Targeting MAPK-ERK/JNK pathway: A potential intervention mechanism of myocardial fibrosis in heart failure

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116413 - 116413

Опубликована: Март 9, 2024

Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation the ERK1/2 and JNK1/2 signaling pathways MAPK family members synergistically promotes proliferation myocardial fibroblasts accelerates development fibrosis. In addition to some small molecule inhibitors Western drugs, many Chinese medicines can also inhibit activity JNK1/2, thus slowing down fibrosis, are generally safe effective. However, specific biological mechanisms in still need be fully understood, there no systematic review existing drugs methods them from improving This study aims summarize roles cross-linking systematically sort out small-molecule inhibitors, traditional medicines, non-pharmacological therapies that alleviate future, we hope conduct more in-depth research perspective precision-targeted therapy, using this as for developing new provide perspectives on prevention treatment

Язык: Английский

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Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management

Phytomedicine, Год журнала: 2024, Номер 128, С. 155472 - 155472

Опубликована: Фев. 24, 2024

Язык: Английский

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Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 23, 2024

Traditional Chinese medicine (TCM) is the practical experience and summary of nation for thousands years. It shows great potential in treating various chronic diseases, complex diseases major infectious has gradually attracted attention people all over world. However, due to complexity prescription action mechanism TCM, development TCM industry still a relatively conservative stage. With rise artificial intelligence technology fields, many scholars began apply traditional made remarkable progress. This paper comprehensively summarizes important role from aspects, including new drug discovery, data mining, quality standardization medicine. The limitations these applications are also emphasized, lack pharmacological research, database problems challenges brought by human-computer interaction. Nevertheless, opportunities innovations modernization Integrating into comprehensive application expected overcome faced further promote whole industry.

Язык: Английский

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Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway

Journal of Ethnopharmacology, Год журнала: 2024, Номер 330, С. 118264 - 118264

Опубликована: Апрель 29, 2024

Язык: Английский

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Acute and sub-acute toxicity study of aqueous and methanol root extract of Tetracera alnifolia in male albino rats.

Toxicology Reports, Год журнала: 2024, Номер 13, С. 101786 - 101786

Опубликована: Окт. 22, 2024

The aim of this study was to assess the acute and sub-acute toxicity aqueous methanol extracts root

Язык: Английский

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Intestinal mucosal barrier: a potential target for traditional Chinese medicine in the treatment of cardiovascular diseases

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 26, 2024

Graphical Abstract This review presents the progress of traditional Chinese medicines in treating CVD by repairing intestinal mucosal barrier

Язык: Английский

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Strategies for the Construction of Benzobicyclo[3.2.1]octane in Natural Product Synthesis

Chemistry - A European Journal, Год журнала: 2024, Номер 30(25)

Опубликована: Фев. 12, 2024

Abstract Benzobicyclo[3.2.1]octane is a cage‐like unique motif containing bicyclo[3.2.1]octane structure fused with at least one benzene ring. It found in various natural products that exhibit structural complexities and important biological activities. The total synthesis of possessing this challenging has received considerable attention, great advances have been made field during the past 15 years. This review summarizes thus far achieved chemical syntheses synthetic studies compounds featuring benzobicyclo[3.2.1]octane core. focuses on strategic approaches constructing bridged structure, aiming to provide useful reference for inspiring further advancements strategies such framework.

Язык: Английский

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Traditional Chinese medicine as a protective strategy against chemotherapy-induced cardiotoxicity: An overview of the literature

Journal of Traditional and Complementary Medicine, Год журнала: 2024, Номер 15(2), С. 107 - 118

Опубликована: Июнь 22, 2024

Cardiotoxicity refers to the damage caused heart or vascular system, which has become a significant cause of morbidity and mortality worldwide. Up 20 % adults undergoing cancer treatment may experience cardiotoxicity, with 7 %-10 developing cardiomyopathy failure. Cardiotoxic medications put patients at risk for variety conditions, including cardiac failure (HF), left ventricle (LV) systolic malfunction, arrhythmia, hypertension, coronary artery disease (CAD), ischemia/myocardial infarction. These diseases significantly impact patient's quality life outcomes. Many conventional chemotherapy agents have serious adverse effects. Anthracyclines, alkylating agents, taxanes, topoisomerase inhibitors, antimetabolites are chemotherapeutic that induce cardiotoxicity. Recently, there been an increasing focus on using traditional Chinese medicine (TCM) treat chemotherapy-induced TCM encompasses range practices, such as herbology, acupuncture, dietary therapy, physical exercises like t'ai chi. practices aim enhance flow qi, can alleviate symptoms illness. Although effectiveness not extensively researched supported, scientists begun utilizing scientific methods gain deeper understanding mechanisms underlying TCM. Ongoing research is being conducted determine safety treatments in reducing toxicity. The present study aims evaluate protection efficacy various

Язык: Английский

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Review on the Treatment of Cerebral Ischemia-Reperfusion Injury by Traditional Chinese Medicine

Journal of Clinical and Nursing Research, Год журнала: 2025, Номер 8(12), С. 295 - 303

Опубликована: Янв. 6, 2025

This study aims to investigate the clinical effects and mechanisms of traditional Chinese medicine (TCM) in treating cerebral ischemia-reperfusion injury. Through a systematic review analysis relevant literature, evaluates TCM on nerve function recovery, regulation oxidative stress responses, its combination with Western medicine. Findings reveal that medicinal formulations, such as Danshen decoction Naoxintong, significantly improve NIHSS scores, reduce ischemic lesion areas, lower marker levels patients. These formulations exhibit unique advantages modulating inflammatory their integration enhances therapeutic efficacy while reducing adverse reactions. The effectiveness prescriptions offers novel approach for managing injury promotes advancement integrated Chinese-Western treatment strategies. Further research is required elucidate precise facilitate broader application.

Язык: Английский

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Shuxuening injection improves myocardial injury after myocardial infarction by regulating macrophage polarization via the TLR4/NF-κB and PI3K/Akt signaling pathways

Phytomedicine, Год журнала: 2025, Номер 138, С. 156418 - 156418

Опубликована: Янв. 23, 2025

Язык: Английский

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