Microchemical Journal, Год журнала: 2024, Номер unknown, С. 112296 - 112296
Опубликована: Ноя. 1, 2024
Язык: Английский
The Science of The Total Environment, Год журнала: 2024, Номер 929, С. 172734 - 172734
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
26
Micro, Год журнала: 2023, Номер 3(4), С. 822 - 866
Опубликована: Окт. 31, 2023
In recent years, the field of drug delivery has seen a significant shift towards exploration and utilization nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs’ characteristics, microfluidics emerged potent platform efficient controlled synthesis NPs. Microfluidic devices designed precise fluid manipulation at micro-scale offer unique tailoring NP properties, enabling enhanced properties such size, morphology, size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used produce liposomes, solid lipid nanoparticles, polymer-based NPs, lipid-polymer hybrid well variety inorganic NPs silica, metal, metal oxide, quantum dots, carbon-based offering composition surface properties. Its precision in holds great promise advancing NP-based systems both clinical industrial settings. Although challenges with large-scale production still remain, offers transformative approach synthesis. this review, starting from historical development microfluidic systems, materials create microfabrication methods, system components will discussed order reader an overview systems. following, studies on fabrication polymeric are included.
Язык: Английский
Процитировано
30
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Ноя. 14, 2024
Abstract In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications. This surge can be largely attributed to demonstration of distinct advantages offered by various mRNA molecules, alongside rapid advancements nucleic delivery systems. It is noteworthy that immunogenicity presents a double-edged sword. context immunotherapy, extra supplementation adjuvant generally required for induction robust immune responses. Conversely, non-immunotherapeutic scenarios, activation unwanted considering host tolerability high expression demand mRNA-encoded functional proteins. Herein, mainly focused on linear non-replicating mRNA, we overview preclinical clinical progress prospects medicines encompassing vaccines other therapeutics. We also highlight importance focusing host-specific variations, including age, gender, pathological condition, concurrent medication individual patient, maximized efficacy safety upon administration. Furthermore, deliberate potential challenges may encounter realm disease treatment, current endeavors improvement, as well application future advancements. Overall, this review aims present comprehensive understanding mRNA-based therapies while illuminating prospective development drugs.
Язык: Английский
Процитировано
17
Biomarker Research, Год журнала: 2024, Номер 12(1)
Опубликована: Дек. 5, 2024
Abstract Early detection of cancer significantly improves patient outcomes, with biomarkers offering a promising avenue for earlier and more precise diagnoses. Microfluidic biosensors have emerged as powerful tool detecting these in body fluids, providing enhanced sensitivity, specificity, rapid analysis. This review focuses on recent advances microfluidic from 2018 to 2024, detailing their operational principles, fabrication techniques, integration nanotechnology biomarker detection. Additionally, we reviewed innovations several aspects biosensors, such novel technologies, nanomaterials chip structures, which enhance capabilities. We highlight key pertinent early explore how biosensor technology contribute the evolving landscape personalized medicine. further technologies could be incorporated into clinical diagnostic workflows improve treatment outcomes. These help enable diagnostics. In addition, this addresses important issues enhancing scalability sensitivity settings points out future possibilities combining artificial intelligence diagnostics optimize practical applications. overview aims guide research applications by addressing current challenges identifying opportunities development field research.
Язык: Английский
Процитировано
16
Deleted Journal, Год журнала: 2024, Номер 2(2)
Опубликована: Май 1, 2024
Abstract Considering the continuous advances in synthesis and clinical applications of monoclonal antibodies (mAbs), precision therapies that employ mAbs are essential. In recent years, extensive efforts have been invested developing novel strategies or technologies for detection mAbs. Given availability advanced biosensing materials, various assemblies multifunctional materials can be prepared by intelligent design when evaluating targets This article provides an overview functional mAb detection. Subsequently, we present approaches which receptors combined with to construct stimulus‐responsive analytical platforms evaluate contents activities biological systems, enabling real‐time monitoring diagnosis could facilitate administration during treatment. Furthermore, review examines implications real‐world contexts; it also discusses ongoing challenges future prospects.
Язык: Английский
Процитировано
9
Computers and Electronics in Agriculture, Год журнала: 2025, Номер 229, С. 109941 - 109941
Опубликована: Янв. 20, 2025
Процитировано
1
Discover Chemistry., Год журнала: 2025, Номер 2(1)
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 666 - 666
Опубликована: Май 16, 2024
Organ-on-a-chip technology is attracting growing interest across various domains as a crucial platform for drug screening and testing set to play significant role in precision medicine research. Lymph nodes, being intricately structured organs essential the body’s adaptive immune responses antigens foreign particles, are pivotal assessing immunotoxicity of novel pharmaceuticals. Significant progress has been made research on structure function lymphatic system. However, there still an urgent need develop prospective tools techniques delve deeper into its diseases’ pathological physiological processes corresponding immunotherapeutic therapies. Organ chips can accurately reproduce specific functional areas lymph nodes better simulate complex microstructure interactions between different cells, which convenient studying biological processes. This paper reviews existing node their design approaches. It discusses applications above systems modeling cell motility, cell–cell interactions, vaccine responses, testing, cancer Finally, we summarize challenges that current faces terms structure, source, extracellular matrix simulation provide outlook future direction integrated system chips.
Язык: Английский
Процитировано
6
Talanta, Год журнала: 2023, Номер 266, С. 124961 - 124961
Опубликована: Июль 18, 2023
Язык: Английский
Процитировано
13
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 23, 2024
Abstract Biological evaluation of biomedical materials faces constraints imposed by the limitations traditional in vitro and animal experiments. Currently, miniaturized biomimetic microfluidic technologies organ‐on‐chip systems have garnered widespread attention field drug development. However, their exploration context material medical device development remains relatively limited. In this review, a summary existing biological methods, highlighting respective advantages drawbacks is provided. The application materials, emphasizing potential as highly models then focused. Finally, challenges opportunities associated with utilizing to evaluate are discussed. conclusion, integration advanced presents paradigm shift assessment offering prospective more accurate predictive devices.
Язык: Английский
Процитировано
5