
neurodegenerative
disorders,
suggesting
a
common
mechanism
in
such
diseases.
In
conclusion,
there
need
additional
targeted
research
unravel
complexities
mitophagy–cGAS–STING
interactions
their
role
neurodegeneration.
highlights
potential
therapies
targeting
these
pathways,
which
could
lead
new
treatments
conditions.
synthesis
enhances
our
understanding
foundations
neuroinflammation
opens
therapeutic
avenues
disease
research.
Bioactive Materials,
Год журнала:
2022,
Номер
25, С. 500 - 526
Опубликована: Авг. 11, 2022
Extracellular
vesicles
(EVs)
are
nano-scale
derived
by
cell
secretion
with
unique
advantages
such
as
promoting
proliferation,
anti-inflammation,
blood
vessels
and
regulating
differentiation,
which
benefit
their
wide
applications
in
regenerative
medicine.
However,
the
Bioactive Materials,
Год журнала:
2024,
Номер
39, С. 521 - 543
Опубликована: Май 30, 2024
Spinal
cord
injury
(SCI)
often
results
in
irreversible
loss
of
sensory
and
motor
functions,
most
SCIs
are
incurable
with
current
medical
practice.
One
the
hardest
challenges
treating
SCI
is
development
a
dysfunctional
pathological
microenvironment,
which
mainly
comprises
excessive
inflammation,
deposition
inhibitory
molecules,
neurotrophic
factor
deprivation,
glial
scar
formation,
imbalance
vascular
function.
To
overcome
this
challenge,
implantation
functional
biomaterials
at
site
has
been
regarded
as
potential
treatment
for
modulating
microenvironment
to
support
axon
regeneration,
remyelination
site,
recovery
after
SCI.
This
review
summarizes
characteristics
recent
advances
well
technologies
used
modulate
inflammatory
regulate
reshape
revascularization
microenvironment.
Moreover,
technological
limitations,
challenges,
future
prospects
promote
efficient
repair
also
discussed.
will
aid
further
understanding
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 20, 2024
Ischemic
stroke
poses
significant
challenges
in
terms
of
mortality
and
disability
rates
globally.
A
key
obstacle
to
the
successful
treatment
ischemic
lies
limited
efficacy
administering
therapeutic
agents.
Leveraging
unique
properties
nanoparticles
for
brain
targeting
crossing
blood-brain
barrier,
researchers
have
engineered
diverse
nanoparticle-based
drug
delivery
systems
improve
outcomes
stroke.
This
review
provides
a
concise
overview
pathophysiological
mechanisms
implicated
stroke,
encompassing
oxidative
stress,
glutamate
excitotoxicity,
neuroinflammation,
cell
death,
elucidate
potential
targets
systems.
Furthermore,
outlines
classification
according
these
distinct
physiological
processes.
categorization
aids
identifying
attributes
commonalities
that
target
specific
pathways
thereby
facilitating
advancement
nanomedicine
development.
The
discusses
benefits
existing
associated
with
employing
offering
new
perspectives
on
designing
efficacious
enhance
outcomes.
RSC Advances,
Год журнала:
2024,
Номер
14(11), С. 7383 - 7413
Опубликована: Янв. 1, 2024
The
fundamentals
of
bio-orthogonal
click
chemistry
are
investigated,
while
exploring
mechanistic
intricacies,
demonstrating
the
adaptability
and
promise
this
methodology.
