Current status and trends in small nucleic acid drug development: Leading the future

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(9), С. 3802 - 3817

Опубликована: Май 13, 2024

Small nucleic acid drugs, composed of nucleotides, represent a novel class pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics. These agents function by selectively targeting specific genes or their corresponding messenger RNAs (mRNAs), further modulating gene expression regulating translation-related processes. Prominent examples within this category include antisense oligonucleotides (ASO), interfering (siRNAs), microRNAs (miRNAs), aptamers. The emergence drugs as focal point in contemporary biopharmaceutical research is attributed to remarkable specificity, facile design, abbreviated development cycles, expansive target spectrum, prolonged activity. Overcoming challenges such poor stability, immunogenicity, permeability issues have been addressed through the integration chemical modifications drug delivery systems. This review provides an overview current status prospective trends development. Commencing with historical context, we introduce primary classifications mechanisms drugs. Subsequently, delve into advantages U.S. Food Drug Administration (FDA) approved mainly discuss encountered during Apart researching modification system efficiently deliver enrich tissues, promoting endosomal escape critical scientific question important direction siRNA Future directions field will prioritize addressing these facilitate clinical transformation

Язык: Английский

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Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1

Advanced Science, Год журнала: 2024, Номер 11(16)

Опубликована: Фев. 15, 2024

Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation transient receptor potential vanilloid 1 (TRPV1) significantly alleviated degeneration by abolishing chondrocyte ferroptosis. In this work, in view thermal activated feature TRPV1, Citrate-stabilized gold nanorods (Cit-AuNRs) conjugated to TRPV1 monoclonal antibody (Cit-AuNRs@Anti-TRPV1) as a photothermal switch for chondrocytes under near infrared (NIR) irradiation. The conjugation barely affect morphology and physicochemical properties Cit-AuNRs. Under NIR irradiation, Cit-AuNRs@Anti-TRPV1 exhibited good biocompatibility flexible responsiveness. Intra-articular injection followed irradiation attenuated degradation suppressing osteophyte formation subchondral bone sclerosis are remarkably NIR-inspired Cit-AuNRs@Anti-TRPV1. Furthermore, evidently improved physical activities pain destabilization medial meniscus (DMM)-induced OA mice. study reveals protects from ferroptosis attenuates progression, providing therapeutic strategy treatment OA.

Язык: Английский

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Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

The Chemical Record, Год журнала: 2024, Номер 24(4)

Опубликована: Март 19, 2024

Abstract Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist orthorhombic arrays metal with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced bioavailability, LDHs have many potential applications in medical field. Especially fields bioimaging tumor therapy. This paper reviews research progress nanocomposites field imaging First, structure advantages LDH discussed. Then, several commonly used methods for preparation presented, co‐precipitation, hydrothermal ion exchange methods. Subsequently, recent advances layered cancer therapy highlighted. Finally, based on current research, we summaries prospects challenges diagnosis

Язык: Английский

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One‐Step Synthesis of Hydrogel Adhesive with Acid‐Responsive Tannin Release for Diabetic Oral Mucosa Defects Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(9)

Опубликована: Янв. 21, 2024

Abstract The complex preparation, weak wet tissue adhesion, and limited biological activity of traditional oral wound dressings usually impede their efficient treatment healing for diabetic mucosal defects. To overcome these problems, a novel hydrogel adhesive (named CFT hydrogel) is rapidly constructed using one‐step method based on dual‐dynamic covalent cross‐linking. Compared with the commercial patches, shows superior in vivo (rat tongue) adhesion performance. Additionally, exhibits unique acid‐responsive properties, thereby facilitating release bioactive molecule tannic acid acidic microenvironment. And series vitro experiments substantiate favorable biocompatibility bioactivity properties (including antibacterial, antioxidative, anti‐inflammatory, angiogenetic effects) exhibited by hydrogel. Moreover, conducted rat model defects demonstrate that significant efficacy protecting against wounds, alleviating inflammatory reactions, wound‐healing process. Taken together, this study provides promising comprehensive therapeutic option great potential clinical management mucosa patients.

Язык: Английский

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Inhalable nanomedicine for lung cancer treatment

Smart Materials in Medicine, Год журнала: 2024, Номер 5(2), С. 261 - 280

Опубликована: Апрель 11, 2024

Lung cancer has surpassed other types of to become the primary cause cancer-related deaths. Surgery stands as foremost clinical treatment strategy available for tackling this condition, but it receives a low efficiency most patients. In recent years, some adjuvant therapies are employed improve lung efficiency, such chemotherapy, targeted therapy and immunotherapy. However, these strategies have not significantly increased overall survival Additionally, random distribution drugs will induce severe side effects. Nanomedicines got great attentions boost drug effect reduce adverse reactions, including liposome-based nanoparticles, polymeric inorganic exosomes. Importantly, nanomedicines contribute improving bioavailability, stability residency in target regions. Benefiting from physiological characteristics lung, inhaled pulmonary delivery combination with nanomedicine provide non-invasive effective treating cancer. Furthermore, use targeting ligands enables precise loaded cells. Inhaled exhibits unique sustained release behaviors alveoli, amplifying therapeutic reducing This review aims discuss various methods delivering treat also summarizes clearance mechanism lung. Overall, focuses on application different inhalable nanomedicines, which may inspire development more treatments against

Язык: Английский

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Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Random flap grafting is a routine procedure used in plastic and reconstructive surgery to repair reconstruct large tissue defects. Flap necrosis primarily caused by ischemia–reperfusion injury inadequate blood supply the distal flap. Ischemia–reperfusion leads production of excessive reactive oxygen species, creating pathological microenvironment that impairs cellular function angiogenesis. In this study, we developed remodeling self-healing hydrogel [laminarin–chitosan-based hydrogel-loaded extracellular vesicles ceria nanozymes (LCH@EVs&CNZs)] improve synergistically promote regeneration survival. The natural (LCH) was created oxidation laminarin carboxymethylated chitosan via Schiff base reaction. We loaded with CNZs EVs. are class nanomaterials enzymatic activity known for their strong scavenging capacity thus alleviating oxidative stress. EVs cell-secreted vesicular structures containing thousands bioactive substances can cell proliferation, migration, differentiation, constructed LCH@EVs&CNZs demonstrated robust excess thereby conferring protection stress environments. Moreover, these constructs notably enhance migration Our results demonstrate effectively remodel skin marked This approach introduces new therapeutic strategy combining microenvironmental EV therapy, which holds promise promoting

Язык: Английский

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Multifunctional MXenes nanocomposite platforms for biosensing and wearable sensor technologies

Advanced Composites and Hybrid Materials, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 20, 2024

Язык: Английский

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PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 22, 2025

Язык: Английский

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Machine learning-driven optimization of mRNA-lipid nanoparticle vaccine quality with XGBoost/Bayesian method and ensemble model approaches

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(11), С. 100996 - 100996

Опубликована: Май 8, 2024

To enhance the efficiency of vaccine manufacturing, this study focuses on optimizing microfluidic conditions and lipid mix ratios messenger RNA-lipid nanoparticles (mRNA-LNP). Different mRNA-LNP formulations (

Язык: Английский

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Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood–spinal cord barrier and neurons

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(18), С. 4409 - 4426

Опубликована: Янв. 1, 2024

The tetramethylpyrazine-loaded conductive hydrogel could diminish the breakdown of blood–spinal cord barrier and protect against neuronal cell death to synergistically restore neurological functions post spinal injury.

Язык: Английский

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