Acta Physiologica,
Год журнала:
2024,
Номер
240(3)
Опубликована: Янв. 17, 2024
Abstract
Myocardial
infarction
(MI)
and
its
associated
complications
including
ventricular
arrhythmias
heart
failure
are
responsible
for
a
significant
incidence
of
morbidity
mortality
worldwide.
The
ensuing
cardiomyocyte
loss
results
in
neurohormone‐driven
cardiac
remodeling,
which
leads
to
chronic
MI
survivors.
Ivabradine
is
rate
modulation
agent
currently
used
treatment
with
reduced
ejection
fraction.
canonical
target
ivabradine
the
hyperpolarization‐activated
cyclic
nucleotide‐gated
channels
(HCN)
pacemaker
cells.
However,
post‐MI
hearts,
HCN
can
also
be
expressed
ectopically
non‐pacemaker
cardiomyocytes.
There
an
accumulation
intriguing
evidence
suggest
that
possesses
cardioprotective
effects
independent
reduction.
This
review
aims
summarize
discuss
reported
mechanisms
beyond
myocardial
through
various
molecular
prevention
reactive
oxygen
species‐induced
mitochondrial
damage,
improvement
autophagy
system,
intracellular
calcium
cycling,
modification
electrophysiology,
regulation
matrix
metalloproteinases.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2023,
Номер
1878(6), С. 189024 - 189024
Опубликована: Ноя. 1, 2023
For
decades,
common
chemotherapeutic
drugs
have
been
established
to
trigger
apoptosis,
the
preferred
immunologically
"silent"
form
of
cell
death.
The
primary
objective
this
review
was
show
that
various
FDA-approved
drugs,
including
cisplatin,
cyclosporine,
doxorubicin,
etoposide,
5-fluorouracil,
gemcitabine,
paclitaxel,
or
vinblastine
can
necroptosis
and
pyroptosis.
We
aimed
provide
advantages
disadvantages
induction
given
type
death
by
chemotherapeutical
agents.
Moreover,
we
give
a
short
overview
molecular
mechanism
each
indicate
existing
crosstalks
between
types.
Finally,
comparison
types
facilitate
exploration
induced
other
Understanding
pathway
drug
lessen
side
effects
assist
discovery
new
combinations
with
synergistic
low
systemic
toxicity.
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
12(12), С. 4458 - 4471
Опубликована: Ноя. 4, 2022
Pyroptosis
provides
a
new
window
for
relieving
the
tumor
immunosuppressive
microenvironment
(TIM)
and
promoting
systemic
immune
responses
treatments.
However,
gasdermin
D
(GSDMD),
key
protein
in
pyroptosis
process
mediated
by
caspase-1,
is
low
expressed
majority
of
cells
small-molecule
inhibitors
DNA
methylation
suffer
from
nonspecific
or
single-function
defects.
To
address
these
issues,
hexahistidine
(His
